Sarcopenia – Molecular mechanisms and open questions

Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly

(2020) Ailin Bian et al.   BMC MUSCULOSKELETAL DISORDERS

Prdx6 Plays a Main Role in the Crosstalk between Aging and Metabolic Sarcopenia

(2020) Francesca Pacifici et al.   Antioxidants

The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia

(2019) Jacopo Vitale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sarcopenia: A Time for Action. An SCWD Position Paper

(2019) Juergen Bauer et al.   Journal of Cachexia Sarcopenia and Muscle

Differentially methylated gene patterns between age‐matched sarcopenic and non‐sarcopenic women

(2019) Lingxiao He et al.   Journal of Cachexia Sarcopenia and Muscle

Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans

(2019) Noémie Gensous et al.   Frontiers in Physiology

A review of telomere length in sarcopenia and frailty

(2018) Maria Lorenzi et al.   BIOGERONTOLOGY

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women

(2018) Caroline Van Nieuwpoort et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The cell biology of systemic insulin function

(2018) Victoria L. Tokarz et al.   JOURNAL OF CELL BIOLOGY

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

OUP accepted manuscript

(2018)   AGE AND AGEING

Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage

(2018) Raquel Fernando et al.   EXPERIMENTAL GERONTOLOGY

International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

(2018) Elsa Dent et al.   Journal of Nutrition Health & Aging

Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease

(2018) E. Sandra Chocron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of declining adaptive homeostasis in ageing

(2017) Laura C. D. Pomatto et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Role of Inflammation in Age-Related Sarcopenia

(2017) Sebastiaan Dalle et al.   Frontiers in Physiology

Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice

(2017) Ngoc Lu-Nguyen et al.   Molecular Therapy-Nucleic Acids

Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles

(2017) Elisia D. Tichy et al.   Stem Cell Reports

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

(2017) Annika Höhn et al.   Redox Biology

Skeletal muscle regeneration and impact of aging and nutrition

(2016) Carla Domingues-Faria et al.   AGEING RESEARCH REVIEWS

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis

(2016) Leslie M. Baehr et al.   Aging-US

Molecular and biological hallmarks of ageing

(2016) J. R. Aunan et al.   BRITISH JOURNAL OF SURGERY

Sarcopenic obesity: A probable risk factor for dose limiting toxicity during neo-adjuvant chemotherapy in oesophageal cancer patients

(2016) Poorna Anandavadivelan et al.   CLINICAL NUTRITION

Sarcopenia, sarcopenic obesity and inflammation: Results from the 1999–2004 National Health and Nutrition Examination Survey

(2016) John A. Batsis et al.   CLINICAL NUTRITION

Cellular proteostasis: degradation of misfolded proteins by lysosomes

(2016) M. P. Jackson et al.   Essays in Biochemistry

The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

(2016) Oren Rom et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sarcopenia: Prevalence and associated factors based on different suggested definitions in community-dwelling older adults

(2016) Hunkyung Kim et al.   Geriatrics & Gerontology International

Prevalence of sarcopenia in older Brazilians: A systematic review and meta-analysis

(2016) Juliano Bergamaschine Mata Diz et al.   Geriatrics & Gerontology International

Loss of muscle mass: Current developments in cachexia and sarcopenia focused on biomarkers and treatment

(2016) Cathleen Drescher et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Muscle structural assembly and functional consequences

(2016) Marco Narici et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Molecular networks in skeletal muscle plasticity

(2016) Hans Hoppeler   JOURNAL OF EXPERIMENTAL BIOLOGY

Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression

(2016) Katarzyna Goljanek-Whysall et al.   MAMMALIAN GENOME

Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways

(2016) Rachel Raynes et al.   MOLECULAR ASPECTS OF MEDICINE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Clinical Implications of Sarcopenic Obesity in Cancer

(2016) Isabella P. Carneiro et al.   Current Oncology Reports

microRNAs: Modulators of the underlying pathophysiology of sarcopenia?

(2015) David M. Brown et al.   AGEING RESEARCH REVIEWS

Calpain-dependent regulation of the skeletal muscle atrophy following unloading

(2015) Boris S. Shenkman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes

(2015) Maria Conte et al.   BIOGERONTOLOGY

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

Cachexia and sarcopenia: mechanisms and potential targets for intervention

(2015) Josep M Argilés et al.   CURRENT OPINION IN PHARMACOLOGY

Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting

(2015) Nathalie Bédard et al.   FASEB JOURNAL

The Epidemiology of Sarcopenia

(2015) Richard Matthew Dodds et al.   JOURNAL OF CLINICAL DENSITOMETRY

Exercise and Sarcopenia

(2015) Steven Phu et al.   JOURNAL OF CLINICAL DENSITOMETRY

Body Fat Distribution and Incident Cardiovascular Disease in Obese Adults

(2015) Ian J. Neeland et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prevalence of Sarcopenia and Associated Outcomes in the Clinical Setting

(2015) Sarah J. Peterson et al.   NUTRITION IN CLINICAL PRACTICE

Muscle protein turnover in the elderly and its potential contribution to the development of sarcopenia

(2015) Andrew J. Murton   PROCEEDINGS OF THE NUTRITION SOCIETY

Prevalence and definition of sarcopenia in community dwelling older people

(2015) D. Spira et al.   ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE

Sarcopenia and diabetes: Hyperglycemia is a risk factor for age-associated muscle mass and functional reduction

(2015) Hiroyuki Umegaki   Journal of Diabetes Investigation

Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

(2015) T. Scott Bowen et al.   Journal of Cachexia Sarcopenia and Muscle

The regulation of muscle mass by endogenous glucocorticoids

(2015) Theodore P. Braun et al.   Frontiers in Physiology

Oxidative proteome alterations during skeletal muscle ageing

(2015) Sofia Lourenço dos Santos et al.   Redox Biology

Telomere length is associated with decline in grip strength in older persons aged 65 years and over

(2014) Jean Woo et al.   AGE

Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)

(2014) A. J. Cruz-Jentoft et al.   AGE AND AGEING

Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation

(2014) Nicolas Tardif et al.   AGING CELL

SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner

(2014) Lance M. Bollinger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

(2014) Sue C. Bodine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways

(2014) J. Rodriguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Assessment and definition of lean body mass deficiency in the elderly

(2014) M J Müller et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III

(2014) J A Batsis et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

An ethanolic extract of Artemisia dracunculus L. regulates gene expression of ubiquitin–proteasome system enzymes in skeletal muscle: Potential role in the treatment of sarcopenic obesity

(2014) Heather Kirk-Ballard et al.   NUTRITION

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Current understanding of sarcopenia: possible candidates modulating muscle mass

(2014) Kunihiro Sakuma et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Are we closer to having drugs to treat muscle wasting disease?

(2014) John E. Morley et al.   Journal of Cachexia Sarcopenia and Muscle

Satellite cells in human skeletal muscle; from birth to old age

(2013) Lex B. Verdijk et al.   AGE

Age-dependent alteration in muscle regeneration: the critical role of tissue niche

(2013) Laura Barberi et al.   BIOGERONTOLOGY

Malnutrition, anorexia and cachexia in cancer patients: A mini-review on pathogenesis and treatment

(2013) Andrea Nicolini et al.   BIOMEDICINE & PHARMACOTHERAPY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

(2013) F. Demontis et al.   Disease Models & Mechanisms

GSK-3α is a central regulator of age-related pathologies in mice

(2013) Jibin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Plin2 Expression in Human Skeletal Muscle Is Associated with Sarcopenia and Muscle Weakness

(2013) Maria Conte et al.   PLoS One

Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting

(2012) Sudarsanareddy Lokireddy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Weight gain in long-term survivors of kidney or liver transplantation—Another paradigm of sarcopenic obesity?

(2012) Tatjana Schütz et al.   NUTRITION

What is dynapenia?

(2012) Brian C. Clark et al.   NUTRITION

p38β MAPK upregulates atrogin1/MAFbx by specific phosphorylation of C/EBPβ

(2012) Guohua Zhang et al.   Skeletal Muscle

Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB

(2011) Sandhya Sriram et al.   AGING CELL

Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

(2011) Leslie M. Baehr et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sarcopenia != Dynapenia

(2011) B. C. Clark et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models

(2011) Asaf A Qureshi et al.   Lipids in Health and Disease

Retraction: Myostatin Induces Degradation of Sarcomeric Proteins through a Smad3 Signaling Mechanism During Skeletal Muscle Wasting

(2011) Sudarsanareddy Lokireddy et al.   MOLECULAR ENDOCRINOLOGY

Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People

(2010) A. J. Cruz-Jentoft et al.   AGE AND AGEING

PSMB8 Encoding the β5i Proteasome Subunit Is Mutated in Joint Contractures, Muscle Atrophy, Microcytic Anemia, and Panniculitis-Induced Lipodystrophy Syndrome

(2010) Anil K. Agarwal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Slow twitch soleus muscle is not protected from sarcopenia in senescent rats

(2010) E.E. Carter et al.   EXPERIMENTAL GERONTOLOGY

Autophagy in skeletal muscle

(2010) Marco Sandri   FEBS LETTERS

Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

(2010) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury

(2010) Bartosz Szczesny et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sarcopenia Exacerbates Obesity-Associated Insulin Resistance and Dysglycemia: Findings from the National Health and Nutrition Examination Survey III

(2010) Preethi Srikanthan et al.   PLoS One

Proteasomal activity in skeletal muscle: A matter of assay design, muscle type, and age

(2009) Karl-Heinz Strucksberg et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy

(2009) Emanuele Marzetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion

(2009) Zully Pedrozo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

(2009) Stephanie Eva Wohlgemuth et al.   EXPERIMENTAL GERONTOLOGY

Chaperone-mediated autophagy in health and disease

(2009) Maria Kon et al.   FEBS LETTERS

Prevalence of sarcopenia and sarcopenic obesity in Korean adults: the Korean sarcopenic obesity study

(2009) T N Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

(2009) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Inverse correlation of protein oxidation and proteasome activity in liver and lung

(2009) Nicolle Breusing et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial iron accumulation with age and functional consequences

(2008) Arnold Y.  Seo et al.   AGING CELL

Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle

(2008) Thomas C. Vary et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Dietary protein recommendations and the prevention of sarcopenia

(2008) Douglas Paddon-Jones et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women

(2008) D. S. Hittel et al.   DIABETES

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

(2008) Adel Amirouche et al.   ENDOCRINOLOGY

MuRF1-dependent Regulation of Systemic Carbohydrate Metabolism as Revealed from Transgenic Mouse Studies

(2008) Stephanie Hirner et al.   JOURNAL OF MOLECULAR BIOLOGY

Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study

(2008) Carla MM Prado et al.   LANCET ONCOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

(2007) Béatrice Chabi et al.   AGING CELL

The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging

(2007) A HIONA   EXPERIMENTAL GERONTOLOGY