Conjunctivitis in Dupilumab Clinical Trials for Adolescents with Atopic Dermatitis or Asthma

Incidence and risk factors for dupilumab associated ocular adverse events: a real‐life prospective study

(2020) A.T. Touhouche et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Goblet cell scarcity and conjunctival inflammation during treatment with dupilumab in patients with atopic dermatitis

(2019) D.S. Bakker et al.   BRITISH JOURNAL OF DERMATOLOGY

Evaluation of the ocular surface characteristics and Demodex infestation in paediatric and adult blepharokeratoconjunctivitis

(2019) Mengliang Wu et al.   BMC Ophthalmology

Conjunctivitis in dupilumab clinical trials

(2019) B. Akinlade et al.   BRITISH JOURNAL OF DERMATOLOGY

Dupilumab shows long-term safety and efficacy in moderate-to-severe atopic dermatitis patients enrolled in a phase 3 open-label extension study

(2019) Mette Deleuran et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Dupilumab in adolescents with uncontrolled moderate‐to‐severe atopic dermatitis: results from a phase II a open‐label trial and subsequent phase III open‐label extension

(2019) M.J. Cork et al.   BRITISH JOURNAL OF DERMATOLOGY

A Clinician’s Guide to the Recognition and Management of Dupilumab-Associated Conjunctivitis

(2019) Gaurav Agnihotri et al.   Drugs in research & development

Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis

(2019) Eric L. Simpson et al.   JAMA Dermatology

Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation

(2019) Audrey Le Floc’h et al.   ALLERGY

Clinically Meaningful Responses to Dupilumab in Adolescents with Uncontrolled Moderate-to-Severe Atopic Dermatitis: Post-hoc Analyses from a Randomized Clinical Trial

(2019) Amy S. Paller et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis

(2019) Ikuo Hirano et al.   GASTROENTEROLOGY

Conjunctivitis in patients with atopic dermatitis treated with dupilumab is associated with higher baseline serum levels of immunoglobulin E and thymus and activation-regulated chemokine but not clinical severity in a real-world setting

(2019) Hideaki Uchida et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis

(2019) Margitta Worm et al.   JAMA Dermatology

Higher mortality of adults with asthma: A 15-year follow-up of a population-based cohort

(2018) R. E. Lemmetyinen et al.   ALLERGY

Could conjunctivitis in patients with atopic dermatitis treated with dupilumab be caused by colonization with Demodex and increased interleukin-17 levels?

(2018) J.P. Thyssen   BRITISH JOURNAL OF DERMATOLOGY

Dupilumab with concomitant topical corticosteroid treatment in adults with atopic dermatitis with an inadequate response or intolerance to ciclosporin A or when this treatment is medically inadvisable: a placebo-controlled, randomized phase III clinical t

(2018) M. de Bruin-Weller et al.   BRITISH JOURNAL OF DERMATOLOGY

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

(2018) Klaus F. Rabe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

(2018) Mario Castro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conjunctivitis occurring in atopic dermatitis patients treated with dupilumab-clinical characteristics and treatment

(2018) Andreas Wollenberg et al.   Journal of Allergy and Clinical Immunology-In Practice

Risk Factors for Dupilumab-Associated Conjunctivitis in Patients With Atopic Dermatitis

(2018) Alison D. Treister et al.   JAMA Dermatology

Dupilumab-Induced Follicular Conjunctivitis

(2018) Elizabeth Shen et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Atopic dermatitis is associated with increased prevalence of multiple ocular comorbidities

(2018) Kishan Govind et al.   Journal of Allergy and Clinical Immunology-In Practice

Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis

(2017) Jacob P. Thyssen et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial

(2017) Andrew Blauvelt et al.   LANCET

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis

(2016) Claus Bachert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): A phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD)

(2016) Eric L. Simpson et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

(2016) Sally Wenzel et al.   LANCET

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial

(2016) Diamant Thaçi et al.   LANCET

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

(2016) Eric L. Simpson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug evaluation review: dupilumab in atopic dermatitis

(2015) Jennifer D Hamilton et al.   Immunotherapy

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis

(2014) Jennifer D. Hamilton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes

(2014) L. E. Macdonald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

(2014) A. J. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atopic keratoconjunctivitis: A review

(2013) Joseph J. Chen et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epidemiology of allergic conjunctivitis

(2011) Nelson Rosario et al.   Current Opinion in Allergy and Clinical Immunology

Atopic Dermatitis and Keratoconjunctivitis

(2010) Brett Bielory et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA