N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours

Metagenomic characterization of lysine acetyltransferases in human cancer and their association with clinicopathologic features

(2020) Yuanyuan Jiang et al.   CANCER SCIENCE

Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

(2020) Pei-Pei Kung et al.   ACS Medicinal Chemistry Letters

Mechanism of actin N-terminal acetylation

(2020) Grzegorz Rebowski et al.   Science Advances

Discovering and validating cancer genetic dependencies: approaches and pitfalls

(2020) Ann Lin et al.   NATURE REVIEWS GENETICS

Histone N-alpha terminal modifications: genome regulation at the tip of the tail

(2020) Christina Demetriadou et al.   Epigenetics & Chromatin

NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression

(2019) Christina Demetriadou et al.   Cell Death & Disease

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

(2019) Henriette Aksnes et al.   MOLECULAR CELL

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies

(2018) Hanyin Cheng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NAT6 acetylates the N-terminus of different forms of actin

(2018) Elsa Wiame et al.   FEBS Journal

NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility

(2018) Adrian Drazic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

(2018) Dafni Anastasiadi et al.   Epigenetics & Chromatin

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

(2017) Junyi Ju et al.   Nature Communications

NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma

(2017) Leire Neri et al.   Oncotarget

A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin

(2016) Anne M. Molloy et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of Nat4 and its associated histone H4 N‐terminal acetylation mediates calorie restriction‐induced longevity

(2016) Diego Molina‐Serrano et al.   EMBO REPORTS

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases

(2016) Henriette Aksnes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms

(2016) Om Singh Rathore et al.   Scientific Reports

Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway

(2015) Demetria Pavlou et al.   APOPTOSIS

Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

(2015) Awais A. Mughal et al.   Molecular Cancer

Targeted exploration and analysis of large cross-platform human transcriptomic compendia

(2015) Qian Zhu et al.   NATURE METHODS

An Organellar Nα-Acetyltransferase, Naa60, Acetylates Cytosolic N Termini of Transmembrane Proteins and Maintains Golgi Integrity

(2015) Henriette Aksnes et al.   Cell Reports

Design, Synthesis, and Kinetic Characterization of Protein N-Terminal Acetyltransferase Inhibitors

(2013) Håvard Foyn et al.   ACS Chemical Biology

Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog

(2013) Glen Liszczak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-alpha-terminal Acetylation of Histone H4 Regulates Arginine Methylation and Ribosomal DNA Silencing

(2013) Vassia Schiza et al.   PLoS Genetics

Expression of humanNAA11(ARD1B) gene is tissue-specific and is regulated by DNA methylation

(2012) Alan L.Y. Pang et al.   Epigenetics

Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis

(2012) Yang Liu et al.   JOURNAL OF LIPID RESEARCH

Protein N-terminal acetyltransferases in cancer

(2012) T V Kalvik et al.   ONCOGENE

Protein N-terminal acetyltransferases: when the start matters

(2012) Kristian K. Starheim et al.   TRENDS IN BIOCHEMICAL SCIENCES

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

The Human N-Alpha-Acetyltransferase 40 (hNaa40p/hNatD) Is Conserved from Yeast and N-Terminally Acetylates Histones H2A and H4

(2011) Kristine Hole et al.   PLoS One

A novel human NatA Nα-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1)

(2009) Thomas Arnesen et al.   BMC BIOCHEMISTRY

DNA hypomethylation in cancer cells

(2009) Melanie Ehrlich   Epigenomics