Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions

NK Cells in the Human Lungs

(2019) Baptiste Hervier et al.   Frontiers in Immunology

Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation

(2019) Leah Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells

(2019) Nicole Marquardt et al.   Nature Communications

The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy

(2019) Haoyu Sun et al.   Frontiers in Immunology

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

(2019) Shi Yong Neo et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired Tumor-infiltrating T Cells in Patients with COPD Impacts Lung Cancer Response to PD-1 Blockade

(2018) Jérôme Biton et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression

(2018) Jingjing Cong et al.   Cell Metabolism

CTLA-4 regulates human Natural Killer cell effector functions

(2018) Vassilios Lougaris et al.   CLINICAL IMMUNOLOGY

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

(2018) Qing Zhang et al.   NATURE IMMUNOLOGY

Immune Prophets of Lung Cancer: The Prognostic and Predictive Landscape of Cellular and Molecular Immune Markers

(2018) Ivana Catacchio et al.   Translational Oncology

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

(2018) Pascale André et al.   CELL

Circulating NKp46+ Natural Killer cells have a potential regulatory property and predict distinct survival in Non-Small Cell Lung Cancer

(2018) Emilie Picard et al.   OncoImmunology

A distinct innate lymphoid cell population regulates tumor-associated T cells

(2017) Sarah Q Crome et al.   NATURE MEDICINE

Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity

(2016) Christine Pasero et al.   CANCER RESEARCH

Liver-infiltrating CD11b−CD27− NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression

(2016) Qiong-Fang Zhang et al.   Cellular & Molecular Immunology

NK Cells Restrain Spontaneous Antitumor CD8+T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells

(2016) Ximena L. Raffo Iraolagoitia et al.   JOURNAL OF IMMUNOLOGY

CIS is a potent checkpoint in NK cell–mediated tumor immunity

(2016) Rebecca B Delconte et al.   NATURE IMMUNOLOGY

CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver

(2016) Kerstin A. Stegmann et al.   Scientific Reports

CD56brightCD16−NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+T Cell Proliferation

(2015) Fabio Morandi et al.   JOURNAL OF IMMUNOLOGY

Confusing signals: Recent progress in CTLA-4 biology

(2015) Lucy S.K. Walker et al.   TRENDS IN IMMUNOLOGY

NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade

(2015) Frederick J Kohlhapp et al.   Journal for ImmunoTherapy of Cancer

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting the alternatively spliced soluble isoform of CTLA-4: prospects for immunotherapy?

(2014) Frank J Ward et al.   Immunotherapy

CTLA-4 Is Expressed by Activated Mouse NK Cells and Inhibits NK Cell IFN-  Production in Response to Mature Dendritic Cells

(2014) A. Stojanovic et al.   JOURNAL OF IMMUNOLOGY

Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors

(2013) S. Rusakiewicz et al.   CANCER RESEARCH

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

(2013) J. Goc et al.   CANCER RESEARCH

Neuroblastoma-Derived TGF- 1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells

(2013) R. Castriconi et al.   JOURNAL OF IMMUNOLOGY

Lung Tumor Microenvironment Induces Specific Gene Expression Signature in Intratumoral NK Cells

(2013) Mélanie Gillard-Bocquet et al.   Frontiers in Immunology

Abstract 2757: TAS-106, a newly synthesized RNA polymerase inhibitor, combined with cisplatin exhibits potent synergistic growth-inhibitory effect via Vaults dysfunction

(2012) Hiroto Fukushima et al.   CANCER RESEARCH

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

(2011) S. Platonova et al.   CANCER RESEARCH

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

(2011) Emilie Mamessier et al.   JOURNAL OF CLINICAL INVESTIGATION

Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis

(2011) W. Jiang et al.   JOURNAL OF IMMUNOLOGY

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Maturation of mouse NK cells is a 4-stage developmental program

(2009) L. Chiossone et al.   BLOOD

Regulatory Natural Killer Cells: New Players in the IL-10 Anti-Inflammatory Response

(2009) Eric Vivier et al.   Cell Host & Microbe

Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56brightCD16− cells and display an impaired capability to kill tumor cells

(2008) Paolo Carrega et al.   CANCER

Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid Structures

(2008) Marie-Caroline Dieu-Nosjean et al.   JOURNAL OF CLINICAL ONCOLOGY