The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

Clinical applications of population pharmacokinetic models of antibiotics: Challenges and perspectives

(2018) Femke de Velde et al.   PHARMACOLOGICAL RESEARCH

How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients

(2018) Aaron J. Heffernan et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Association between increased mortality rate and antibiotic dose adjustment in intensive care unit patients with renal impairment

(2018) Marianne Silveira Camargo et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

(2017) T. Tängdén et al.   INTENSIVE CARE MEDICINE

Too much of a good thing: a retrospective study of β-lactam concentration–toxicity relationships

(2017) Sahand Imani et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

MIC-based dose adjustment: facts and fables

(2017) Johan W Mouton et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Simultaneous determination of nine β-lactam antibiotics in human plasma by an ultrafast hydrophilic-interaction chromatography–tandem mass spectrometry

(2017) Alan Abdulla et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study

(2016)   INTENSIVE CARE MEDICINE

Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis

(2016) Mohd H. Abdul-Aziz et al.   INTENSIVE CARE MEDICINE

Outcomes of Patients With Prolonged Intensive Care Unit Length of Stay After Cardiac Surgery

(2016) Pey-Jen Yu et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Time to Appropriate Antibiotic Therapy Is an Independent Determinant of Postinfection ICU and Hospital Lengths of Stay in Patients With Sepsis*

(2015) David Zhang et al.   CRITICAL CARE MEDICINE

Augmented renal clearance, low β-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort study

(2015) Angela Huttner et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Applying Pharmacokinetic/Pharmacodynamic Principles in Critically Ill Patients: Optimizing Efficacy and Reducing Resistance Development

(2015) Mohd Abdul-Aziz et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current  -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

(2014) J. A. Roberts et al.   CLINICAL INFECTIOUS DISEASES

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy

(2013) Barbara O.M. Claus et al.   JOURNAL OF CRITICAL CARE

The ciprofloxacin target AUC : MIC ratio is not reached in hospitalized patients with the recommended dosing regimens

(2012) Michiel Haeseker et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

An Antimicrobial Stewardship Program’s Impact with Rapid Polymerase Chain Reaction Methicillin‐ResistantStaphylococcus aureus/S. aureusBlood Culture Test in Patients withS. aureusBacteremia

(2010) Karri A. Bauer et al.   CLINICAL INFECTIOUS DISEASES

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

(2009) Jason A. Roberts et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ciprofloxacin use in critically ill patients: pharmacokinetic and pharmacodynamic approaches

(2008) Jean-Marie Conil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

(2008) Peggy S. McKinnon et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Ciprofloxacin pharmacokinetics in critically ill patients: A prospective cohort study

(2008) Arthur R.H. van Zanten et al.   JOURNAL OF CRITICAL CARE