☆ 4.4 Article

Handgrip strength-a risk indicator for future fractures in the general population: findings from a prospective study and meta-analysis of 19 prospective cohort studies

GEROSCIENCE (2021)

Journal

GEROSCIENCE

Volume 43, Issue 2, Pages 869-880

Publisher

SPRINGER

DOI: 10.1007/s11357-020-00251-8

Keywords

Handgrip strength; Fracture; Cohort study; Meta-analysis

Funding

Finnish Foundation for Cardiovascular Research, Helsinki, Finland
NIHR Biomedical Research Centre at the University Hospitals Bristol
Weston NHS Foundation Trust
University of Bristol [BRC-1215-20011]

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Abstract

The study suggests that individuals with stronger handgrip are at reduced risk of fractures in the future, but the association between handgrip and fracture risk is only modest.

Evolving debate suggests that handgrip strength, a measure of muscular strength, might be associated with the risk of fractures; however, the evidence is conflicting. We aimed to assess the association of handgrip strength with the risk of fracture in the general population. Handgrip strength, measured using a dynamometer, was assessed at baseline in a population-based sample of 853 men and women aged 61-73 years in the Kuopio Ischemic Heart Disease prospective cohort. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for incident fractures. Incident fractures (hip, humeral, or wrist) (n= 159) occurred during a median follow-up of 16.7 years. Comparing extreme tertiles of handgrip strength, the age- and sex-adjusted hazard ratio (95% CI) for fractures was 0.80 (0.55-1.18). The association remained similar on further adjustment for other potential confounders: HR (95% CI) of 0.82 (0.55-1.21). In a meta-analysis of 19 population-based prospective cohort studies (including the current study) comprising 220,757 participants and 9199 fractures (including 1302 hip fractures), the fully adjusted relative risk (RR) (95% confidence interval, CI) for incident fractures was 0.70 (0.61-0.80) comparing the top versus bottom thirds of handgrip strength. The association remained significant after trim-and-fill correction for publication bias. The corresponding RR (95% CI) for hip fractures (9 studies) was 0.61 (0.54-0.70). Handgrip was only modestly associated with fracture risk in the primary analysis, which may be driven by the low event rate. Pooled prospective cohort evidence suggests that elevated handgrip strength is associated with reduced future fracture risk.

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Association Between Handgrip Strength and Type 2 Diabetes: A Prospective Cohort Study and Systematic Review With Meta-analysis

Hongmei Wu, Yeqing Gu, Xuena Wang, Ge Meng, Sabina Rayamajhi, Amrish Thapa, Qing Zhang, Li Liu, Shunming Zhang, Tingjing Zhang, Zhixia Cao, Jun Dong, Xiaoxi Zheng, Xu Zhang, Xinrong Dong, Xing Wang, Shaomei Sun, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Kaijun Niu

Summary: In this study, relative handgrip strength was found to be inversely associated with incident type 2 diabetes, while absolute handgrip strength showed no significant association. Meta-analysis results further supported the superiority of relative handgrip strength in predicting T2DM.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2023)