Covid-19 and Diabetes: A Complex Bidirectional Relationship

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

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Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

(2020) Livio Luzi et al.   ACTA DIABETOLOGICA

Hypertension and COVID-19

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Severe COVID‐19 infection and thrombotic microangiopathy: success does not come easily

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Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

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SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Will Complement Inhibition Be the New Target in Treating COVID-19–Related Systemic Thrombosis?

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Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Outcomes in Patients With Hyperglycemia Affected by Covid-19: Can We Do More on Glycemic Control?

(2020) Celestino Sardu et al.   DIABETES CARE

COVID-19, diabetes mellitus and ACE2: The conundrum

(2020) Rimesh Pal et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Diabetes is a risk factor for the progression and prognosis of COVID-19

(2020) Weina Guo et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Guidance on the management of Diabetic Ketoacidosis in the exceptional circumstances of the COVID‐19 pandemic

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Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

(2020) Bertrand Cariou et al.   DIABETOLOGIA

Coronavirus Infections and Type 2 Diabetes—Shared Pathways with Therapeutic Implications

(2020) Daniel J Drucker   ENDOCRINE REVIEWS

Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis

(2020) Wei-jie Guan et al.   EUROPEAN RESPIRATORY JOURNAL

Covid-19 and immunomodulation in IBD

(2020) Markus F Neurath   GUT

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation

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COVID-19 update: Covid-19-associated coagulopathy

(2020) Richard C. Becker   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

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COVID‐19 and liver disease

(2020) Jian Sun et al.   LIVER INTERNATIONAL

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Interaction between RAAS inhibitors and ACE2 in the context of COVID-19

(2020) Jean-Jacques Mourad et al.   Nature Reviews Cardiology

Obesity and impaired metabolic health in patients with COVID-19

(2020) Norbert Stefan et al.   Nature Reviews Endocrinology

High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation

(2020) Arthur Simonnet et al.   Obesity

Cytokine release syndrome in severe COVID-19

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How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes

(2020) Meredith Wadman   SCIENCE

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

Prevalence of obesity among adult inpatients with COVID-19 in France

(2020) Cyrielle Caussy et al.   Lancet Diabetes & Endocrinology

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Hyperglycaemia on admission to hospital and COVID-19

(2020) Celestino Sardu et al.   DIABETOLOGIA

Can pioglitazone be potentially useful therapeutically in treating patients with COVID-19?

(2020) Elena Carboni et al.   MEDICAL HYPOTHESES

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

(2020) Yanwei Li et al.   PHARMACOLOGICAL RESEARCH

Dexamethasone in the management of covid -19

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Could anti‐hypertensive drug therapy affect the clinical prognosis of hypertensive patients with COVID‐19 infection? Data from centers of southern Italy

(2020) Celestino Sardu et al.   Journal of the American Heart Association

Practical recommendations for the management of diabetes in patients with COVID-19

(2020) Stefan R Bornstein et al.   Lancet Diabetes & Endocrinology

The MERS-CoV Receptor DPP4 as a Candidate Binding Target of the SARS-CoV-2 Spike

(2020) Yu Li et al.   iScience

Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease

(2019) Hiddo J. L. Heerspink et al.   DIABETOLOGIA

Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice

(2019) Robin Shoemaker et al.   Biology of Sex Differences

Microangiopathy: Is it relevant to wound healing in diabetic foot disease?

(2019) Sanjeev Sharma et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus–induced type 2 responses and immunopathology

(2018) Melissa H. Bloodworth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease

(2018) Fabrice Bonnet et al.   DIABETES & METABOLISM

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice

(2016) Feng Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control

(2016) Young-Sun Lee et al.   MEDIATORS OF INFLAMMATION

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats

(2015) Marina Romaní-Pérez et al.   ENDOCRINOLOGY

Glucagon Like Peptide-1 (GLP-1) Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB (NF-κB) Signaling Pathway in Mice

(2015) Tao Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect

(2015) Yoshifumi Saisho   Endocrine Metabolic & Immune Disorders-Drug Targets

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

Incretin-Based Therapies, Glucometabolic Health and Endovascular Inflammation

(2014) Manfredi Rizzo et al.   CURRENT PHARMACEUTICAL DESIGN

The dipeptidyl peptidase-4 inhibitor vildagliptin does not affect ex vivo cytokine response and lymphocyte function in patients with type 2 diabetes mellitus

(2014) P.C.M. van Poppel et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Glucagon like peptide-1 attenuates bleomycin-induced pulmonary fibrosis, involving the inactivation of NF-κB in mice

(2014) Si GOU et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pioglitazone attenuates lung injury by modulating adipose inflammation

(2014) Masahiko Kutsukake et al.   JOURNAL OF SURGICAL RESEARCH

β-Cell function in type 2 diabetes

(2014) Ele Ferrannini et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

(2013) Devjit Tripathy et al.   DIABETOLOGIA

Glucagon-Like Peptide-1 (GLP-1) Reduces Mortality and Improves Lung Function in a Model of Experimental Obstructive Lung Disease in Female Mice

(2013) Niels-Erik Viby et al.   ENDOCRINOLOGY

Thrombotic microangiopathy: new insights

(2010) Kerstin Benz et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

ACE2 and Diabetes: ACE of ACEs?

(2010) D. Batlle et al.   DIABETES

Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

(2009) Jin-Kui Yang et al.   ACTA DIABETOLOGICA

Metformin inhibits nuclear factor κB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits

(2009) Song-Nan Li et al.   HEART AND VESSELS

Pioglitazone Inhibits the Expression of Inflammatory Cytokines From Both Monocytes and Lymphocytes in Patients With Impaired Glucose Tolerance

(2008) Wei-Yang Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Suppresses Bleomycin-Induced Acute Lung Injury and Fibrosis

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Pathogenetic mechanisms of severe acute respiratory syndrome

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