Some Suggestions from PK/PD Principles to Contain Resistance in the Clinical Setting—Focus on ICU Patients and Gram-Negative Strains

Meropenem/Vaborbactam versus Ceftazidime/Avibactam for Treatment of Carbapenem-Resistant Enterobacteriaceae Infections

(2020) Renee Ackley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

(2020) A. Abdulla et al.   BMC INFECTIOUS DISEASES

New treatment options for multiresistant gram negatives

(2020) David L. Paterson et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Impact of augmented renal clearance (ARC) on the pharmacokinetics of linezolid: Advantages of continuous infusion from a PK/PD perspective

(2020) Helena Barrasa et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Methodological features of clinical pharmacokinetic–pharmacodynamic studies of antibacterials and antifungals: a systematic review

(2020) Alexandra McAleenan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

How to design a study to evaluate therapeutic drug monitoring in infectious diseases?

(2020) A.-G. Märtson et al.   CLINICAL MICROBIOLOGY AND INFECTION

Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012–2017

(2020) John A. Jernigan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis: A Randomized Trial

(2020) Evdoxia Kyriazopoulou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study

(2020) Liesbet De Bus et al.   INTENSIVE CARE MEDICINE

Antimicrobial Treatment Duration in Sepsis and Serious Infections

(2020) Lindsay M Busch et al.   JOURNAL OF INFECTIOUS DISEASES

Bezlotoxumab for Preventing Recurrent Clostridioides difficile Infection: A Narrative Review from Pathophysiology to Clinical Studies

(2020) Daniele Roberto Giacobbe et al.   Infectious Diseases and Therapy

Phage Therapy in the Resistance Era: Where Do We Stand and Where Are We Going?

(2020) Tiffany Luong et al.   CLINICAL THERAPEUTICS

De-escalation of antimicrobial therapy in ICU settings with high prevalence of multidrug-resistant bacteria: a multicentre prospective observational cohort study in patients with sepsis or septic shock

(2020) Christina Routsi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Augmented Renal Clearance

(2019) Aaron M. Cook et al.   PHARMACOTHERAPY

International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP)

(2019) Brian T. Tsuji et al.   PHARMACOTHERAPY

Breakpoint determination when multiple organisms are tested for effect targets

(2019) G.L. Drusano et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Generating robust and informative nonclinical in vitro and in vivo bacterial infection model efficacy data to support translation to humans

(2019) Jürgen B. Bulitta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance

(2019) Chandradhish Ghosh et al.   TRENDS IN MICROBIOLOGY

What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review

(2019) Chandra Datta Sumi et al.   CLINICAL PHARMACOKINETICS

Optimizing Vancomycin Use Through 2‐Point AUC‐Based Therapeutic Drug Monitoring in Pediatric Patients

(2019) Pintip Suchartlikitwong et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacologic optimization of antibiotics for Gram-negative infections

(2019) Christian M. Gill et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Therapeutic drug monitoring-guided continuous infusion of piperacillin/tazobactam significantly improves pharmacokinetic target attainment in critically ill patients: a retrospective analysis of four years of clinical experience

(2019) Daniel C. Richter et al.   INFECTION

Efficacy and safety of high-dose tigecycline for the treatment of infectious diseases

(2019) Jinhong Gong et al.   MEDICINE

Pharmacokinetics/Pharmacodynamics of β-Lactams and Therapeutic Drug Monitoring: From Theory to Practical Issues in the Intensive Care Unit

(2019) Paul Williams et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

In vitro and in vivo assessment of the antibacterial activity of colistin alone and/or in combination with other antibiotics against A. baumannii and E. coli

(2019) Yale Wang et al.   Journal of Global Antimicrobial Resistance

The Pharmacodynamics of Prolonged Infusion β-Lactams for the Treatment of Pseudomonas aeruginosa Infections: A Systematic Review

(2019) Abrar K. Thabit et al.   CLINICAL THERAPEUTICS

Towards Rapid Sepsis Diagnosis and Patients Stratification: What’s New From Microbiology and Omics Science

(2019) Davide Mangioni et al.   JOURNAL OF INFECTIOUS DISEASES

Diagnostic and medical needs for therapeutic drug monitoring of antibiotics

(2019) Claude Mabilat et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Pneumonia and Renal Replacement Therapy Are Risk Factors for Ceftazidime-Avibactam Treatment Failures and Resistance among Patients with Carbapenem-Resistant Enterobacteriaceae Infections

(2018) Ryan K. Shields et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections?

(2018) Anouk E. Muller et al.   DRUGS

Individualising Therapy to Minimize Bacterial Multidrug Resistance

(2018) A. J. Heffernan et al.   DRUGS

The GISA call to action for the appropriate use of antimicrobials and the control of antimicrobial resistance in Italy

(2018) Francesco Menichetti et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pharmacokinetic and Pharmacodynamic Considerations of Antibiotics of Last Resort in Treating Gram-Negative Infections in Adult Critically Ill Patients

(2018) Mojdeh S. Heavner et al.   Current Infectious Disease Reports

Renal Dosing of Antibiotics: Are We Jumping the Gun?

(2018) Ryan L Crass et al.   CLINICAL INFECTIOUS DISEASES

Frequency and antimicrobial susceptibility of Gram-negative bacteria isolated from patients with pneumonia hospitalized in ICUs of US medical centres (2015–17)

(2018) Helio S Sader et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The exploration of population pharmacokinetic model for meropenem in augmented renal clearance and investigation of optimum setting of dose

(2018) Tatsuro Tamatsukuri et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Pharmacokinetics/Pharmacodynamics of Vaborbactam, a Novel Beta-Lactamase Inhibitor, in Combination with Meropenem

(2018) David C. Griffith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients

(2018) Aaron J. Heffernan et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Ceftolozane/tazobactam for the treatment of serious P. aeruginosa infections: a multicenter nationwide clinical experience

(2018) Matteo Bassetti et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Suboptimal Clinical Response Rates with Newer Antibiotics Among Patients with Moderate Renal Impairment: Review of the Literature and Potential Pharmacokinetic and Pharmacodynamic Considerations for Observed Findings

(2018) Monique R. Bidell et al.   PHARMACOTHERAPY

Predicting and preventing antimicrobial resistance utilizing pharmacodynamics: part II Gram-negative bacteria

(2017) Kamilia Abdelraouf et al.   Expert Opinion on Drug Metabolism & Toxicology

The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

(2017) T. Tängdén et al.   INTENSIVE CARE MEDICINE

Pharmacodynamics of minocycline against Acinetobacter baumannii studied in a pharmacokinetic model of infection

(2017) Wadha A. Alfouzan et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Determining β-lactam exposure threshold to suppress resistance development in Gram-negative bacteria

(2017) Vincent H. Tam et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis

(2017) Christopher W. Seymour et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Drug Monitoring of Biopharmaceuticals May Benefit From Pharmacokinetic and Pharmacokinetic–Pharmacodynamic Modeling

(2017) Christophe Passot et al.   THERAPEUTIC DRUG MONITORING

Augmented Renal Clearance in Critical Illness: An Important Consideration in Drug Dosing

(2017) Sherif Mahmoud et al.   Pharmaceutics

Clinical and economic impact of antibiotic resistance in developing countries: A systematic review and meta-analysis

(2017) Raspail Carrel Founou et al.   PLoS One

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

(2016) Brian T. Tsuji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance

(2016) Soon-Ee Cheah et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multicenter Prospective Cohort Study of Renal Failure in Patients Treated with Colistin versus Polymyxin B

(2016) Maria Helena Rigatto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy and Safety of Ceftazidime-Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-abdominal Infection: Results From a Randomized, Controlled, Double-Blind, Phase 3 Program

(2016) John E. Mazuski et al.   CLINICAL INFECTIOUS DISEASES

De-escalation of empiric antibiotics in patients with severe sepsis or septic shock: A meta-analysis

(2016) Ying Guo et al.   HEART & LUNG

Prolonged administration of β-lactam antibiotics – a comprehensive review and critical appraisal

(2016) M Osthoff et al.   SWISS MEDICAL WEEKLY

Optimizing Antibiotic Dosing Strategies for the Treatment of Gram-negative Infections in the Era of Resistance

(2016) Marguerite L. Monogue et al.   Expert Review of Clinical Pharmacology

Does Critical Illness Change Levofloxacin Pharmacokinetics?

(2015) Jason A. Roberts et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacodynamics of Fosfomycin: Insights into Clinical Use for Antimicrobial Resistance

(2015) F. Docobo-Pérez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Linezolid extracorporeal removal during haemodialysis with high cut-off membrane in critically ill patients

(2015) Gianluca Villa et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort

(2015) Mohd H. Abdul-Aziz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Phase 1 study assessing the steady-state concentration of ceftazidime and avibactam in plasma and epithelial lining fluid following two dosing regimens

(2015) David P. Nicolau et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Emerging Issues in Gram-Negative Bacterial Resistance

(2015) Shawn Vasoo et al.   MAYO CLINIC PROCEEDINGS

Applying Pharmacokinetic/Pharmacodynamic Principles in Critically Ill Patients: Optimizing Efficacy and Reducing Resistance Development

(2015) Mohd Abdul-Aziz et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Antibiotic Dosing in Critically Ill Patients Receiving CRRT: Underdosing is Overprevalent

(2015) Susan J. Lewis et al.   SEMINARS IN DIALYSIS

Fluoroquinolone- and ceftriaxone-based therapy of community-acquired pneumonia in hospitalized patients: The risk of subsequent isolation of multidrug-resistant organisms

(2014) Robert C. Goldstein et al.   AMERICAN JOURNAL OF INFECTION CONTROL

Simplified Equations Using Two Concentrations To Calculate Area under the Curve for Antimicrobials with Concentration-Dependent Pharmacodynamics: Daptomycin as a Motivating Example

(2014) Manjunath P. Pai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Relationship between Ceftolozane-Tazobactam Exposure and Selection for Pseudomonas aeruginosa Resistance in a Hollow-Fiber Infection Model

(2014) Brian D. VanScoy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?

(2014) Gloria Wong et al.   BMC INFECTIOUS DISEASES

Therapeutic drug monitoring of antibiotics

(2014) Joseph S Bertino   LANCET INFECTIOUS DISEASES

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

(2014) Jason A Roberts et al.   LANCET INFECTIOUS DISEASES

Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Ceftolozane in anIn VitroInfection Model

(2013) Brian VanScoy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of Bolus Dosing versus Continuous Infusion of Piperacillin and Tazobactam on the Development of Antimicrobial Resistance in Pseudomonas aeruginosa

(2013) T. W. Felton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Augmented Renal Clearance in the ICU

(2013) Andrew A. Udy et al.   CRITICAL CARE MEDICINE

Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy

(2013) Barbara O.M. Claus et al.   JOURNAL OF CRITICAL CARE

Retooling the Creatinine Clearance Equation to Estimate Kinetic GFR when the Plasma Creatinine Is Changing Acutely

(2013) S. Chen   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dosing Regimen Matters: the Importance of Early Intervention and Rapid Attainment of the Pharmacokinetic/Pharmacodynamic Target

(2012) Marilyn N. Martinez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Benchmarking Therapeutic Drug Monitoring Software: A Review of Available Computer Tools

(2012) Aline Fuchs et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients

(2012) Zoe E. Athanassa et al.   INTENSIVE CARE MEDICINE

Comparative Activity of Carbapenem Testing (COMPACT) study in Germany

(2012) Giuseppe Valenza et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Resistance Emergence Mechanism and Mechanism of Resistance Suppression by Tobramycin for Cefepime for Pseudomonas aeruginosa

(2011) G. L. Drusano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Procalcitonin Algorithms for Antibiotic Therapy Decisions

(2011) Philipp Schuetz   ARCHIVES OF INTERNAL MEDICINE

Conserving antibiotics for the future: New ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective

(2011) Johan W. Mouton et al.   DRUG RESISTANCE UPDATES

Procalcitonin Levels Predict Bacteremia in Patients With Community-Acquired Pneumonia

(2010) Fabian Müller et al.   CHEST

Therapeutic drug monitoring of β-lactams in critically ill patients: proof of concept

(2010) Jason A. Roberts et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Extracellular concentrations of fosfomycin in lung tissue of septic patients

(2010) V. Matzi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Monte Carlo simulations: maximizing antibiotic pharmacokinetic data to optimize clinical practice for critically ill patients

(2010) J. A. Roberts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models

(2010) R. V. Dudhani et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

(2010) Lila Bouadma et al.   LANCET

Population Pharmacokinetic Analysis of Colistin Methanesulfonate and Colistin after Intravenous Administration in Critically Ill Patients with Infections Caused by Gram-Negative Bacteria

(2009) D. Plachouras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials

(2009) Chiara Adembri et al.   CLINICAL PHARMACOKINETICS

Review of studies of the impact on Gram-negative bacterial resistance on outcomes in the intensive care unit*

(2009) Andrew F. Shorr   CRITICAL CARE MEDICINE

In vivo dynamics of carbapenem-resistant Pseudomonas aeruginosa selection after suboptimal dosing

(2009) Vincent H. Tam et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Pharmacodynamic Modeling of Aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: Identifying Dosing Regimens To Suppress Resistance Development

(2008) V. H. Tam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial breakpoints for Gram-negative aerobic bacteria based on pharmacokinetic–pharmacodynamic models with Monte Carlo simulation

(2008) Christopher R. Frei et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY