Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells

ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses

(2019) Iman Azimi et al.   Cancers

Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership

(2019) Marta Peretti et al.   Scientific Reports

STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and ICRAC

(2019) Esther Lopez et al.   JOURNAL OF CELL SCIENCE

TRPC3 Regulates the Proliferation and Apoptosis Resistance of Triple Negative Breast Cancer Cells through the TRPC3/RASA4/MAPK Pathway

(2019) Wang et al.   Cancers

Store-independent Orai1-mediated Ca2+ entry and cancer

(2019) C. Cantonero et al.   CELL CALCIUM

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

(2019) Xuexin Zhang et al.   Nature Communications

High salt induces P-glycoprotein mediated treatment resistance in breast cancer cells through store operated calcium influx

(2018) Duaa Babaer et al.   Oncotarget

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure

(2018) Isaac Jardin et al.   Cancers

Store-Operated Ca2+ Entry in Breast Cancer Cells: Remodeling and Functional Role

(2018) Isaac Jardin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interplay between Epigenetics, Expression of Estrogen Receptor- α, HER2/ERBB2 and Sensitivity of Triple Negative Breast Cancer Cells to Hormonal Therapy

(2018) Wafaa S Ramadan et al.   Cancers

sp2 -Iminosugar α-glucosidase inhibitor 1-C -octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways

(2017) Nahla Gueder et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway

(2017) Mehdi Badaoui et al.   Oncotarget

Filamin A Modulates Store-Operated Ca 2+ Entry by Regulating STIM1 (Stromal Interaction Molecule 1)–Orai1 Association in Human Platelets

(2017) Jose J. Lopez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner

(2016) L. Albarran et al.   BIOCHEMICAL JOURNAL

The Orai1 Store-operated Calcium Channel Functions as a Hexamer

(2016) Xiangyu Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phemindole, a Synthetic Di-indole Derivative Maneuvers the Store Operated Calcium Entry (SOCE) to Induce Potent Anti-Carcinogenic Activity in Human Triple Negative Breast Cancer Cells

(2016) Supriya Chakraborty et al.   Frontiers in Pharmacology

Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx

(2015) Joseph L. Dynes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple types of calcium channels arising from alternative translation initiation of theOrai1message

(2015) Pooja N. Desai et al.   Science Signaling

Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes

(2015) Y. Wang et al.   STEM CELLS

Multiple types of calcium channels arising from alternative translation initiation of theOrai1message

(2015) Pooja N. Desai et al.   Science Signaling

Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma

(2014) Ji-Hee Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function

(2013) Archana Jha et al.   JOURNAL OF CELL BIOLOGY

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo

(2012) V. M. Golubovskaya et al.   CARCINOGENESIS

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

(2012) Raz Palty et al.   CELL

Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

(2012) Baotran Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities

(2012) M. Fukushima et al.   JOURNAL OF CELL SCIENCE

Human ether à-gogo K+ channel 1 (hEag1) regulates MDA-MB-231 breast cancer cell migration through Orai1-dependent calcium entry

(2012) Mehdi Hammadi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

(2012) D. Willoughby et al.   Science Signaling

STIM1 and STIM2 Are Located in the Acidic Ca2+Stores and Associates with Orai1 upon Depletion of the Acidic Stores in Human Platelets

(2011) Hanene Zbidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

(2011) D. McAndrew et al.   MOLECULAR CANCER THERAPEUTICS

Improved Elution Conditions for Native Co-Immunoprecipitation

(2011) Robin Antrobus et al.   PLoS One

A Novel Native Store-operated Calcium Channel Encoded by Orai3

(2010) Rajender K. Motiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C-induced Phosphorylation of Orai1 Regulates the Intracellular Ca2+Level via the Store-operated Ca2+Channel

(2010) Takumi Kawasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

FAK/src-Family Dependent Activation of the Ste20-Like Kinase SLK Is Required for Microtubule-Dependent Focal Adhesion Turnover and Cell Migration

(2008) Simona Wagner et al.   PLoS One