Review
Biochemistry & Molecular Biology
Yue Hu, Yumin Luo, Yangmin Zheng
Summary: Cerebrovascular disease is a prevalent and complex condition that poses a serious threat to human life and health. Current research has shown that oxidative stress and autophagy are important pathophysiological activities in cerebrovascular diseases, with some studies exploring their crosstalk. However, more detailed studies are needed to determine the specific mechanisms.
Review
Neurosciences
Jialin He, Jianyang Liu, Yan Huang, Xiangqi Tang, Han Xiao, Zhiping Hu
Summary: Ischemic stroke is a major cause of death worldwide, with limited treatment options focusing on restoring blood flow; autophagy plays a vital role in brain recovery post-stroke, while dysfunction can worsen cerebral injury; mesenchymal stem cells alleviate oxidative stress and inflammation, regulate autophagy imbalances, and show promise as a treatment for ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Miaomiao Liu, Xiaolin Liu, Maorong Zhou, Kai Sun
Summary: circRNA, a recently discovered class of endogenous non-coding RNA, acts as a molecular sponge to alter miRNA levels and is closely related to stroke. This summary focuses on the biological characteristics and expression of circRNA, as well as its impact on outcomes after ischemic stroke.
Article
Immunology
Tao Huang, Yang Gao, Yanwei Cao, Qinghai Wang, Zhen Dong
Summary: This study revealed the significant role of mmu_circ_0000943 in renal transplant by regulating miR-377-3p and Egr2, offering a novel insight into the treatment of AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Tao
Summary: Stroke is a major cause of death, with oxidative stress playing a key role. Celastrol has strong antioxidant properties, but its effect on oxidative reactions in cerebral ischemic-reperfusion injury (CIRI) is unclear. This study aimed to investigate the impact of celastrol on oxidative damage during CIRI and the underlying mechanisms. The findings revealed that celastrol reduced oxidative injury in CIRI by upregulating Nrf2. Celastrol directly bound to Nedd4, releasing Nrf2 in astrocytes, thus inhibiting Nrf2 degradation and reducing astrocytic ROS production. Celastrol also rescued neurons from damage and apoptosis by inhibiting oxidative stress and astrocyte activation.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Biotechnology & Applied Microbiology
Riccardo Cecchin, Zach Troyer, Ken Witwer, Kevin Morris
Summary: Extracellular vesicles (EVs) are considered as potential delivery vehicles for genetic therapeutics due to their non-immunogenic, biodegradable, and biocompatible properties. However, producing EVs at clinical scale remains challenging. Therefore, converting cells into EV factories using vector transduction technologies may be a solution to achieve stable and safe modulation of gene expression and function.
Article
Cell Biology
Mahshid Deldar Abad Paskeh, Ava Asadi, Sepideh Mirzaei, Mehrdad Hashemi, Maliheh Entezari, Rasoul Raesi, Kiavash Hushmandi, Ali Zarrabi, Yavuz Nuri Ertas, Amir Reza Aref, Saeed Samarghandian, Russel J. Reiter, Jun Ren
Summary: Ischemia is a pathological process that temporarily interrupts blood supply to an organ, leading to cellular and tissue damage. Ischemia/reperfusion (I/R) injury exacerbates oxidative stress-mediated damage. This article discusses the role of AMP-activated protein kinase (AMPK) in I/R and its signaling pathways and therapeutic applications.
CELLULAR SIGNALLING
(2022)
Article
Cardiac & Cardiovascular Systems
Yanfang Liu, Yufeng Li, Jiankun Zang, Tianyuan Zhang, Yaojie Li, Zefeng Tan, Dan Ma, Tao Zhang, Shiyong Wang, Yusheng Zhang, Lian Huang, Yousheng Wu, Xuanlin Su, Zean Weng, Die Deng, Chi Kwan Tsang, Anding Xu, Dan Lu
Summary: CircOGDH may serve as a potential biomarker for penumbra in AIS patients and play a role in ischemic neuronal damage. CircOGDH interacts with miR-5112, enhancing COL4A4 expression and exacerbating neuron damage. Knockdown of CircOGDH enhances neuronal cell viability under ischemic conditions. Additionally, CircOGDH is enriched in neuron-derived exosomes in peripheral blood.
CIRCULATION RESEARCH
(2022)
Article
Neurosciences
Xiaotang Ma, Jia Zhao, Suqing Li, Yan Wang, Jinhua Liu, Yumeng Shi, Jiehong Liu, Yanyu Chen, Yanfang Chen, Qunwen Pan
Summary: The study demonstrates that Rab27a regulates brain EXs secretion and functions, contributing to cerebral vascular protection from ischemic insult by preventing oxidative stress and apoptosis via down-regulating NOX2 and cleaved caspase-3 expression.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Amir Ajoolabady, Shuyi Wang, Guido Kroemer, Josef M. Penninger, Vladimir N. Uversky, Domenico Pratico, Nils Henninger, Russel J. Reiter, Askiel Bruno, Kaumudi Joshipura, Hamid Aslkhodapasandhokmabad, Daniel J. Klionsky, Jun Ren
Summary: Stroke is the second leading cause of death and a major cause of disability worldwide, with the majority of cases being ischemic. Recent research has highlighted the important role of autophagy in the pathogenesis of ischemic stroke. Autophagy serves as an adaptive mechanism for cell response to stroke, but excessive induction may be harmful.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
Bingyu Li, Wei Wang, Yanan Li, Su Wang, Hengjuan Liu, Zhongyuan Xia, Wenwei Gao, Bo Zhao
Summary: Activation of NCOA4-mediated ferritinophagy exacerbates early-stage CIRI and plays a crucial role in the progression of oxidative stress, autophagy, and apoptosis. The cGAS-STING pathway is implicated in regulating NCOA4-mediated ferritinophagy, and its inhibition ameliorates CIRI, attenuated by NCOA4 overexpression.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell Biology
Jin Yang, Lu-Lu Cao, Xi-Peng Wang, Wei Guo, Ruo-Bing Guo, Yu-Qin Sun, Teng-Fei Xue, Zhen-Yu Cai, Juan Ji, Hong Cheng, Xiu-Lan Sun
Summary: The study demonstrates the protective role of miR-98 in ischemic stroke by inhibiting microglial phagocytosis to reduce neuronal death. Neurons transfer miR-98 to microglia via EVs secretion to prevent phagocytosis of stressed-but-viable neurons.EVs derived miR-98 act as an intercellular signal mediating neurons and microglia communication during brain remodeling after ischemic stroke.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
He Li, Yin Luo, Peng Liu, Pei Liu, Weilong Hua, Yongxin Zhang, Lei Zhang, Zifu Li, Pengfei Xing, Yongwei Zhang, Bo Hong, Pengfei Yang, Jianmin Liu
Summary: The study demonstrated that cerebral ischemic preconditioning can ameliorate cerebral ischemia/reperfusion injury by releasing exosomes containing miR-451a.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Milad Ashrafizadeh, Saeed Samarghandian, Kiavash Hushmandi, Amirhossein Zabolian, Md Shahinozzaman, Hossein Saleki, Hossein Esmaeili, Mehdi Raei, Maliheh Entezari, Ali Zarrabi, Masoud Najafi
Summary: Quercetin administration is beneficial in ameliorating I/R injury by reducing ROS levels, inhibiting inflammation, and affecting molecular pathways such as TLR4/NF-kappa B, MAPK, etc. It can improve cell membrane integrity, inhibit apoptotic cell death, and modulate autophagy to decrease I/R injury. Nanoparticles have been used for delivery of quercetin, enhancing its efficacy in alleviating I/R injury, as confirmed by clinical trials.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
