Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation

The Cytokines of Asthma

(2019) Bart N. Lambrecht et al.   IMMUNITY

Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis

(2019) Ikuo Hirano et al.   GASTROENTEROLOGY

A bispecific antibody strategy to target multiple type 2 cytokines in asthma

(2018) Marie Godar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

(2018) Klaus F. Rabe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

(2018) Mario Castro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial

(2018) Richard J Russell et al.   Lancet Respiratory Medicine

Tralokinumab for severe, uncontrolled asthma (STRATOS 1 and STRATOS 2): two randomised, double-blind, placebo-controlled, phase 3 clinical trials

(2018) Reynold A Panettieri et al.   Lancet Respiratory Medicine

Anti-interleukin 13 for asthma: stick or twist?

(2018) Brian Lipworth et al.   Lancet Respiratory Medicine

Commonality of the IL-4/IL-13 pathway in atopic diseases

(2017) Namita A. Gandhi et al.   Expert Review of Clinical Immunology

A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders

(2017) Erik Wambre et al.   Science Translational Medicine

Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia

(2017) Naoko Mato et al.   Scientific Reports

Novel Biologicals for the Treatment of Allergic Diseases and Asthma

(2016) Hern-Tze Tina Tan et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis

(2016) Claus Bachert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

(2016) Eugene R Bleecker et al.   LANCET

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

(2016) Sally Wenzel et al.   LANCET

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

(2016) J Mark FitzGerald et al.   LANCET

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial

(2016) Diamant Thaçi et al.   LANCET

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

(2016) Eric L. Simpson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials

(2016) Nicola A Hanania et al.   Lancet Respiratory Medicine

IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk

(2015) D. Kaur et al.   ALLERGY

History of interleukin-4

(2015) William E. Paul   CYTOKINE

Strategies targeting the IL-4/IL-13 axes in disease

(2015) Richard D. May et al.   CYTOKINE

IL-4 and IL-13 signaling in allergic airway disease

(2015) Naina Gour et al.   CYTOKINE

Targeting key proximal drivers of type 2 inflammation in disease

(2015) Namita A. Gandhi et al.   NATURE REVIEWS DRUG DISCOVERY

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

(2015) Mario Castro et al.   Lancet Respiratory Medicine

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis

(2014) Jennifer D. Hamilton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intravascular staining for discrimination of vascular and tissue leukocytes

(2014) Kristin G Anderson et al.   Nature Protocols

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes

(2014) L. E. Macdonald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

(2014) A. J. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Interleukin-13 in Asthma

(2013) Jonathan Corren   CURRENT ALLERGY AND ASTHMA REPORTS

Lung niches for the generation and maintenance of tissue-resident memory T cells

(2013) D L Turner et al.   Mucosal Immunology

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathogenic memory type Th2 cells in allergic inflammation

(2013) Yusuke Endo et al.   TRENDS IN IMMUNOLOGY

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

(2012) Zhiyong Yang et al.   IMMUNITY

Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production

(2011) Dawn C. Newcomb et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

(2010) C Edward Rose et al.   Cellular & Molecular Immunology

IgE, mast cells, basophils, and eosinophils

(2010) Kelly D. Stone et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY

Immune homeostasis in the respiratory tract and its impact on heterologous infection

(2009) Erika Wissinger et al.   SEMINARS IN IMMUNOLOGY