Programmed cell death in alcohol-associated liver disease

MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis

(2020) Xiaoqin Wu et al.   JOURNAL OF HEPATOLOGY

Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study

(2019) Gyongyi Szabo et al.   HEPATOLOGY

Inflammatory pathways in alcoholic steatohepatitis

(2019) Bin Gao et al.   JOURNAL OF HEPATOLOGY

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)

(2019) James M. Murphy   Cold Spring Harbor Perspectives in Biology

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

(2019) Zhou Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy in hepatic adaptation to stress

(2019) Younis Hazari et al.   JOURNAL OF HEPATOLOGY

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

(2018) Xiaojuan Chao et al.   GASTROENTEROLOGY

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression

(2018) Mi Jeong Heo et al.   GUT

Apoptosis and necroptosis in the liver: a matter of life and death

(2018) Robert F. Schwabe et al.   Nature Reviews Gastroenterology & Hepatology

Alcohol Use in Patients with Chronic Liver Disease

(2018) Daniel Fuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice

(2017) Fengjie Hao et al.   Cell Death & Disease

Does Hypoxia Cause Carcinogenic Iron Accumulation in Alcoholic Liver Disease (ALD)?

(2017) Inês Silva et al.   Cancers

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes

(2016) Laura E. Nagy et al.   GASTROENTEROLOGY

Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications

(2016) Wenhui Li et al.   JOURNAL OF HEPATOLOGY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

(2016) Shaogui Wang et al.   Oncotarget

The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway

(2016) Timothé Denaës et al.   Scientific Reports

Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB

(2015) Paul G. Thomes et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease

(2015) Jan Petrasek et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Inhibition of Apoptosis Protects Mice from Ethanol-Mediated Acceleration of Early Markers of CCl4-Induced Fibrosis but not Steatosis or Inflammation

(2012) Sanjoy Roychowdhury et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

(2012) Sanjoy Roychowdhury et al.   HEPATOLOGY

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

Hepatocyte Death: A Clear and Present Danger

(2010) Harmeet Malhi et al.   PHYSIOLOGICAL REVIEWS