The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

New Regimen for Continuous Infusion of Vancomycin in Critically Ill Patients

(2016) Stefano Cristallini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of Policies on the Rise in Sepsis Incidence, 2000–2010

(2016) Shruti K. Gohil et al.   CLINICAL INFECTIOUS DISEASES

Effect of different renal function on antibacterial effects of piperacillin againstPseudomonas aeruginosaevaluated via the hollow-fibre infection model and mechanism-based modelling

(2016) Phillip J. Bergen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Population pharmacokinetics and pharmacodynamics of teicoplanin in neonates: making better use of C-reactive protein to deliver individualized therapy

(2016) V. Ramos-Martín et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

What about confidence intervals? A word of caution when interpreting PTA simulations

(2016) Pieter Colin et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs

(2016) Anders N. Kristoffersson et al.   PHARMACEUTICAL RESEARCH

Microdialysis as a way to measure antibiotics concentration in tissues

(2016) Sandrine Marchand et al.   PHARMACOLOGICAL RESEARCH

Therapeutic drug monitoring of anti-infective agents in critically ill patients

(2016) Nynke G. L. Jager et al.   Expert Review of Clinical Pharmacology

Use of old antibiotics now and in the future from a pharmacokinetic/pharmacodynamic perspective

(2015) A.E. Muller et al.   CLINICAL MICROBIOLOGY AND INFECTION

Cefepime free minimum concentration to minimum inhibitory concentration (fCmin/MIC) ratio predicts clinical failure in patients with Gram-negative bacterial pneumonia

(2015) Samuel L. Aitken et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients

(2015) Jason A. Roberts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Population Pharmacokinetics of Teicoplanin in Children

(2014) V. Ramos-Martín et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparison of the Accuracy and Precision of Pharmacokinetic Equations To Predict Free Meropenem Concentrations in Critically Ill Patients

(2014) Gloria Wong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Population Pharmacokinetics and Toxicodynamics of Linezolid

(2014) Lauren M. Boak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vancomycin-Associated Nephrotoxicity in the Critically Ill

(2014) Timothy P. Hanrahan et al.   CRITICAL CARE MEDICINE

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

(2014) Jason A Roberts et al.   LANCET INFECTIOUS DISEASES

Microdialysis Study of Cefotaxime Cerebral Distribution in Patients with Acute Brain Injury

(2013) Claire Dahyot-Fizelier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing?

(2013) Michael N. Neely et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combination therapy for carbapenem-resistant Gram-negative bacteria

(2013) Alexandre P Zavascki et al.   Expert Review of Anti-Infective Therapy

Clinical implications of antibiotic pharmacokinetic principles in the critically ill

(2013) Andrew A. Udy et al.   INTENSIVE CARE MEDICINE

Population Pharmacokinetics of Fusidic Acid: Rationale for Front-Loaded Dosing Regimens Due to Autoinhibition of Clearance

(2012) Jürgen B. Bulitta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Front-Loaded Linezolid Regimens Result in Increased Killing and Suppression of the Accessory Gene Regulator System of Staphylococcus aureus

(2012) Brian T. Tsuji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fundamentals of Population Pharmacokinetic Modelling

(2012) Tony K. L. Kiang et al.   CLINICAL PHARMACOKINETICS

Improving antibiotic dosing in special situations in the ICU

(2012) Janattul-Ain Jamal et al.   Current Opinion in Critical Care

Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations

(2012) B. T. Tsuji et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation

(2012) Kiran Shekar et al.   JOURNAL OF CRITICAL CARE

Clinically Relevant Plasma Concentrations of Colistin in Combination with Imipenem Enhance Pharmacodynamic Activity against Multidrug-Resistant Pseudomonas aeruginosa at Multiple Inocula

(2011) Phillip J. Bergen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vancomycin Dosing in Critically Ill Patients: Robust Methods for Improved Continuous-Infusion Regimens

(2011) Jason A. Roberts et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Penetration of Meropenem into Epithelial Lining Fluid of Patients with Ventilator-Associated Pneumonia

(2011) T. P. Lodise et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetic and Pharmacodynamic Analysis of Linezolid and a Hematologic Side Effect, Thrombocytopenia, in Japanese Patients

(2011) Tomohiro Sasaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach

(2011) J.W. Mouton et al.   CLINICAL MICROBIOLOGY AND INFECTION

Efficacy, nephrotoxicity and ototoxicity of aminoglycosides, mathematically modelled for modelling-supported therapeutic drug monitoring

(2011) Sander Croes et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Tissue Penetration and Pharmacokinetics of Tigecycline in Diabetic Patients with Chronic Wound Infections Described by Using In Vivo Microdialysis

(2010) C. C. Bulik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interpreting population pharmacokinetic-pharmacodynamic analyses - a clinical viewpoint

(2010) Stephen B. Duffull et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Daptomycin Exposure and the Probability of Elevations in the Creatine Phosphokinase Level: Data from a Randomized Trial of Patients with Bacteremia and Endocarditis

(2010) Sujata M. Bhavnani et al.   CLINICAL INFECTIOUS DISEASES

Kinetics of Imipenem Distribution into the Peritoneal Fluid of Patients with Severe Peritonitis Studied by Microdialysis

(2010) Claire Dahyot-Fizelier et al.   CLINICAL PHARMACOKINETICS

Toxicodynamics of Itraconazole: Implications for Therapeutic Drug Monitoring

(2009) Jodi M. Lestner et al.   CLINICAL INFECTIOUS DISEASES

Relationship between Initial Vancomycin Concentration‐Time Profile and Nephrotoxicity among Hospitalized Patients

(2009) Thomas P. Lodise et al.   CLINICAL INFECTIOUS DISEASES

Antifungal pharmacokinetics and pharmacodynamics: bridging from the bench to bedside

(2009) W.W. Hope et al.   CLINICAL MICROBIOLOGY AND INFECTION

Augmented Renal Clearance

(2009) Andrew A. Udy et al.   CLINICAL PHARMACOKINETICS

Principles of antibacterial dosing in continuous renal replacement therapy

(2009) Gordon Choi et al.   CRITICAL CARE MEDICINE

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

In vitro pharmacodynamic models to determine the effect of antibacterial drugs

(2009) J. Gloede et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In Vivo Microdialysis Study of the Penetration of Daptomycin into Soft Tissues in Diabetic versus Healthy Volunteers

(2008) A. Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY