Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined Groups

Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Neuroendocrine Tumors: Results From the Phase 2 KEYNOTE-158 Study

(2020) Jonathan R Strosberg et al.   CLINICAL CANCER RESEARCH

ARID1A alterations function as a biomarker for longer progression-free survival after anti-PD-1/PD-L1 immunotherapy

(2020) Ryosuke Okamura et al.   Journal for ImmunoTherapy of Cancer

Efficacy of immune check-point inhibitors (ICPi) in large cell neuroendocrine tumors of lung (LCNEC)

(2020) Shira Sherman et al.   LUNG CANCER

Transcriptomic data helps refining classification of pulmonary carcinoid tumors with increased mitotic counts

(2020) Olga Sazonova et al.   MODERN PATHOLOGY

Ki-67 index of 55% distinguishes two groups of bronchopulmonary pure and composite large cell neuroendocrine carcinomas with distinct prognosis

(2020) Massimo Milione et al.   NEUROENDOCRINOLOGY

Immune Checkpoint Inhibitors in Thoracic Malignancies: Review of the Existing Evidence by an IASLC Expert Panel and Recommendations

(2020) Jordi Remon et al.   Journal of Thoracic Oncology

Gene expression profiling of lung atypical carcinoids and large cell neuroendocrine carcinomas identifies three transcriptomic subtypes with specific genomic alterations

(2019) Michele Simbolo et al.   Journal of Thoracic Oncology

Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids

(2019) Saurabh V. Laddha et al.   CANCER RESEARCH

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

(2019) N. Alcala et al.   Nature Communications

Pulmonary carcinoid tumours: incidence, histology, and surgical outcome. A population-based study

(2019) Astridur Petursdottir et al.   General Thoracic and Cardiovascular Surgery

Pathways Impacted by Genomic Alterations in Pulmonary Carcinoid Tumors

(2018) Michael K. Asiedu et al.   CLINICAL CANCER RESEARCH

Current and future therapeutic approaches for the treatment of small cell lung cancer

(2018) Antonio Rossi et al.   Expert Review of Anticancer Therapy

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade

(2018) Jianfeng Shen et al.   NATURE MEDICINE

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

(2018) Julie George et al.   Nature Communications

A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal

(2018) Guido Rindi et al.   MODERN PATHOLOGY

1308OActivity & safety of spartalizumab (PDR001) in patients (pts) with advanced neuroendocrine tumors (NET) of pancreatic (Pan), gastrointestinal (GI), or thoracic (T) origin, & gastroenteropancreatic neuroendocrine carcinoma (GEP NEC) who have progressed on prior treatment (Tx)

(2018) J C Yao et al.   ANNALS OF ONCOLOGY

Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine

(2017) Laetitia Nebot-Bral et al.   EUROPEAN JOURNAL OF CANCER

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification

(2017) Anna Karlsson et al.   Journal of Thoracic Oncology

Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease

(2017) Andrew E. Hendifar et al.   Journal of Thoracic Oncology

Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas

(2017) Bryan Oronsky et al.   NEOPLASIA

Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States

(2017) Arvind Dasari et al.   JAMA Oncology

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung

(2016) Tomohiro Miyoshi et al.   CLINICAL CANCER RESEARCH

Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets

(2016) N. Rekhtman et al.   CLINICAL CANCER RESEARCH

Diagnosis and management of typical and atypical lung carcinoids

(2016) Sara Pusceddu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Lung neuroendocrine tumours: deep sequencing of the four World Health Organization histotypes reveals chromatin-remodelling genes as major players and a prognostic role forTERT,RB1,MEN1andKMT2D

(2016) Michele Simbolo et al.   JOURNAL OF PATHOLOGY

Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression

(2016) Eric Polley et al.   JNCI-Journal of the National Cancer Institute

Treating cancer with selective CDK4/6 inhibitors

(2016) Ben O'Leary et al.   Nature Reviews Clinical Oncology

Treatment of lung large cell neuroendocrine carcinoma

(2016) Giuseppe Lo Russo et al.   TUMOR BIOLOGY

Peptide receptor radionuclide therapy: focus on bronchial neuroendocrine tumors

(2016) Giuseppe Lo Russo et al.   TUMOR BIOLOGY

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

(2016) Chris T. Williamson et al.   Nature Communications

Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression

(2016) Eric Polley et al.   JNCI-Journal of the National Cancer Institute

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids

(2015) M. E. Caplin et al.   ANNALS OF ONCOLOGY

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group

(2015) Claudia Vollbrecht et al.   BRITISH JOURNAL OF CANCER

Clinical features of large cell neuroendocrine carcinoma: a population-based overview

(2015) Jules L. Derks et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy

(2015) Morena Fasano et al.   Journal of Thoracic Oncology

Driver Gene Mutations of Non-Small-Cell Lung Cancer are Rare in Primary Carcinoids of the Lung: NGS Study by Ion Torrent

(2015) Gemma Armengol et al.   LUNG

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

(2015) Benjamin G Bitler et al.   NATURE MEDICINE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer

(2015) Anna Karlsson et al.   Oncotarget

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition

(2015) Eleftherios P. Samartzis et al.   Oncotarget

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

(2014) Lynnette Fernandez-Cuesta et al.   Nature Communications

MEN1Gene Mutation and Reduced Expression Are Associated With Poor Prognosis in Pulmonary Carcinoids

(2013) Dorian R. A. Swarts et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Molecular and cellular biology of neuroendocrine lung tumors: Evidence for separate biological entities

(2012) Dorian R.A. Swarts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?

(2012) Jennifer N. Wu et al.   Cancer Discovery

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Small-cell lung cancer

(2011) Jan P van Meerbeeck et al.   LANCET

Advances in neuroendocrine lung tumors

(2010) W. D. Travis   ANNALS OF ONCOLOGY

Bronchopulmonary neuroendocrine tumors

(2008) Bjorn I. Gustafsson et al.   CANCER