A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests

On rare variants in principal component analysis of population stratification

(2020) Shengqing Ma et al.   BMC GENETICS

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

(2020) Xihao Li et al.   NATURE GENETICS

A comparison of popular TDT-generalizations for family-based association analysis

(2019) Julian Hecker et al.   GENETIC EPIDEMIOLOGY

ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies

(2019) Yaowu Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies

(2019) Zilin Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A genome-wide scan statistic framework for whole-genome sequence data analysis

(2019) Zihuai He et al.   Nature Communications

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

(2018) Wei Zhou et al.   NATURE GENETICS

Family-based tests for associating haplotypes with general phenotype data

(2017) Julian Hecker et al.   GENETIC EPIDEMIOLOGY

On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows

(2017) Heide Loehlein Fier et al.   GENETIC EPIDEMIOLOGY

The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies

(2017) Ian Barnett et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models

(2016) Han Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hypothesis testing for high-dimensional sparse binary regression

(2015) Rajarshi Mukherjee et al.   ANNALS OF STATISTICS

A haplotype-based framework for group-wise transmission/disequilibrium tests for rare variant association analysis

(2015) Rui Chen et al.   BIOINFORMATICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Accurate liability estimation improves power in ascertained case-control studies

(2015) Omer Weissbrod et al.   NATURE METHODS

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

VEGAS2: Software for More Flexible Gene-Based Testing

(2014) Aniket Mishra et al.   Twin Research and Human Genetics

Rare-Variant Extensions of the Transmission Disequilibrium Test: Application to Autism Exome Sequence Data

(2013) Zongxiao He et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Family-based association tests for sequence data, and comparisons with population-based association tests

(2013) Iuliana Ionita-Laza et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Rare Variant Analysis for Family-Based Design

(2013) Gourab De et al.   PLoS One

Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies

(2012) Seunggeun Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Optimal tests for rare variant effects in sequencing association studies

(2012) S. Lee et al.   BIOSTATISTICS

Differential confounding of rare and common variants in spatially structured populations

(2012) Iain Mathieson et al.   NATURE GENETICS

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FaST linear mixed models for genome-wide association studies

(2011) Christoph Lippert et al.   NATURE METHODS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variance component model to account for sample structure in genome-wide association studies

(2010) Hyun Min Kang et al.   NATURE GENETICS

A Generalized Family-Based Association Test for Dichotomous Traits

(2009) Wei-Min Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies

(2009) Sungho Won et al.   PLoS Genetics

Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data

(2008) Bingshan Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sex-stratified Linkage Analysis Identifies a Female-specific Locus for IgE to Cockroach in Costa Ricans

(2008) Gary M. Hunninghake et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

New Powerful Approaches for Family-based Association Tests with Longitudinal Measurements

(2008) Xiao Ding et al.   ANNALS OF HUMAN GENETICS