Redox signaling and Alzheimer’s disease: from pathomechanism insights to biomarker discovery and therapy strategy
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Title
Redox signaling and Alzheimer’s disease: from pathomechanism insights to biomarker discovery and therapy strategy
Authors
Keywords
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Journal
Biomarker Research
Volume 8, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-09-11
DOI
10.1186/s40364-020-00218-z
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Note: Only part of the references are listed.- Diabetes-Alzheimer´s disease link: Targeting mitochondrial dysfunction and redox imbalance
- (2020) Cristina Carvalho et al. ANTIOXIDANTS & REDOX SIGNALING
- Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease
- (2020) Tosha Williams et al. Molecular Neurodegeneration
- Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism
- (2020) Tanaka et al. MOLECULES
- Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer’s Disease Mouse Model
- (2020) Lin Lin et al. NEUROCHEMICAL RESEARCH
- Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-β complexes
- (2020) Jiyeon Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases
- (2020) Bahare Salehi et al. Journal of Clinical Medicine
- Prospective study of the effects of sport-related concussion on serum kynurenine pathway metabolites
- (2020) Timothy B. Meier et al. BRAIN BEHAVIOR AND IMMUNITY
- Active form of vitamin D analogue mitigates neurodegenerative changes in Alzheimer’s disease in rats by targeting Keap1/Nrf2 and MAPK-38p/ERK signaling pathways
- (2020) Shimaa Saad El-Din et al. STEROIDS
- Reactive oxygen species and their applications toward enhanced lipid accumulation in oleaginous microorganisms
- (2020) Sai Zhang et al. BIORESOURCE TECHNOLOGY
- Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/Axl NF κB/Nrf2 axis
- (2019) Dan-Qian Chen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Fructose-1,6-Bisphosphate Protects Hippocampal Rat Slices from NMDA Excitotoxicity
- (2019) Kamal M. Yakoub et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies
- (2019) Stephanie Andrade et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Role of N-Methyl-D-Aspartate Receptor Neurotransmission and Precision Medicine in Behavioral and Psychological Symptoms of Dementia
- (2019) Chieh-Hsin Lin et al. Frontiers in Pharmacology
- Cognitive Domains and Postdischarge Outcomes in Hospitalized Patients With Heart Failure
- (2019) Quan L. Huynh et al. Circulation-Heart Failure
- Resveratrol rescues tau-induced cognitive deficits and neuropathology in a mouse model of tauopathy
- (2019) Xiao-Ying Sun et al. Current Alzheimer Research
- Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis
- (2019) B. Teter et al. NEUROBIOLOGY OF DISEASE
- Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression
- (2019) Xinyi Wang et al. CELL RESEARCH
- Redox signaling in aging kidney and opportunity for therapeutic intervention through natural products
- (2019) Yuan-Yuan Chen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease
- (2019) Freek J. H. Sorgdrager et al. JOURNAL OF NEUROCHEMISTRY
- Recent advances from metabolomics and lipidomics application in alzheimer’s disease inspiring drug discovery
- (2019) Miroslava Cuperlovic-Culf et al. Expert Opinion on Drug Discovery
- Exercise enhances the effectiveness of vitamin D therapy in rats with Alzheimer’s disease: emphasis on oxidative stress and inflammation
- (2019) Engy Medhat et al. METABOLIC BRAIN DISEASE
- Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis
- (2019) Yongkang Zou et al. Cancer Discovery
- pLG72 levels increase in early phase of Alzheimer’s disease but decrease in late phase
- (2019) Chieh-Hsin Lin et al. Scientific Reports
- Systemic and central nervous system metabolic alterations in Alzheimer’s disease
- (2019) Vera van der Velpen et al. Alzheimers Research & Therapy
- Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1
- (2019) Yu An et al. Clinical Epigenetics
- Nanotechnology to improve the Alzheimer’s disease therapy with natural compounds
- (2019) Maria João Ramalho et al. Drug Delivery and Translational Research
- Coordination Complex Formation and Redox Properties of Kynurenic and Xanthurenic Acid Can Affect Brain Tissue Homeodynamics
- (2019) Lenka Kubicova et al. Antioxidants
- Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3
- (2019) Andrew J. Robinson et al. CANCER RESEARCH
- Effects of vitamin D in an animal model of Alzheimer’s disease: behavioral assessment with biochemical investigation of Hippocampus and serum
- (2019) Negar Mehri et al. METABOLIC BRAIN DISEASE
- DietaryAdvancedGlycationEnd Products–InducedCognitive Impairment in Aged ICR Mice: Protective Role of Quercetin
- (2019) Shengyi Yang et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Resveratrol in experimental Alzheimer’s disease models: A systematic review of preclinical studies
- (2019) Jia-Yue Chen et al. PHARMACOLOGICAL RESEARCH
- Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology
- (2018) Patricia Alonso-Andrés et al. BRAIN PATHOLOGY
- Fructose-1,6-bisphosphate preserves glucose metabolism integrity and reduces reactive oxygen species in the brain during experimental sepsis
- (2018) Anderson V. Catarina et al. BRAIN RESEARCH
- Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis
- (2018) Ming Wang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Lipid Biomarkers in Alzheimer's Disease
- (2018) Amira Zarrouk et al. Current Alzheimer Research
- 3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity
- (2018) Christos Papadimitriou et al. DEVELOPMENTAL CELL
- Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH Attenuate Renal Fibrosis via a Wnt/β-Catenin Pathway and Targeted Phosphorylation of smad3 Signaling
- (2018) Ming Wang et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Anthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes
- (2018) Humera Jahan et al. Medicinal Chemistry
- High performance plasma amyloid-β biomarkers for Alzheimer’s disease
- (2018) Akinori Nakamura et al. NATURE
- Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation
- (2018) Hua Chen et al. PHYTOMEDICINE
- Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not
- (2018) Shaoming Sang et al. Alzheimers Research & Therapy
- Quercetin nanoparticles with enhanced bioavailability as multifunctional agents toward amyloid induced neurotoxicity
- (2018) Qiusen Han et al. Journal of Materials Chemistry B
- Low Serum Vitamin D Concentrations in Alzheimer's Disease: A Systematic Review and Meta-Analysis
- (2018) Cedric Annweiler et al. JOURNAL OF ALZHEIMERS DISEASE
- Metabolomic Signatures in Peripheral Blood Associated with Alzheimer's Disease Amyloid-β-Induced Neuroinflammation
- (2018) Eosu Kim et al. JOURNAL OF ALZHEIMERS DISEASE
- Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina
- (2018) Jing Guo et al. Neuroscience Bulletin
- A novel synthesis of selenium nanoparticles encapsulated PLGA nanospheres with curcumin molecules for the inhibition of amyloid β aggregation in Alzheimer's disease
- (2018) Xinlong Huo et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- A Novel Perspective Linkage Between Kidney Function and Alzheimer’s Disease
- (2018) Yan Shi et al. Frontiers in Cellular Neuroscience
- Neuromodulatory Effects of Guanine-Based Purines in Health and Disease
- (2018) Carla I. Tasca et al. Frontiers in Cellular Neuroscience
- Dietary Modulation of Oxidative Stress in Alzheimer’s Disease
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Oscarellin, an Anthranilic Acid Derivative from a Philippine Sponge, Oscarella stillans, as an Inhibitor of Inflammatory Cytokines in Macrophages
- (2017) Ii-Seul Kwon et al. JOURNAL OF NATURAL PRODUCTS
- Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
- (2017) Valery L Feigin et al. LANCET NEUROLOGY
- Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes
- (2017) Wei Qiang et al. NATURE
- Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging
- (2017) Chieh-Hsin Lin et al. Scientific Reports
- Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study
- (2017) Stuart G. Snowden et al. PLOS MEDICINE
- Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression
- (2017) Baoshang Zhou et al. Redox Biology
- Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial
- (2017) Chieh-Hsin Lin et al. BIOLOGICAL PSYCHIATRY
- Vitamin E and Enzymatic/Oxidative Stress-Driven Oxysterols in Amnestic Mild Cognitive Impairment Subtypes and Alzheimer's Disease
- (2017) Luigi Iuliano et al. JOURNAL OF ALZHEIMERS DISEASE
- Homocysteine, B Vitamins, and Cognitive Impairment
- (2016) A. David Smith et al. Annual Review of Nutrition
- Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease
- (2016) Shao-wei Wang et al. BEHAVIOURAL BRAIN RESEARCH
- Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases
- (2016) Ajaikumar B Kunnumakkara et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cerebrospinal fluid lactate levels and brain [18F]FDG PET hypometabolism within the default mode network in Alzheimer’s disease
- (2016) Claudio Liguori et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Natural Products as Sources of New Drugs from 1981 to 2014
- (2016) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Unrecognized Cognitive Impairment and Its Effect on Heart Failure Readmissions of Elderly Adults
- (2016) Kathryn S. Agarwal et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Guanosine Prevents Anhedonic-Like Behavior and Impairment in Hippocampal Glutamate Transport Following Amyloid-β1–40 Administration in Mice
- (2016) Débora Lanznaster et al. MOLECULAR NEUROBIOLOGY
- Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites
- (2016) Carlo Breda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model
- (2016) Tong Li et al. Nature Communications
- A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer's disease
- (2016) Naijing Li et al. Journal of Ginseng Research
- Measurement of Blood Thiamine Metabolites for Alzheimer's Disease Diagnosis
- (2016) Xiaoli Pan et al. EBioMedicine
- Simultaneous determination of 18 d-amino acids in rat plasma by an ultrahigh-performance liquid chromatography-tandem mass spectrometry method: application to explore the potential relationship between Alzheimer’s disease and d-amino acid level alterations
- (2015) Yuping Xing et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Gout and the risk of Alzheimer's disease: a population-based, BMI-matched cohort study
- (2015) Na Lu et al. ANNALS OF THE RHEUMATIC DISEASES
- The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders
- (2015) Gerwyn Morris et al. MOLECULAR NEUROBIOLOGY
- Inverse Association Between Serum Uric Acid Levels and Alzheimer’s Disease Risk
- (2015) Na Du et al. MOLECULAR NEUROBIOLOGY
- Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer’s disease
- (2015) Li Wu et al. Nano Research
- Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology
- (2015) Elisa Isopi et al. NEUROBIOLOGY OF DISEASE
- A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
- (2015) R. Scott Turner et al. NEUROLOGY
- Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape
- (2015) Antero Salminen et al. PROGRESS IN NEUROBIOLOGY
- Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
- (2015) Antonella Sgarbossa et al. Nutrients
- Characterization of Aldh2 -/- mice as an age-related model of cognitive impairment and Alzheimer’s disease
- (2015) Yohan D’Souza et al. Molecular Brain
- Cholesterol and metal ions in Alzheimer's disease
- (2014) Hyuck Jin Lee et al. CHEMICAL SOCIETY REVIEWS
- Inhibition of Amyloid Fibril Growth and Dissolution of Amyloid Fibrils by Curcumin-Gold Nanoparticles
- (2014) Sharbari Palmal et al. CHEMISTRY-A EUROPEAN JOURNAL
- Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease
- (2014) Maurice W. Dysken et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The Involvement of Lipids in Alzheimer's Disease
- (2014) Wei Ling Florence Lim et al. Journal of Genetics and Genomics
- CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease
- (2014) C Liguori et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- The role of iron in brain ageing and neurodegenerative disorders
- (2014) Roberta J Ward et al. LANCET NEUROLOGY
- Plasma phospholipids identify antecedent memory impairment in older adults
- (2014) Mark Mapstone et al. NATURE MEDICINE
- Polyunsaturated fatty acids and their metabolites in brain function and disease
- (2014) Richard P. Bazinet et al. NATURE REVIEWS NEUROSCIENCE
- Vitamin D and the risk of dementia and Alzheimer disease
- (2014) T. J. Littlejohns et al. NEUROLOGY
- Positive oxidative stress in aging and aging-related disease tolerance
- (2014) Liang-Jun Yan Redox Biology
- Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease
- (2013) Masha G. Savelieff et al. ACS Chemical Biology
- Benzoate, a D-Amino Acid Oxidase Inhibitor, for the Treatment of Early-Phase Alzheimer Disease: A Randomized, Double-Blind, Placebo-Controlled Trial
- (2013) Chieh-Hsin Lin et al. BIOLOGICAL PSYCHIATRY
- Forecasting the Impact of Heart Failure in the United States
- (2013) Paul A. Heidenreich et al. Circulation-Heart Failure
- Effect of hypoxanthine, antioxidants and allopurinol on cholinesterase activities in rats
- (2013) Morgahna Nathalie Wamser et al. JOURNAL OF NEURAL TRANSMISSION
- Structural basis of kynurenine 3-monooxygenase inhibition
- (2013) Marta Amaral et al. NATURE
- CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
- (2013) Frederick J Sheedy et al. NATURE IMMUNOLOGY
- Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease
- (2013) Xiao-Tian Huang et al. NEUROBIOLOGY OF AGING
- Chronic Kidney Disease and Cognitive Impairment: A Systematic Review and Meta-Analysis
- (2012) Thorleif Etgen et al. AMERICAN JOURNAL OF NEPHROLOGY
- Metal-associated amyloid-β species in Alzheimer's disease
- (2012) Amit S Pithadia et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- An expanding range of targets for kynurenine metabolites of tryptophan
- (2012) Trevor W. Stone et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
- (2012) John M Ringman et al. Alzheimers Research & Therapy
- Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
- (2011) Daniel Zwilling et al. CELL
- Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation
- (2011) Annadora J. Bruce-Keller et al. NEUROBIOLOGY OF DISEASE
- A phase II trial of huperzine A in mild to moderate Alzheimer disease
- (2011) M. S. Rafii et al. NEUROLOGY
- Hyperhomocysteinemia Increases β-Amyloid by Enhancing Expression of γ-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain
- (2009) Chang-E Zhang et al. AMERICAN JOURNAL OF PATHOLOGY
- High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease
- (2008) Paul S. Aisen JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Lessons About Brain Vascular Disease From Another Pulsating Organ, the Kidney
- (2007) Stephen L. Seliger et al. STROKE
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