New Insights in Glucocorticoid Receptor Signaling—More Than Just a Ligand-Binding Receptor

The role of glucocorticoids in emotional memory reconsolidation

(2017) Shira Meir Drexler et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation

(2016) José K van den Heuvel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glucocorticoid therapy and ocular hypertension

(2016) Adnan Dibas et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α

(2016) Joseph S. Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy

(2016) Janet P. Hapgood et al.   PHARMACOLOGY & THERAPEUTICS

Activation of the Glucocorticoid Receptor in Acute Inflammation: the SEDIGRAM Concept

(2016) Karolien De Bosscher et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production

(2016) David J. Morgan et al.   Scientific Reports

Rapid Glucocorticoid Feedback Inhibition of ACTH Secretion Involves Ligand-Dependent Membrane Association of Glucocorticoid Receptors

(2015) Qiong Deng et al.   ENDOCRINOLOGY

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo

(2015) Hee-Woong Lim et al.   GENOME RESEARCH

Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds

(2015) Nora Sundahl et al.   PHARMACOLOGY & THERAPEUTICS

GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression

(2015) Guoqiang Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex

(2015) Guoqiang Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the functions of the membrane-bound glucocorticoid receptors: first clues on origin and functional activity

(2014) Cindy Strehl et al.   Annals of the New York Academy of Sciences

Expression microarray identifies the unliganded glucocorticoid receptor as a regulator of gene expression in mammary epithelial cells

(2014) Heather D Ritter et al.   BMC CANCER

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

Peripheral T Cells Are the Therapeutic Targets of Glucocorticoids in Experimental Autoimmune Encephalomyelitis

(2014) S. Wust et al.   JOURNAL OF IMMUNOLOGY

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor

(2014) Diego M. Presman et al.   PLOS BIOLOGY

Endothelial nuclear lamina is not required for glucocorticoid receptor nuclear import but does affect receptor-mediated transcription activation

(2013) Arman Nayebosadri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

(2013) Lars Grøntved et al.   EMBO JOURNAL

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by theTsc22d3gene on the X chromosome

(2013) Iris Pinheiro et al.   EMBO Molecular Medicine

New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation

(2013) Sofie Vandevyver et al.   ENDOCRINOLOGY

Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity

(2013) Amir Hakim et al.   FASEB JOURNAL

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

(2013) Robert H. Oakley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD4+T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection

(2013) David G. Kugler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity

(2013) J. Druker et al.   MOLECULAR AND CELLULAR BIOLOGY

The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals

(2013) Lisa C Watson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Impact of Glucocorticoid Receptor Density on Ligand-Independent Dimerization, Cooperative Ligand-Binding and Basal Priming of Transactivation: A Cell Culture Model

(2013) Steven Robertson et al.   PLoS One

Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator

(2013) I. Zalachoras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

(2013) Nicole A Rapicavoli et al.   eLife

Bayesian Image Analysis of Dexamethasone and Shear Stress-Induced Glucocorticoid Receptor Intracellular Movement

(2012) Arman Nayebosadri et al.   ANNALS OF BIOMEDICAL ENGINEERING

Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction

(2012) Marni N. Silverman et al.   Annals of the New York Academy of Sciences

Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness

(2012) Paul R. Mittelstadt et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

(2012) Sofie Vandevyver et al.   JOURNAL OF CLINICAL INVESTIGATION

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

(2012) Dariusz Ratman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Unliganded Glucocorticoid Receptor Positively Regulates the Tumor Suppressor Gene BRCA1 through GABP Beta

(2012) H. D. Ritter et al.   MOLECULAR CANCER RESEARCH

The Stat3/GR Interaction Code: Predictive Value of Direct/Indirect DNA Recruitment for Transcription Outcome

(2012) David Langlais et al.   MOLECULAR CELL

The structural basis of direct glucocorticoid-mediated transrepression

(2012) William H Hudson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endothelial glucocorticoid receptor is required for protection against sepsis

(2012) J. E. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution

(2012) Steven Robertson et al.   STEROIDS

Glucocorticoids induce mitochondrial gene transcription in HepG2 cells

(2011) Anna-Maria G. Psarra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis

(2011) Rasmus Siersbaek et al.   EMBO JOURNAL

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

(2011) Anna Kleiman et al.   FASEB JOURNAL

Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes

(2011) N. A. S. Rao et al.   GENOME RESEARCH

Glucocorticoid-independent Repression of Tumor Necrosis Factor (TNF) α-stimulated Interleukin (IL)-6 Expression by the Glucocorticoid Receptor

(2011) Nicolette J. D. Verhoog et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

(2011) Deepti Malhotra et al.   JOURNAL OF CLINICAL INVESTIGATION

Ligand-Independent Phosphorylation of the Glucocorticoid Receptor Integrates Cellular Stress Pathways with Nuclear Receptor Signaling

(2011) A. J. Galliher-Beckley et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

(2011) Simon C. Biddie et al.   MOLECULAR CELL

Cell Cycle Phase Regulates Glucocorticoid Receptor Function

(2011) Laura Matthews et al.   PLoS One

Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells

(2011) U. Baschant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back

(2011) Sofie Vandevyver et al.   TRAFFIC

Glucocorticoid receptor mutants: man-made tools for functional research

(2011) Ilse M. Beck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

FKBP51 and FKBP52 in signaling and disease

(2011) Cheryl L. Storer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore

(2011) Mario D. Galigniana et al.   Nucleus

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice

(2010) Rucha Patel et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective Glucocorticoid Receptor modulators

(2010) Karolien De Bosscher   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanisms and resistance in glucocorticoid control of inflammation

(2010) Peter J. Barnes   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The role of the glucocorticoid receptor in inflammation and immunity

(2010) Ulrike Baschant et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanisms Generating Diversity in Glucocorticoid Receptor Signaling

(2009) Javier R. Revollo et al.   Annals of the New York Academy of Sciences

A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance

(2009) V Gossye et al.   ANNALS OF THE RHEUMATIC DISEASES

Glucocorticoid receptor (GR) β has intrinsic, GRα-independent transcriptional activity

(2009) Tomoshige Kino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action

(2009) Emira Ayroldi et al.   FASEB JOURNAL

Nuclear Import of the Glucocorticoid Receptor-hsp90 Complex through the Nuclear Pore Complex Is Mediated by Its Interaction with Nup62 and Importin  

(2009) P. C. Echeverria et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic and Nongenomic Cross Talk between the Gonadotropin-Releasing Hormone Receptor and Glucocorticoid Receptor Signaling Pathways

(2009) Andrea Kotitschke et al.   MOLECULAR ENDOCRINOLOGY

Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player

(2009) H. Gronemeyer et al.   Science Signaling

The human glucocorticoid receptor: Molecular basis of biologic function

(2009) Nicolas C. Nicolaides et al.   STEROIDS

Dose-related patterns of glucocorticoid-induced side effects

(2008) D Huscher et al.   ANNALS OF THE RHEUMATIC DISEASES

Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids

(2008) Karolien De Bosscher et al.   MOLECULAR ENDOCRINOLOGY

HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment

(2008) C. Colussi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands

(2008) M LOWENBERG et al.   STEROIDS