New emerging targets in cancer immunotherapy: the role of GITR

GITR shapes humoral immunity by controlling the balance between follicular T helper cells and regulatory T follicular cells

(2020) Anna E. Oja et al.   IMMUNOLOGY LETTERS

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Phase 1 study of MK-4166, an anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) antibody, as monotherapy or with pembrolizumab (pembro) in patients (pts) with advanced solid tumors.

(2019) Kyriakos P. Papadopoulos et al.   JOURNAL OF CLINICAL ONCOLOGY

Rational design of anti-GITR-based combination immunotherapy

(2019) Roberta Zappasodi et al.   NATURE MEDICINE

Characterization and comparison of GITR expression in solid tumors

(2019) Luis Vence et al.   CLINICAL CANCER RESEARCH

Local Administration of GITR Agonistic Antibody Induces a Stronger Antitumor Immunity than Systemic Delivery

(2019) Kenta Narumi et al.   Scientific Reports

Glucocorticoid-induced TNFR-related gene (GITR) as a therapeutic target for immunotherapy

(2018) Carlo Riccardi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

GITR Agonism Enhances Cellular Metabolism to Support CD8+ T-cell Proliferation and Effector Cytokine Production in a Mouse Tumor Model

(2018) Simran S. Sabharwal et al.   Cancer Immunology Research

Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

(2018) Jonathan E. Schoenhals et al.   Frontiers in Immunology

Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor–related protein agonist AMG 228 in patients with advanced solid tumors

(2018) Ben Tran et al.   Journal for ImmunoTherapy of Cancer

1154PA phase I study of MEDI1873, a novel GITR agonist, in advanced solid tumors

(2018) C S Denlinger et al.   ANNALS OF ONCOLOGY

Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy

(2016) Ashley E. Mahne et al.   CANCER RESEARCH

Rationale for anti-GITR cancer immunotherapy

(2016) Deborah A. Knee et al.   EUROPEAN JOURNAL OF CANCER

GITR+ regulatory T cells in the treatment of autoimmune diseases

(2015) Maria Grazia Petrillo et al.   AUTOIMMUNITY REVIEWS

Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+Regulatory T Cells Are Depleted

(2015) Young H. Kim et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells

(2015) Il-Kyu Kim et al.   NATURE MEDICINE

Comparison of circulating and intratumoral regulatory T cells in patients with renal cell carcinoma

(2015) Gati Asma et al.   TUMOR BIOLOGY

Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection

(2014) Derek L. Clouthier et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs

(2014) Lei Lu et al.   Journal of Translational Medicine

Combination of Alphavirus Replicon Particle-Based Vaccination with Immunomodulatory Antibodies: Therapeutic Activity in the B16 Melanoma Mouse Model and Immune Correlates

(2014) F. Avogadri et al.   Cancer Immunology Research

Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy

(2014) David A Schaer et al.   Journal for ImmunoTherapy of Cancer

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

(2013) Yannick Bulliard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intratumoral regulatory T cells with higher prevalence and more suppressive activity in hepatocellular carcinoma patients

(2013) Han Wu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Correction: Secreted and Transmembrane 1A Is a Novel Co-Stimulatory Ligand

(2013) Duncan Howie et al.   PLoS One

GITR Pathway Activation Abrogates Tumor Immune Suppression through Loss of Regulatory T-cell Lineage Stability

(2013) D. A. Schaer et al.   Cancer Immunology Research

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

(2012) Alexander Pedroza-Gonzalez et al.   HEPATOLOGY

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

(2012) Kuibeom Ko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15-Dependent Upregulation of GITR on CD8 Memory Phenotype T Cells in the Bone Marrow Relative to Spleen and Lymph Node Suggests the Bone Marrow as a Site of Superior Bioavailability of IL-15

(2012) L. M. Snell et al.   JOURNAL OF IMMUNOLOGY

Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

(2010) David Coe et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

(2010) J. Mitsui et al.   CLINICAL CANCER RESEARCH

CD8 T Cell-Intrinsic GITR Is Required for T Cell Clonal Expansion and Mouse Survival following Severe Influenza Infection

(2010) L. M. Snell et al.   JOURNAL OF IMMUNOLOGY

Combining T-cell Vaccination and Application of Agonistic Anti-GITR mAb (DTA-1) Induces Complete Eradication of HPV Oncogene Expressing Tumors in Mice

(2010) Corinna Hoffmann et al.   JOURNAL OF IMMUNOTHERAPY

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

(2010) Adam D. Cohen et al.   PLoS One

Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer

(2009) Christoph Loddenkemper et al.   CANCER SCIENCE

Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity

(2008) K. M. Baltz et al.   BLOOD

Regulatory T Cell-Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

(2008) H. Nishikawa et al.   CANCER RESEARCH

Structural basis for ligand-mediated mouse GITR activation

(2008) Z. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA