MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer
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Title
MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-09-29
DOI
10.3389/fonc.2020.571601
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Note: Only part of the references are listed.- MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells
- (2018) Yi Na Yoon et al. BMC CANCER
- MASTL overexpression promotes chromosome instability and metastasis in breast cancer
- (2018) Samuel Rogers et al. ONCOGENE
- Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
- (2018) Lingdi Zhang et al. Nature Communications
- Identification of new inhibitors against human Great wall kinase using in silico approaches
- (2018) Ummi Ammarah et al. Scientific Reports
- MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling
- (2018) Srijayaprakash Babu Uppada et al. Molecular Cancer
- Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells
- (2018) Elena Cetti et al. CANCER LETTERS
- Breast cancer stem cells in HER2-negative breast cancer cells contribute to HER2-mediated radioresistance and molecular subtype conversion: clinical implications for serum HER2 in recurrent HER2-negative breast cancer
- (2017) Yun Gyoung Kim et al. Oncotarget
- A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct
- (2016) Cory A. Ocasio et al. Oncotarget
- MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation
- (2016) Po Yee Wong et al. Scientific Reports
- Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC
- (2015) R. Nagel et al. MOLECULAR CANCER THERAPEUTICS
- Targeting Mitosis in Cancer: Emerging Strategies
- (2015) Carmen Dominguez-Brauer et al. MOLECULAR CELL
- Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening
- (2015) Maria Chiara Anania et al. Oncotarget
- Greatwall promotes cell transformation by hyperactivating AKT in human malignancies
- (2015) Jorge Vera et al. eLife
- Mastl kinase, a promising therapeutic target, promotes cancer recurrence
- (2015) Ling Wang et al. Oncotarget
- Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances
- (2014) Evanthia Lionta et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Role of Greatwall kinase in release of mouse oocytes from diplotene arrest
- (2014) Xiangyu Zhao et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- Greatwall Kinase Is Required for Meiotic Maturation in Porcine Oocytes1
- (2013) Ying-Hua Li et al. BIOLOGY OF REPRODUCTION
- CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1
- (2013) J.-S. Kim et al. CANCER RESEARCH
- Docking Challenge: Protein Sampling and Molecular Docking Performance
- (2013) Khaled M. Elokely et al. Journal of Chemical Information and Modeling
- Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity
- (2012) Appalaraju Jaggupilli et al. Clinical & Developmental Immunology
- AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
- (2012) T. A. Yap et al. CLINICAL CANCER RESEARCH
- Bypassing the Greatwall-Endosulfine Pathway: Plasticity of a Pivotal Cell-Cycle Regulatory Module in Drosophila melanogaster and Caenorhabditis elegans
- (2012) M.-Y. Kim et al. GENETICS
- Mitosis-targeted anti-cancer therapies: where they stand
- (2012) K-S Chan et al. Cell Death & Disease
- Greatwall and Polo-like Kinase 1 Coordinate to Promote Checkpoint Recovery
- (2011) Aimin Peng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Greatwall kinase during Xenopus oocyte maturation
- (2011) Tomomi M. Yamamoto et al. MOLECULAR BIOLOGY OF THE CELL
- Mitotic catastrophe: a mechanism for avoiding genomic instability
- (2011) Ilio Vitale et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A novel role for Greatwall kinase in recovery from DNA damage
- (2010) Aimin Peng et al. CELL CYCLE
- Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
- (2010) Andrew Burgess et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production
- (2010) Jae-Sung Kim et al. PROTEOMICS
- The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A
- (2010) A. Gharbi-Ayachi et al. SCIENCE
- Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis
- (2010) S. Mochida et al. SCIENCE
- Greatwall maintains mitosis through regulation of PP2A
- (2009) Suzanne Vigneron et al. EMBO JOURNAL
- The nuts and bolts of AGC protein kinases
- (2009) Laura R. Pearce et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Multiple pathways regulated by the tumor suppressor PP2A in transformation
- (2008) Jukka Westermarck et al. TRENDS IN MOLECULAR MEDICINE
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