The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways

Conserved functions of Arabidopsis mitochondrial late-acting maturation factors in the trafficking of iron‑sulfur clusters

(2018) Marta A. Uzarska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cytosolic HSC20 integrates de novo iron–sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients

(2018) Ki Soon Kim et al.   HUMAN MOLECULAR GENETICS

The ErpA/NfuA complex builds an oxidation-resistant Fe-S cluster delivery pathway

(2018) Béatrice Py et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia

(2018) Manik C. Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly

(2018) Jonathan G. Van Vranken et al.   MOLECULAR CELL

The A-type domain in Escherichia coli NfuA is required for regenerating the auxiliary [4Fe–4S] cluster in Escherichia coli lipoyl synthase

(2018) Erin L. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipoic acid metabolism and mitochondrial redox regulation

(2017) Ashley Solmonson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of human Fe–S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP–ISD11 interactions

(2017) Seth A. Cory et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Destruction and reformation of an iron-sulfur cluster during catalysis by lipoyl synthase

(2017) Erin L. McCarthy et al.   SCIENCE

Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex

(2017) Michal T. Boniecki et al.   Nature Communications

The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins

(2017) Diana C. Odermatt et al.   Cell Reports

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB

(2016) Nunziata Maio et al.   Cell Metabolism

Mammalian Fe–S proteins: definition of a consensus motif recognized by the co-chaperone HSC20

(2016) N. Maio et al.   Metallomics

Iron-sulfur proteins hiding in plain sight

(2015) Tracey A Rouault   Nature Chemical Biology

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

(2015) Manik C. Ghosh et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial iron–sulfur protein biogenesis and human disease

(2014) Oliver Stehling et al.   BIOCHIMIE

Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery

(2014) Nunziata Maio et al.   Cell Metabolism

Mammalian iron–sulphur proteins: novel insights into biogenesis and function

(2014) Tracey A. Rouault   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments

(2014) Kimberly B. Zumbrennen-Bullough et al.   PLoS One

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

The L-Cysteine Desulfurase NFS1 Is Localized in the Cytosol where it Provides the Sulfur for Molybdenum Cofactor Biosynthesis in Humans

(2013) Zvonimir Marelja et al.   PLoS One

The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

(2012) Roland Lill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

(2012) T. A. Rouault   Disease Models & Mechanisms

MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity

(2012) O. Stehling et al.   SCIENCE

MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism

(2012) K. Gari et al.   SCIENCE

Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes

(2011) Jessie M. Cameron et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins

(2011) Aleix Navarro-Sastre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human Carbonyl Reductases

(2011) Petra Malatkova et al.   CURRENT DRUG METABOLISM

Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice

(2011) Suh Young Jeong et al.   PLoS One

Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

(2010) Hong Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biophysical Characterization of the Iron in Mitochondria from Atm1p-DepletedSaccharomyces cerevisiae

(2009) Ren Miao et al.   BIOCHEMISTRY

Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis

(2009) Y. Shi et al.   HUMAN MOLECULAR GENETICS

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

Structure of Human J-type Co-chaperone HscB Reveals a Tetracysteine Metal-binding Domain

(2008) Eduard Bitto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Role for Human Nfs1 in the Cytoplasm

(2008) Zvonimir Marelja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular and Mitochondrial Remodeling upon Defects in Iron-Sulfur Protein Biogenesis

(2008) Anja Hausmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron–sulfur cluster biogenesis and human disease

(2008) Tracey A. Rouault et al.   TRENDS IN GENETICS