Sexual Dimorphism in Osteoclasts

Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair

(2020) Sanja Novak et al.   JOURNAL OF IMMUNOLOGY

Osteocyte-Mediated Translation of Mechanical Stimuli to Cellular Signaling and Its Role in Bone and Non-bone-Related Clinical Complications

(2020) Yongyong Yan et al.   Current Osteoporosis Reports

Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1

(2020) Maria-Bernadette Madel et al.   eLife

Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors

(2020) Ha-Neui Kim et al.   Scientific Reports

Conditional Knockout of PKC-δ in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function

(2020) Shangfu Li et al.   Frontiers in Cell and Developmental Biology

Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions

(2019) Maria-Bernadette Madel et al.   Frontiers in Immunology

Hormone‐Independent Sexual Dimorphism in the Regulation of Bone Resorption by Krox20

(2019) Elias Sabag et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3

(2019) Bongjin Shin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MAP kinase phosphatase-1, a gatekeeper of the acute innate immune response

(2019) Sean G. Kirk et al.   LIFE SCIENCES

Sexual Dimorphism in Immunity to Oral Bacterial Diseases: Intersection of Neutrophil and Osteoclast Pathobiology

(2018) M.S. Valerio et al.   JOURNAL OF DENTAL RESEARCH

LYN, a key mediator in estrogen-dependent suppression of osteoclast differentiation, survival, and function

(2018) Shubhangi Gavali et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice

(2016) Anja C. Bloom et al.   BONE

Runx1Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or Phagocytic Cells in Both Males and Females

(2016) David N. Paglia et al.   ENDOCRINOLOGY

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

(2016) Jau-Yi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Sex-based differential regulation of bacterial-induced bone resorption

(2016) M. S. Valerio et al.   JOURNAL OF PERIODONTAL RESEARCH

Androgen receptors and experimental bone loss — an in vivo and in vitro study

(2015) Joao Paulo Steffens et al.   BONE

Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice

(2015) Loai Alsofi et al.   CALCIFIED TISSUE INTERNATIONAL

Caveolin-1 Regulates Osteoclastogenesis and Bone Metabolism in a Sex-dependent Manner

(2015) Yong Deok Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERα Signaling in Osteoblasts and Osteoclasts

(2015) Serra Ucer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts

(2015) Mieke Sinnesael et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk

(2013) B.C.J. van der Eerden et al.   BONE

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery

(2012) Christian E Jacome-Galarza et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sex-specific effects of estrogen and androgen on gene expression in human monocyte-derived osteoclasts

(2011) Jun Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fas receptor is required for estrogen deficiency-induced bone loss in mice

(2010) Natasa Kovacic et al.   LABORATORY INVESTIGATION

Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen receptor-α with BCAR1 and Traf6

(2009) Lisa J. Robinson et al.   EXPERIMENTAL CELL RESEARCH

Immunohistochemical detection of estrogen receptor β in alveolar bone cells of estradiol-treated female rats: possible direct action of estrogen on osteoclast life span

(2009) Mady Cruzoé-Souza et al.   JOURNAL OF ANATOMY

Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival

(2008) Susan A Krum et al.   EMBO JOURNAL

Osteoimmunology: Interactions of the Bone and Immune System

(2008) Joseph Lorenzo et al.   ENDOCRINE REVIEWS

Osteoporosis: An Age-Related and Gender-Specific Disease – A Mini-Review

(2008) Peter Pietschmann et al.   GERONTOLOGY