Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

(2020) Xinyi Wang et al.   Molecular Oncology

Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

(2019) Wanfu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PKM2‐regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF‐β1‐induced EMT

(2019) Rong Ma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nuclear EGFR-PKM2 axis induces cancer stem cell-like characteristics in irradiation-resistant cells

(2018) Ying Shi et al.   CANCER LETTERS

Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

(2018) Yi-Chieh Yang et al.   CANCER LETTERS

Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells

(2018) Zhifen Zhou et al.   CANCER RESEARCH

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma

(2018) Xiaoping Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

(2018) Ming-Chuan Hsu et al.   Molecular Cancer

Metastatic Prostate Cancer

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

(2018) Virginia Murillo-Garzón et al.   Nature Communications

Silibinin attenuates TGF‑β1‑induced migration and invasion via EMT suppression and is associated with COX‑2 downregulation in bladder transitional cell carcinoma

(2018) Feng Li et al.   ONCOLOGY REPORTS

Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2

(2018) Fumie Tanaka et al.   Oncotarget

Cancer Statistics for Hispanics/Latinos, 2018

(2018) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair

(2018) Steven T. Sizemore et al.   CELL RESEARCH

Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial–mesenchymal transition via Wnt/β-catenin signaling

(2018) Yanzhu Lin et al.   Cancer Management and Research

Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer

(2017) Debashree Basudhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect

(2017) Yang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β1 (TGF-β1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells

(2017) Ke-yan Cheng et al.   MEDICAL SCIENCE MONITOR

Specific c-Jun target genes in malignant melanoma

(2016) Patrick Schummer et al.   CANCER BIOLOGY & THERAPY

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

(2016) Abhishek Bhardwaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy

(2016) Antoine Buetti-Dinh et al.   PLoS One

The Role of Pyruvate Kinase M2 in Cancer Metabolism

(2015) Vivian M. Liu et al.   BRAIN PATHOLOGY

Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-κB- and MAPK-ERK1/2-mediated COX-2 expression

(2015) Chun-Kuang Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pyruvate kinase M2 at a glance

(2015) W. Yang et al.   JOURNAL OF CELL SCIENCE

TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma

(2014) Z Chen et al.   ONCOGENE

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition

(2014) A. Hamabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AP-1/c-Jun transcription factors: Regulation and function in malignant melanoma

(2013) Melanie Kappelmann et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

EGF-like Growth Factors Induce COX-2–Derived PGE2 Production Through ERK1/2 in Human Granulosa Cells

(2013) Lanlan Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of cyclooxygenase-2 in gastric cancer development and progression

(2013) Jian Cheng   WORLD JOURNAL OF GASTROENTEROLOGY

PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF- B- and HDAC1-mediated expression and activation of uPA

(2012) Z. Zou et al.   JOURNAL OF CELL SCIENCE

MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression

(2012) M Kappelmann et al.   ONCOGENE

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma

(2011) Barbara Spangler et al.   INTERNATIONAL JOURNAL OF CANCER

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

(2010) Sonja I Buschow et al.   IMMUNOLOGY AND CELL BIOLOGY

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE