The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy
Published 2019 View Full Article
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Title
The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-10-17
DOI
10.3389/fimmu.2019.02354
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Note: Only part of the references are listed.- Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer
- (2019) Niclas C. Blessin et al. DISEASE MARKERS
- The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy
- (2019) Fernando Souza-Fonseca-Guimaraes et al. TRENDS IN IMMUNOLOGY
- How Natural Killer Cell Receptors Stick to Cell–Cell Adhesion Proteins
- (2019) Sharanbasappa S. Karade et al. STRUCTURE
- A Variant of a Killer Cell Immunoglobulin-like Receptor is Associated with Resistance to PD-1 Blockade in Lung Cancer
- (2019) Marcel P Trefny et al. CLINICAL CANCER RESEARCH
- Expression analysis and significance of PD-1, LAG-3 and TIM-3 in human non-small cell lung cancer using spatially-resolved and multiparametric single-cell analysis.
- (2019) Ila J Datar et al. CLINICAL CANCER RESEARCH
- NK‐ and T‐cell subsets in malignant mesothelioma patients: Baseline pattern and changes in the context of anti‐CTLA‐4 therapy
- (2019) Rosa Sottile et al. INTERNATIONAL JOURNAL OF CANCER
- Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells
- (2019) Takahiro Kamiya et al. JOURNAL OF CLINICAL INVESTIGATION
- Setting traps for NKG2A gives NK cell immunotherapy a fighting chance
- (2019) Frank Cichocki et al. JOURNAL OF CLINICAL INVESTIGATION
- TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer
- (2019) Yujia Zheng et al. Journal of Translational Medicine
- Imbalance of Genes Encoding Natural Killer Immunoglobulin-like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
- (2019) Martin Cornillet et al. GASTROENTEROLOGY
- Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function
- (2019) Clara Degos et al. Frontiers in Immunology
- Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells
- (2019) Laia Gorchs et al. Frontiers in Immunology
- IPH4102, a first-in-class anti-KIR3DL2 monoclonal antibody, in patients with relapsed or refractory cutaneous T-cell lymphoma: an international, first-in-human, open-label, phase 1 trial
- (2019) Martine Bagot et al. LANCET ONCOLOGY
- First report of overall survival for ipilimumab plus nivolumab from the phase III Checkmate 067 study in advanced melanoma
- (2018) S Turajlic et al. ANNALS OF ONCOLOGY
- Different aberrant expression pattern of immune checkpoint receptors in patients with PTCL and NK/T-CL
- (2018) Ziwei Liao et al. Asia-Pacific Journal of Clinical Oncology
- Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor
- (2018) Alexander D. Barrow et al. CELL
- Mechanistic insights into cancer immunity and immunotherapy
- (2018) Weiping Zou Cellular & Molecular Immunology
- Tumor necrosis factor: The key to hepatitis B viral clearance
- (2018) I-Tsu Chyuan et al. Cellular & Molecular Immunology
- IDO1 in cancer: a Gemini of immune checkpoints
- (2018) Lijie Zhai et al. Cellular & Molecular Immunology
- The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation
- (2018) Wenwen Xu et al. Cellular & Molecular Immunology
- Tim-3 expression predicts the abnormal innate immune status and poor prognosis of glioma patients
- (2018) Xueen Li et al. CLINICA CHIMICA ACTA
- Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity
- (2018) Qing Zhang et al. NATURE IMMUNOLOGY
- Checkpoint inhibition: NK cells enter the scene
- (2018) Ana Stojanovic et al. NATURE IMMUNOLOGY
- Immune phenotype of peripheral blood mononuclear cells in patients with high-risk non-muscle invasive bladder cancer
- (2018) François Audenet et al. WORLD JOURNAL OF UROLOGY
- A phase 1 study of lirilumab (antibody against killer immunoglobulin-like receptor antibody KIR2D; IPH2102) in patients with solid tumors and hematologic malignancies
- (2018) Norbert Vey et al. Oncotarget
- IL21 Therapy Combined with PD-1 and Tim-3 Blockade Provides Enhanced NK Cell Antitumor Activity against MHC Class I–Deficient Tumors
- (2018) Hyungseok Seo et al. Cancer Immunology Research
- Coming of Age: CD96 Emerges as Modulator of Immune Responses
- (2018) Hristo Georgiev et al. Frontiers in Immunology
- CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity
- (2018) Amelia Roman Aguilera et al. OncoImmunology
- TIGIT: a novel immunotherapy target moving from bench to bedside
- (2018) Benjamin L. Solomon et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Reduced CD160 expression contributes to impaired NK cell function and poor clinical outcomes in patients with HCC
- (2018) Haoyu Sun et al. CANCER RESEARCH
- The functional potency of natural killer cells in response to IL-2/IL-15/IL-21 stimulation is limited by a concurrent upregulation of Tim-3 in bladder cancer
- (2018) Wei Zhang et al. EXPERIMENTAL CELL RESEARCH
- Dysfunction of natural killer cells mediated by PD-1 and Tim-3 pathway in anaplastic thyroid cancer
- (2018) Ming Yin et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade
- (2018) Joy Hsu et al. JOURNAL OF CLINICAL INVESTIGATION
- Not All Immune Checkpoints Are Created Equal
- (2018) Annika De Sousa Linhares et al. Frontiers in Immunology
- Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells
- (2018) Pascale André et al. CELL
- NKG2A, a New Kid on the Immune Checkpoint Block
- (2018) John B. Haanen et al. CELL
- Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
- (2018) Jun Wang et al. CELL
- Shining light on the significance of NK cell CD56 brightness
- (2018) Sophie M. Poznanski et al. Cellular & Molecular Immunology
- Warm up, cool down, and tearing apart in NK cell memory
- (2018) Lawrence Shih-Hsin Wu et al. Cellular & Molecular Immunology
- Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma
- (2018) Haoyu Sun et al. HEPATOLOGY
- Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial
- (2018) Frank Stephen Hodi et al. LANCET ONCOLOGY
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- (2018) Felix A. Deuss et al. STRUCTURE
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- (2017) Richard Linedale et al. PLoS One
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- (2017) Hyungseok Seo et al. Nature Communications
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- (2017) Kemal Catakovic et al. OncoImmunology
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- Overexpression of CD158 and NKG2A Inhibitory Receptors and Underexpression of NKG2D and NKp46 Activating Receptors on NK Cells in Acute Myeloid Leukemia
- (2016) Daniela Sandoval-Borrego et al. ARCHIVES OF MEDICAL RESEARCH
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- (2016) Karin A. Vineretsky et al. CANCER RESEARCH
- Adaptive NK Cells with Low TIGIT Expression Are Inherently Resistant to Myeloid-Derived Suppressor Cells
- (2016) Dhifaf Sarhan et al. CANCER RESEARCH
- Tim-3 Expression on Tumor-Infiltrating PD-1 + CD8 + T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma
- (2016) Clémence Granier et al. CANCER RESEARCH
- NK cell education via nonclassical MHC and non-MHC ligands
- (2016) Yuke He et al. Cellular & Molecular Immunology
- Liver-infiltrating CD11b−CD27− NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression
- (2016) Qiong-Fang Zhang et al. Cellular & Molecular Immunology
- HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
- (2016) Damien Bertheloot et al. Cellular & Molecular Immunology
- Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma
- (2016) M. Carlsten et al. CLINICAL CANCER RESEARCH
- Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
- (2016) Ana C. Anderson et al. IMMUNITY
- CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma
- (2016) Haoyu Sun et al. IMMUNOLOGY LETTERS
- Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy
- (2016) S. J. Blake et al. Cancer Discovery
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- (2016) Ameet K. Mishra et al. Oncotarget
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- (2016) Yun-Peng Peng et al. Oncotarget
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- (2016) Yayi He et al. Oncotarget
- High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer
- (2016) Cheng Sun et al. OncoImmunology
- Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia
- (2016) Emily M. McWilliams et al. OncoImmunology
- Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy
- (2015) Cheng Sun et al. ACTA PHARMACOLOGICA SINICA
- Human fused NKG2D–IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells
- (2015) Yan Chen et al. Cellular & Molecular Immunology
- TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals
- (2015) Feng Wang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells
- (2015) L. Ruggeri et al. HAEMATOLOGICA
- Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
- (2015) Chamutal Gur et al. IMMUNITY
- The Clinical Significance of Abnormal Tim-3 Expression on NK Cells from Patients with Gastric Cancer
- (2015) Zhenxin Wang et al. IMMUNOLOGICAL INVESTIGATIONS
- Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma
- (2015) Liyun Xu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- TIGIT and PD-1 impair tumor antigen–specific CD8+ T cells in melanoma patients
- (2015) Joe-Marc Chauvin et al. JOURNAL OF CLINICAL INVESTIGATION
- Expression of immune checkpoint molecules of T cell immunoglobulin and mucin protein 3/galectin-9 for NK cell suppression in human gastrointestinal stromal tumors
- (2015) HIDEO KOMITA et al. ONCOLOGY REPORTS
- Erratum: Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL–10 expression and T-cell dysfunction
- (2015) Chen Zhu et al. Nature Communications
- Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells
- (2015) L. Ruggeri et al. HAEMATOLOGICA
- TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway
- (2015) Brian Tomkowicz et al. PLoS One
- LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
- (2014) F. Xu et al. CANCER RESEARCH
- Leukemia-induced phenotypic and functional defects in natural killer cells predict failure to achieve remission in acute myeloid leukemia
- (2014) K. Stringaris et al. HAEMATOLOGICA
- T-cell Immunoglobulin and ITIM Domain (TIGIT) Receptor/Poliovirus Receptor (PVR) Ligand Engagement Suppresses Interferon-γ Production of Natural Killer Cells via β-Arrestin 2-mediated Negative Signaling
- (2014) Man Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TACTILE becomes tangible: CD96 discloses its inhibitory peculiarities
- (2014) Günter Bernhardt NATURE IMMUNOLOGY
- The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions
- (2014) Christopher J Chan et al. NATURE IMMUNOLOGY
- Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade
- (2014) I. P. da Silva et al. Cancer Immunology Research
- T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
- (2013) Joel Crespo et al. CURRENT OPINION IN IMMUNOLOGY
- Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations
- (2013) Haoyu Sun et al. CYTOKINE
- Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR
- (2013) Noa Stanietsky et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Analysis of KIR gene frequencies and HLA class I genotypes in breast cancer and control group
- (2013) Maria Regina Jobim et al. HUMAN IMMUNOLOGY
- CD160 Activation by Herpesvirus Entry Mediator Augments Inflammatory Cytokine Production and Cytolytic Function by NK Cells
- (2013) J. R. Sedy et al. JOURNAL OF IMMUNOLOGY
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- TIM-3 Does Not Act as a Receptor for Galectin-9
- (2013) Judith Leitner et al. PLoS Pathogens
- Lung Tumor Microenvironment Induces Specific Gene Expression Signature in Intratumoral NK Cells
- (2013) Mélanie Gillard-Bocquet et al. Frontiers in Immunology
- Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
- (2012) L. C. Ndhlovu et al. BLOOD
- A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
- (2012) N. Vey et al. BLOOD
- Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9
- (2012) M. K. Gleason et al. BLOOD
- IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
- (2011) D. M. Benson et al. BLOOD
- Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma
- (2011) S. Platonova et al. CANCER RESEARCH
- Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity
- (2011) Emilie Mamessier et al. JOURNAL OF CLINICAL INVESTIGATION
- Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways
- (2011) J. Lee et al. MOLECULAR AND CELLULAR BIOLOGY
- T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B
- (2010) Ying Ju et al. JOURNAL OF HEPATOLOGY
- Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
- (2009) F. Romagne et al. BLOOD
- The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
- (2009) N. Stanietsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
- (2008) Xin Yu et al. NATURE IMMUNOLOGY
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
- (2008) Shawn D Blackburn et al. NATURE IMMUNOLOGY
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