Apoptotic mitochondria prime anti-tumour immunity

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

(2020) Chuanhui Han et al.   NATURE IMMUNOLOGY

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

(2020) Takahiro Yamazaki et al.   NATURE IMMUNOLOGY

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

(2019) Maria Esperanza Rodriguez-Ruiz et al.   OncoImmunology

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

(2017) Evangelos Giampazolias et al.   NATURE CELL BIOLOGY

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor

(2009) L. Moretti et al.   MOLECULAR CANCER THERAPEUTICS

M867, a Novel Selective Inhibitor of Caspase-3 Enhances Cell Death and Extends Tumor Growth Delay in Irradiated Lung Cancer Models

(2008) Kwang Woon Kim et al.   PLoS One