Single cell metabolomics using mass spectrometry: Techniques and data analysis

Mannose Promotes Metabolic Discrimination of Osteosarcoma Cells at Single-Cell Level by Mass Spectrometry

(2020) Zhuyin Fang et al.   ANALYTICAL CHEMISTRY

Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration

(2020) Stéphanie Blockhuys et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomic and Lipidomic Signatures of Metabolic Syndrome and its Physiological Components in Adults: A Systematic Review

(2020) Stéphanie Monnerie et al.   Scientific Reports

Single-cell morphology encodes metastatic potential

(2020) Pei-Hsun Wu et al.   Science Advances

In Vivo Chemical Analysis of Plant Sap from the Xylem and Single Parenchymal Cells by Capillary Microsampling Electrospray Ionization Mass Spectrometry

(2020) Laith Z. Samarah et al.   ANALYTICAL CHEMISTRY

Single-Cell On-Probe Derivatization–Noncontact Nanocarbon Fiber Ionization: Unraveling Cellular Heterogeneity of Fatty Alcohol and Sterol Metabolites

(2020) Yu-Qi Cao et al.   ANALYTICAL CHEMISTRY

Combining Mass Spectrometry with Paternò–Büchi Reaction to Determine Double-Bond Positions in Lipids at the Single-Cell Level

(2020) Yanlin Zhu et al.   ANALYTICAL CHEMISTRY

Single-Cell Classification Using Mass Spectrometry through Interpretable Machine Learning

(2020) Yuxuan Richard Xie et al.   ANALYTICAL CHEMISTRY

Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations

(2020) Patricia J. Ahl et al.   Communications Biology

Live Single-Cell Metabolomics With Matrix-Free Laser/Desorption Ionization Mass Spectrometry to Address Microalgal Physiology

(2019) Tim U. H. Baumeister et al.   Frontiers in Plant Science

Single-cell metabolomics by mass spectrometry: Advances, challenges, and future applications

(2019) Ahmed Ali et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Identification of bioactive metabolites using activity metabolomics

(2019) Markus M. Rinschen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid Heterogeneity between Astrocytes and Neurons Revealed by Single-Cell MALDI-MS Combined with Immunocytochemical Classification

(2019) Elizabeth K. Neumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microsampling Capillary Electrophoresis Mass Spectrometry Enables Single-Cell Proteomics in Complex Tissues: Developing Cell Clones in Live Xenopus laevis and Zebrafish Embryos

(2019) Camille Lombard-Banek et al.   ANALYTICAL CHEMISTRY

Metabolic Discrimination of Breast Cancer Subtypes at the Single-Cell Level by Multiple Microextraction Coupled with Mass Spectrometry

(2019) Ruihua Wang et al.   ANALYTICAL CHEMISTRY

Graphene quantum dots enhanced ToF-SIMS for single-cell imaging

(2019) Hao-Wen Li et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Integrating a generalized data analysis workflow with the Single-probe mass spectrometry experiment for single cell metabolomics

(2019) Renmeng Liu et al.   ANALYTICA CHIMICA ACTA

Trace, Machine Learning of Signal Images for Trace-Sensitive Mass Spectrometry: A Case Study from Single-Cell Metabolomics

(2019) Zhichao Liu et al.   ANALYTICAL CHEMISTRY

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Redesigning the T-probe for mass spectrometry analysis of online lysis of non-adherent single cells

(2019) Yanlin Zhu et al.   ANALYTICA CHIMICA ACTA

Ultrafast Microelectrophoresis: Behind Direct Mass Spectrometry Measurements of Proteins and Metabolites in Living Cell/Cells

(2019) Yuting Chen et al.   ANALYTICAL CHEMISTRY

Single-Cell-Derived Tumor-Sphere Formation and Drug-Resistance Assay Using an Integrated Microfluidics

(2019) Long Pang et al.   ANALYTICAL CHEMISTRY

Label-free Mass Cytometry for Unveiling Cellular Metabolic Heterogeneity

(2019) Huan Yao et al.   ANALYTICAL CHEMISTRY

Quantification of Drug Molecules in Live Single Cells Using the Single-Probe Mass Spectrometry Technique

(2019) Ning Pan et al.   ANALYTICAL CHEMISTRY

Single-cell Analysis Reveals a Preexisting Drug-Resistant Subpopulation in the Luminal Breast Cancer Subtype

(2019) Marta Prieto-Vila et al.   CANCER RESEARCH

NMR metabolomics: A look ahead

(2019) David S. Wishart   JOURNAL OF MAGNETIC RESONANCE

NMR Spectroscopy for Metabolomics Research

(2019) Abdul-Hamid Emwas et al.   Metabolites

Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community

(2019) Farhana R. Pinu et al.   Metabolites

Towards early monitoring of chemotherapy-induced drug resistance based on single cell metabolomics: Combining single-probe mass spectrometry with machine learning

(2019) Renmeng Liu et al.   ANALYTICA CHIMICA ACTA

ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells

(2019) Mingyang Liu et al.   GASTROENTEROLOGY

Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer

(2019) Qingfei Wang et al.   Nature Communications

Single-Cell Mass Spectrometry of Subpopulations Selected by Fluorescence Microscopy

(2018) Linwen Zhang et al.   ANALYTICAL CHEMISTRY

Quantitative Extraction and Mass Spectrometry Analysis at a Single-Cell Level

(2018) Ruichuan Yin et al.   ANALYTICAL CHEMISTRY

METLIN: A Technology Platform for Identifying Knowns and Unknowns

(2018) Carlos Guijas et al.   ANALYTICAL CHEMISTRY

Single-Cell Mass Spectrometry Approaches to Explore Cellular Heterogeneity

(2018) Linwen Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dean flow assisted cell ordering system for lipid profiling in single-cells using mass spectrometry

(2018) Qiushi Huang et al.   CHEMICAL COMMUNICATIONS

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast

(2018) Giuliano G. Stirparo et al.   DEVELOPMENT

Metabolomic analysis of mammalian cells and human tissue through one-pot two stage derivatizations using sheathless capillary electrophoresis-electrospray ionization-mass spectrometry

(2018) Tianjiao Huang et al.   JOURNAL OF CHROMATOGRAPHY A

Promises and pitfalls of untargeted metabolomics

(2018) Ilya Gertsman et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Single-Cell Mass Spectrometry Reveals Changes in Lipid and Metabolite Expression in RAW 264.7 Cells upon Lipopolysaccharide Stimulation

(2018) Bo Yang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Advances in mass spectrometry-based metabolomics for investigation of metabolites

(2018) Jun-Ling Ren et al.   RSC Advances

Metabolomic Fingerprints of Individual Algal Cells Using the Single-Probe Mass Spectrometry Technique

(2018) Mei Sun et al.   Frontiers in Plant Science

Sorting cells alters their redox state and cellular metabolome

(2018) Elizabeth M. Llufrio et al.   Redox Biology

Single-cell assay on microfluidic devices

(2018) Qiushi Huang et al.   ANALYST

T-Probe: An Integrated Microscale Device for Online In Situ Single Cell Analysis and Metabolic Profiling Using Mass Spectrometry

(2018) Renmeng Liu et al.   ANALYTICAL CHEMISTRY

Metabolomic Studies of Live Single Cancer Stem Cells Using Mass Spectrometry

(2018) Mei Sun et al.   ANALYTICAL CHEMISTRY

Tumour heterogeneity and metastasis at single-cell resolution

(2018) Devon A. Lawson et al.   NATURE CELL BIOLOGY

Discovery of rare cells from voluminous single cell expression data

(2018) Aashi Jindal et al.   Nature Communications

Single-cell imaging of phosphorus uptake shows that key harmful algae rely on different phosphorus sources for growth

(2018) Niels J. Schoffelen et al.   Scientific Reports

Metabolic Noise and Distinct Subpopulations Observed by Single Cell LAESI Mass Spectrometry of Plant Cells in situ

(2018) Sylwia A. Stopka et al.   Frontiers in Plant Science

Challenges, progress and promises of metabolite annotation for LC–MS-based metabolomics

(2018) Romanas Chaleckis et al.   CURRENT OPINION IN BIOTECHNOLOGY

Organelles – understanding noise and heterogeneity in cell biology at an intermediate scale

(2017) Amy Y. Chang et al.   JOURNAL OF CELL SCIENCE

microMS: A Python Platform for Image-Guided Mass Spectrometry Profiling

(2017) Troy J. Comi et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

NOREVA: normalization and evaluation of MS-based metabolomics data

(2017) Bo Li et al.   NUCLEIC ACIDS RESEARCH

Single-cell analysis by ambient mass spectrometry

(2017) Yunyun Yang et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Metabolomics: A Primer

(2017) Xiaojing Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

3D MALDI Mass Spectrometry Imaging of a Single Cell: Spatial Mapping of Lipids in the Embryonic Development of Zebrafish

(2017) Maria Emilia Dueñas et al.   Scientific Reports

Single-cell mass spectrometry with multi-solvent extraction identifies metabolic differences between left and right blastomeres in the 8-cell frog (Xenopus) embryo

(2016) Rosemary M. Onjiko et al.   ANALYST

Strategies for large-scale targeted metabolomics quantification by liquid chromatography-mass spectrometry

(2016) Juntuo Zhou et al.   ANALYST

Using Dicationic Ion-Pairing Compounds To Enhance the Single Cell Mass Spectrometry Analysis Using the Single-Probe: A Microscale Sampling and Ionization Device

(2016) Ning Pan et al.   ANALYTICAL CHEMISTRY

Single-Cell Metabolite Profiling of Stalk and Glandular Cells of Intact Trichomes with Internal Electrode Capillary Pressure Probe Electrospray Ionization Mass Spectrometry

(2016) Taiken Nakashima et al.   ANALYTICAL CHEMISTRY

Single-Cell Analysis Using Drop-on-Demand Inkjet Printing and Probe Electrospray Ionization Mass Spectrometry

(2016) Fengming Chen et al.   ANALYTICAL CHEMISTRY

Molecular Imaging of Biological Samples on Nanophotonic Laser Desorption Ionization Platforms

(2016) Sylwia A. Stopka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Geena 2, improved automated analysis of MALDI/TOF mass spectra

(2016) Paolo Romano et al.   BMC BIOINFORMATICS

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

Untargeted Metabolomics Strategies—Challenges and Emerging Directions

(2016) Alexandra C. Schrimpe-Rutledge et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Removing the bottlenecks of cell culture metabolomics: fast normalization procedure, correlation of metabolites to cell number, and impact of the cell harvesting method

(2016) Caroline Muschet et al.   Metabolomics

Data analysis strategies for targeted and untargeted LC-MS metabolomic studies: Overview and workflow

(2016) Eva Gorrochategui et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging

(2015) Melissa K. Passarelli et al.   ANALYTICAL CHEMISTRY

Energy Charge, Redox State, and Metabolite Turnover in Single Human Hepatocytes Revealed by Capillary Microsampling Mass Spectrometry

(2015) Linwen Zhang et al.   ANALYTICAL CHEMISTRY

The volumes and transcript counts of single cells reveal concentration homeostasis and capture biological noise

(2015) Hermannus Kempe et al.   MOLECULAR BIOLOGY OF THE CELL

Systems biology definition of the core proteome of metabolism and expression is consistent with high-throughput data

(2015) Laurence Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell mass spectrometry reveals small molecules that affect cell fates in the 16-cell embryo

(2015) Rosemary M. Onjiko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Situ metabolic analysis of single plant cells by capillary microsampling and electrospray ionization mass spectrometry with ion mobility separation

(2014) Linwen Zhang et al.   ANALYST

The Single-Probe: A Miniaturized Multifunctional Device for Single Cell Mass Spectrometry Analysis

(2014) Ning Pan et al.   ANALYTICAL CHEMISTRY

Biomolecular Imaging with a C60-SIMS/MALDI Dual Ion Source Hybrid Mass Spectrometer: Instrumentation, Matrix Enhancement, and Single Cell Analysis

(2014) Eric J. Lanni et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Subcellular Metabolite and Lipid Analysis of Xenopus laevis Eggs by LAESI Mass Spectrometry

(2014) Bindesh Shrestha et al.   PLoS One

Development of Isotope Labeling Liquid Chromatography–Mass Spectrometry for Metabolic Profiling of Bacterial Cells and Its Application for Bacterial Differentiation

(2013) Yiman Wu et al.   ANALYTICAL CHEMISTRY

Single-Cell Lipidomics: Characterizing and Imaging Lipids on the Surface of Individual Aplysia californica Neurons with Cluster Secondary Ion Mass Spectrometry

(2013) Melissa K. Passarelli et al.   ANALYTICAL CHEMISTRY

Metabolic Differences in Microbial Cell Populations Revealed by Nanophotonic Ionization

(2013) Bennett N. Walker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single cell heterogeneity

(2013) Batoul Y Abdallah et al.   CELL CYCLE

Single-Cell Metabolomics: Analytical and Biological Perspectives

(2013) R. Zenobi   SCIENCE

Observation of Subcellular Metabolite Gradients in Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry

(2012) Jessica A. Stolee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Using Cell-to-Cell Variability--A New Era in Molecular Biology

(2012) L. Pelkmans   SCIENCE

MetAlign 3.0: performance enhancement by efficient use of advances in computer hardware

(2011) Arjen Lommen et al.   Metabolomics

Single-Cell MALDI-MS as an Analytical Tool for Studying Intrapopulation Metabolic Heterogeneity of Unicellular Organisms

(2010) Andrea Amantonico et al.   ANALYTICAL CHEMISTRY

MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data

(2010) Tomáš Pluskal et al.   BMC BIOINFORMATICS

In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry

(2009) Bindesh Shrestha et al.   ANALYTICAL CHEMISTRY

Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics

(2009) Theodore Lapainis et al.   ANALYTICAL CHEMISTRY

mMass data miner: an open source alternative for mass spectrometric data analysis

(2008) Martin Strohalm et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY