Iron-sulfur cluster biogenesis, trafficking, and signaling: Roles for CGFS glutaredoxins and BolA proteins

Mechanisms of Mitochondrial Iron-Sulfur Protein Biogenesis

(2020) Roland Lill et al.   Annual Review of Biochemistry

Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis

(2020) Nunziata Maio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Iron–sulfur cluster signaling: The common thread in fungal iron regulation

(2020) Malini Gupta et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

GLRX3 acts as a [2Fe-2S] cluster chaperone in the cytosolic iron-sulfur assembly machinery transferring [2Fe-2S] clusters to NUBP1

(2020) Francesca Camponeschi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A reference map of the human binary protein interactome

(2020) Katja Luck et al.   NATURE

Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins

(2020) Linda Liedgens et al.   Nature Communications

Exploring the Effects of bolA in Biofilm Formation and Current Generation by Shewanella oneidensis MR-1

(2020) Ana V. Silva et al.   Frontiers in Microbiology

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain

(2020) Reza Pourhaghighi et al.   Cell Systems

Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

(2020) Daniel Trnka et al.   Nature Communications

Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes

(2020) Selma S. Alkafeef et al.   PLoS Genetics

Adaptation to iron deficiency in human pathogenic fungi

(2020) María Teresa Martínez-Pastor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

GLRX5 mutations impair heme biosynthetic enzymes ALA synthase 2 and ferrochelatase in Human congenital sideroblastic anemia

(2019) Raêd Daher et al.   MOLECULAR GENETICS AND METABOLISM

The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways

(2019) Tracey A. Rouault   BIOMETALS

A Vibrio cholerae BolA-Like Protein Is Required for Proper Cell Shape and Cell Envelope Integrity

(2019) Aurore Fleurie et al.   mBio

The conserved CDC motif in the yeast iron regulator Aft2 mediates iron–sulfur cluster exchange and protein–protein interactions with Grx3 and Bol2

(2019) Haoran Li et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A PCBP1–BolA2 chaperone complex delivers iron for cytosolic [2Fe–2S] cluster assembly

(2019) Sarju J. Patel et al.   Nature Chemical Biology

The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus

(2019) Matthias Misslinger et al.   PLoS Genetics

Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants?

(2019) Pascal Rey et al.   Frontiers in Plant Science

The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals

(2019) Giuliana Giannuzzi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NMR-Metabolomics Shows That BolA Is an Important Modulator of Salmonella Typhimurium Metabolic Processes under Virulence Conditions

(2019) Graça-Lopes et al.   Metabolites

A pathway for assembling [4Fe‐4S] 2+ clusters in mitochondrial iron–sulfur protein biogenesis

(2019) Veronica Nasta et al.   FEBS Journal

Conserved functions of Arabidopsis mitochondrial late-acting maturation factors in the trafficking of iron‑sulfur clusters

(2018) Marta A. Uzarska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An infant case of diffuse cerebrospinal lesions and cardiomyopathy caused by a BOLA3 mutation

(2018) Makoto Nishioka et al.   BRAIN & DEVELOPMENT

Roles and maturation of iron–sulfur proteins in plastids

(2018) Jonathan Przybyla-Toscano et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3

(2018) Chang-Biao Chi et al.   JOURNAL OF MOLECULAR BIOLOGY

Iba57p participates in maturation of a [2Fe–2S]-cluster Rieske protein and in formation of supercomplexes III/IV of Saccharomyces cerevisiae electron transport chain

(2018) Luis A. Sánchez et al.   MITOCHONDRION

Stress Response Protein BolA Influences Fitness and Promotes Salmonella enterica Serovar Typhimurium Virulence

(2018) Dalila Mil-Homens et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cluster exchange reactivity of [2Fe–2S] cluster-bridged complexes of BOLA3 with monothiol glutaredoxins

(2018) Sambuddha Sen et al.   Metallomics

Iron-Sulfur Cluster Carrier Proteins Involved in the Assembly of Escherichia coli NADH:ubiquinone oxidoreductase (complex I)

(2018) Sabrina Burschel et al.   MOLECULAR MICROBIOLOGY

Imaging phenotype of multiple mitochondrial dysfunction syndrome 2, a rare BOLA3-associated leukodystrophy

(2018) Rahul M. Nikam et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol–Disulfide Exchange between Protein Thiols and Glutathione

(2018) Zhiguang Xiao et al.   JOURNAL OF MOLECULAR BIOLOGY

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans

(2018) Rodgoun Attarian et al.   mBio

Function of glutaredoxin 3 (Grx3) in oxidative stress response caused by iron homeostasis disorder in Candida albicans

(2017) Dan Zhang et al.   Future Microbiology

Loss of Ssq1 leads to mitochondrial dysfunction, activation of autophagy and cell cycle arrest due to iron overload triggered by mitochondrial iron–sulfur cluster assembly defects in Candida albicans

(2017) Yijie Dong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Iron–sulfur cluster biogenesis and trafficking in mitochondria

(2017) Joseph J. Braymer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron–sulfur clusters biogenesis by the SUF machinery: close to the molecular mechanism understanding

(2017) J. Pérard et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe–2S] cluster binding

(2017) Adrienne C. Dlouhy et al.   Metallomics

Impact of mutations within the [Fe-S] cluster or the lipoic acid biosynthesis pathways on mitochondrial protein expression profiles in fibroblasts from patients

(2017) E. Lebigot et al.   MOLECULAR GENETICS AND METABOLISM

Involvement of Arabidopsis glutaredoxin S14 in the maintenance of chlorophyll content

(2017) Pascal Rey et al.   PLANT CELL AND ENVIRONMENT

Mechanisms of iron sensing and regulation in the yeast Saccharomyces cerevisiae

(2017) María Teresa Martínez-Pastor et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation

(2017) Ricardo N. Moreira et al.   mBio

Real-Time Kinetic Probes Support Monothiol Glutaredoxins As Intermediate Carriers in Fe–S Cluster Biosynthetic Pathways

(2016) James N. Vranish et al.   ACS Chemical Biology

The iron uptake repressor Fep1 in the fission yeast binds Fe-S cluster through conserved cysteines

(2016) Hyo-Jin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Escherichia coli BolA Protein IbaG Forms a Histidine-Ligated [2Fe-2S]-Bridged Complex with Grx4

(2016) Adrienne C. Dlouhy et al.   BIOCHEMISTRY

A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery

(2016) Avery G. Frey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function

(2016) Brendan J. Floyd et al.   MOLECULAR CELL

Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility

(2016) Xander Nuttle et al.   NATURE

A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies

(2016) Masakazu Kohda et al.   PLoS Genetics

Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

(2016) Marta A Uzarska et al.   eLife

Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients

(2016) Andrew Melber et al.   eLife

Recent advances in the Suf Fe–S cluster biogenesis pathway: Beyond the Proteobacteria

(2015) F. Wayne Outten   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The roles of glutaredoxins ligating Fe–S clusters: Sensing, transfer or repair functions?

(2015) Jérémy Couturier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular basis of the regulation of iron homeostasis in fission and filamentous yeasts

(2015) Ariane Brault et al.   IUBMB LIFE

Functional Analysis ofGLRX5Mutants Reveals Distinct Functionalities of GLRX5 Protein

(2015) Gang Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway

(2015) Lucia Banci et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Panorama of ancient metazoan macromolecular complexes

(2015) Cuihong Wan et al.   NATURE

N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin

(2015) Lucia Banci et al.   Nature Chemical Biology

The mitochondrial monothiol glutaredoxin S15 is essential for iron-sulfur protein maturation inArabidopsis thaliana

(2015) Anna Moseler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BolA Is a Transcriptional Switch That Turns Off Motility and Turns On Biofilm Development

(2015) Clémentine Dressaire et al.   mBio

A Cascade of Iron-Containing Proteins Governs the Genetic Iron Starvation Response to Promote Iron Uptake and Inhibit Iron Storage in Fission Yeast

(2015) Javier Encinar del Dedo et al.   PLoS Genetics

Regulation of BolA abundance mediates morphogenesis in Fremyella diplosiphon

(2015) Shailendra P. Singh et al.   Frontiers in Microbiology

Heterozygous missense mutations in the GLRX5 gene cause sideroblastic anemia in a Chinese patient

(2014) G. Liu et al.   BLOOD

The role of mitochondria in cytosolic-nuclear iron–sulfur protein biogenesis and in cellular iron regulation

(2014) Roland Lill et al.   CURRENT OPINION IN MICROBIOLOGY

Structural and Spectroscopic Insights into BolA-Glutaredoxin Complexes

(2014) Thomas Roret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of [4Fe-4S] Clusters in the Mitochondrial Iron–Sulfur Cluster Assembly Machinery

(2014) Diego Brancaccio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MorphogenesbolAandmreBmediate the photoregulation of cellular morphology during complementary chromatic acclimation inFremyella diplosiphon

(2014) Shailendra P. Singh et al.   MOLECULAR MICROBIOLOGY

Fra2 Is a Co-Regulator of Fep1 Inhibition in Response to Iron Starvation

(2014) Jean-François Jacques et al.   PLoS One

Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2

(2014) C. B. Poor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking through the stress barrier: the role of BolA in Gram-negative survival

(2014) Inês Batista Guinote et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Arabidopsis thaliana Nfu2 Accommodates [2Fe-2S] or [4Fe-4S] Clusters and Is Competent for in Vitro Maturation of Chloroplast [2Fe-2S] and [4Fe-4S] Cluster-Containing Proteins

(2013) Huanyao Gao et al.   BIOCHEMISTRY

Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5

(2013) Peter R. Baker et al.   BRAIN

Monothiol Glutaredoxins Can Bind Linear [Fe3S4]+ and [Fe4S4]2+ Clusters in Addition to [Fe2S2]2+ Clusters: Spectroscopic Characterization and Functional Implications

(2013) Bo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation

(2013) Petra Haunhorst et al.   MOLECULAR BIOLOGY OF THE CELL

The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation

(2013) Marta A. Uzarska et al.   MOLECULAR BIOLOGY OF THE CELL

Monothiol Glutaredoxin–BolA Interactions: Redox Control of Arabidopsis thaliana BolA2 and SufE1

(2013) Jérémy Couturier et al.   Molecular Plant

Structural insights into the N-terminal GIY–YIG endonuclease activity ofArabidopsisglutaredoxin AtGRXS16 in chloroplasts

(2013) Xi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BOLA1 Is an Aerobic Protein That Prevents Mitochondrial Morphology Changes Induced by Glutathione Depletion

(2012) Peter Willems et al.   ANTIOXIDANTS & REDOX SIGNALING

Mono- and Dithiol Glutaredoxins in the Trypanothione-Based Redox Metabolism of Pathogenic Trypanosomes

(2012) Marcelo A. Comini et al.   ANTIOXIDANTS & REDOX SIGNALING

Monothiol CGFS Glutaredoxins and BolA-like Proteins: [2Fe-2S] Binding Partners in Iron Homeostasis

(2012) Haoran Li et al.   BIOCHEMISTRY

Human Glutaredoxin 3 Forms [2Fe-2S]-Bridged Complexes with Human BolA2

(2012) Haoran Li et al.   BIOCHEMISTRY

Monothiol glutaredoxins and A-type proteins: partners in Fe–S cluster trafficking

(2012) Daphne T. Mapolelo et al.   DALTON TRANSACTIONS

The Monothiol Glutaredoxin Grx4 Exerts an Iron-Dependent Inhibitory Effect on Php4 Function

(2012) Philippe Vachon et al.   EUKARYOTIC CELL

A Role for Iron-Sulfur Clusters in the Regulation of Transcription Factor Yap5-dependent High Iron Transcriptional Responses in Yeast

(2012) Liangtao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homozygous missense mutation in BOLA3 causes multiple mitochondrial dysfunctions syndrome in two siblings

(2012) Tobias B. Haack et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Characterization of the BolA Homolog IbaG: A New Gene Involved in Acid Resistance

(2012) Ines Batista Guinote   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Monothiol Glutaredoxins Function in Storing and Transporting [Fe2S2] Clusters Assembled on IscU Scaffold Proteins

(2012) Priyanka Shakamuri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes

(2011) Jessie M. Cameron et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TheE. coliMonothiol Glutaredoxin GrxD Forms Homodimeric and Heterodimeric FeS Cluster Containing Complexes

(2011) N. Yeung et al.   BIOCHEMISTRY

Grx4 Monothiol Glutaredoxin Is Required for Iron Limitation-Dependent Inhibition of Fep1

(2011) Mehdi Jbel et al.   EUKARYOTIC CELL

Unusual Spinal Cord Lesions in Late-Onset Non-ketotic Hyperglycinemia

(2011) Shu-Hao Wei et al.   JOURNAL OF CHILD NEUROLOGY

Evidence for Network Evolution in an Arabidopsis Interactome Map

(2011) et al.   SCIENCE

Histidine 103 in Fra2 Is an Iron-Sulfur Cluster Ligand in the [2Fe-2S] Fra2-Grx3 Complex and Is Required forin VivoIron Signaling in Yeast

(2010) Haoran Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

(2010) Hong Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

The Yeast Iron Regulatory Proteins Grx3/4 and Fra2 Form Heterodimeric Complexes Containing a [2Fe-2S] Cluster with Cysteinyl and Histidyl Ligation

(2009) Haoran Li et al.   BIOCHEMISTRY

Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery

(2009) D. R. Crooks et al.   BLOOD

Evolution and diversity of glutaredoxins in photosynthetic organisms

(2009) Jérémy Couturier et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metalloproteins and metal sensing

(2009) Kevin J. Waldron et al.   NATURE

Glutaredoxins: roles in iron homeostasis

(2009) Nicolas Rouhier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe–2S] clusters

(2008) Sibali Bandyopadhyay et al.   EMBO JOURNAL

Identification ofFRA1andFRA2as Genes Involved in Regulating the Yeast Iron Regulon in Response to Decreased Mitochondrial Iron-Sulfur Cluster Synthesis

(2008) Attila Kumánovics et al.   JOURNAL OF BIOLOGICAL CHEMISTRY