SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

(2019) Haijiao Zhang et al.   Nature Communications

Gilteritinib: First Global Approval

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Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

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Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2 - and TET2 -Mutant Acute Myeloid Leukemia

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DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

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DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

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Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

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DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation

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