The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

(2020) Vienna E. Brunt et al.   HYPERTENSION

Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice

(2019) Vienna E. Brunt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Physical Activity, Cognition, and Brain Outcomes

(2019) KIRK I. ERICKSON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats

(2019) Fanqing Meng et al.   BEHAVIOURAL BRAIN RESEARCH

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A

(2019) Liang Zhao et al.   NEUROCHEMICAL RESEARCH

Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study

(2019) Chen Zhu et al.   NEUROLOGICAL SCIENCES

Astrocyte senescence contributes to cognitive decline

(2019) Tamas Csipo et al.   GeroScience

TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes

(2019) Thomas J. LaRocca et al.   NEUROBIOLOGY OF DISEASE

Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions

(2018) Sophie Miquel et al.   AGEING RESEARCH REVIEWS

Trimethylamine-N -oxide promotes brain aging and cognitive impairment in mice

(2018) Dang Li et al.   AGING CELL

Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results

(2018) Hector M. González et al.   Alzheimers & Dementia

Innate Immunity and Neurodegeneration

(2018) Larisa I. Labzin et al.   Annual Review of Medicine

Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease

(2018) Tiejun Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

Midlife cardiovascular fitness and dementia

(2018) Helena Hörder et al.   NEUROLOGY

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

(2017) Svetlana Di Benedetto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid

(2017) Daniele Del Rio et al.   Nutrients

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

(2017) Tiejun Li et al.   Frontiers in Physiology

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

(2016) Rong Xu et al.   BMC Systems Biology

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents

(2015) Ben Grayson et al.   BEHAVIOURAL BRAIN RESEARCH

Short-term high-fat diet increases postprandial trimethylamine- N -oxide in humans

(2015) Nabil E. Boutagy et al.   NUTRITION RESEARCH

Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet

(2015) Nabil E. Boutagy et al.   Obesity

Battery of behavioral tests in mice that models age-associated changes in human motor function

(2014) Jamie N. Justice et al.   AGE

Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry

(2014) Zeneng Wang et al.   ANALYTICAL BIOCHEMISTRY

Protein Kinase R and the Inflammasome

(2014) Howard C.H. Yim et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiorespiratory fitness and cognitive function in middle age: The CARDIA Study

(2014) N. Zhu et al.   NEUROLOGY

Normal Cognitive Aging

(2013) Caroline N. Harada et al.   CLINICS IN GERIATRIC MEDICINE

The autophagy enhancer spermidine reverses arterial aging

(2013) Thomas J. LaRocca et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Physiology: Inflammation links ageing to the brain

(2013) Dana Gabuzda et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Norming plans for the NIH Toolbox

(2013) J. L. Beaumont et al.   NEUROLOGY

Cognition assessment using the NIH Toolbox

(2013) S. Weintraub et al.   NEUROLOGY

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactive astrocytes secrete lcn2 to promote neuron death

(2013) F. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin ameliorates arterial dysfunction and oxidative stress with aging

(2012) Bradley S. Fleenor et al.   EXPERIMENTAL GERONTOLOGY

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Changes in behaviors of male C57BL/6J mice across adult life span and effects of dietary restriction

(2011) Andreas Fahlström et al.   AGE

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging

(2011) Amy L. Sindler et al.   AGING CELL

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline

(2011) S. Debette et al.   NEUROLOGY

Cognitive dysfunction with aging and the role of inflammation

(2011) Arthur A. Simen et al.   Therapeutic Advances in Chronic Disease

Neuroinflammation and Cognitive Aging

(2010) Raymond L. Ownby   Current Psychiatry Reports