Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation

Saga of Mcl-1: regulation from transcription to degradation

(2020) Viacheslav V. Senichkin et al.   CELL DEATH AND DIFFERENTIATION

Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy

(2019) Viacheslav V. Senichkin et al.   TRENDS IN CELL BIOLOGY

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

(2018) Michael Seiler et al.   NATURE MEDICINE

AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies

(2018) Sean Caenepeel et al.   Cancer Discovery

Apoptosis regulation by subcellular relocation of caspases

(2018) Evgeniia A. Prokhorova et al.   Scientific Reports

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

(2018) Adriana E. Tron et al.   Nature Communications

Widespread intra-dependencies in the removal of introns from human transcripts

(2017) Seong Won Kim et al.   NUCLEIC ACIDS RESEARCH

Involvement of autophagy in the outcome of mitotic catastrophe

(2017) Irina V. Sorokina et al.   Scientific Reports

MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks

(2016) Abid R. Mattoo et al.   MOLECULAR AND CELLULAR BIOLOGY

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex

(2016) Wataru Nakajima et al.   Oncotarget

Mcl-1 dynamics influence mitotic slippage and death in mitosis

(2016) Olivia Sloss et al.   Oncotarget

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1

(2015) M Larrayoz et al.   LEUKEMIA

Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis

(2014) B Wang et al.   CELL DEATH AND DIFFERENTIATION

Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma

(2014) T W Laetsch et al.   Cell Death & Disease

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

(2013) Mallikarjun Patil et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

(2012) Rhonda M. Perciavalle et al.   NATURE CELL BIOLOGY

Purification of Small Interfering RNA Using Nondenaturing Anion-Exchange Chromatography

(2011) Bernhard Noll et al.   Nucleic Acid Therapeutics

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

(2010) Sarwat Jamil et al.   CELL CYCLE

ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response

(2010) P Pawlikowska et al.   CELL DEATH AND DIFFERENTIATION

Mcl-1; the molecular regulation of protein function

(2010) Luke W. Thomas et al.   FEBS LETTERS

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

An Essential Role for MCL-1 in ATR-mediated CHK1 Phosphorylation

(2008) Sarwat Jamil et al.   MOLECULAR BIOLOGY OF THE CELL

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH