Covid-19 and immunomodulation in IBD

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

Predicting, Preventing, and Managing Treatment-related Complications in Patients With Inflammatory Bowel Diseases.

(2020) Laurent Beaugerie et al.   Clinical Gastroenterology and Hepatology

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Coronavirus infections and immune responses

(2020) Geng Li et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

(2020) Clark D Russell et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Nutritional Aspects in Inflammatory Bowel Diseases

(2020) Paola Balestrieri et al.   Nutrients

Fecal Serine Protease Profiling in Inflammatory Bowel Diseases

(2020) Amin Jablaoui et al.   Frontiers in Cellular and Infection Microbiology

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Systematic review with meta-analysis: biologics and risk of infection or cancer in elderly patients with inflammatory bowel disease

(2020) Daniele Piovani et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

(2020) Daniel Batlle et al.   CLINICAL SCIENCE

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

(2020) Xi Jin et al.   GUT

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

(2020) Wenling Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2: a storm is raging

(2020) Savannah F. Pedersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory Bowel Disease Care in the COVID-19 Pandemic Era: The Humanitas, Milan, Experience

(2020) Gionata Fiorino et al.   Journal of Crohns & Colitis

Covid‐19 and the digestive system

(2020) Sunny H Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

COVID-19 spike-host cell receptor GRP78 binding site prediction

(2020) Ibrahim M. Ibrahim et al.   JOURNAL OF INFECTION

Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia

(2020) Siyu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID‐19

(2020) Yong Gao et al.   JOURNAL OF MEDICAL VIROLOGY

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

(2020) Dandan Wu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

Management of IBD during the COVID-19 outbreak: resetting clinical priorities

(2020) Silvio Danese et al.   Nature Reviews Gastroenterology & Hepatology

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study

(2020) Dan Sun et al.   World Journal of Pediatrics

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

COVID-19 and smoking: A systematic review of the evidence

(2020) Constantine Vardavas et al.   Tobacco Induced Diseases

Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)

(2020) Samuel James Brake et al.   Journal of Clinical Medicine

Implications of COVID-19 for patients with pre-existing digestive diseases

(2020) Ren Mao et al.   Lancet Gastroenterology & Hepatology

Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2

(2020) Saif ur Rehman et al.   Pathogens

Real-World Experience with Tofacitinib in IBD at a Tertiary Center

(2019) Roni Weisshof et al.   DIGESTIVE DISEASES AND SCIENCES

Comparative Risk of Serious Infections With Biologic and/or Immunosuppressive Therapy in Patients with Inflammatory Bowel Diseases: a Systematic Review and Meta-analysis

(2019) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Quantitative Proteomic Analysis Reveals the Deregulation of Nicotinamide Adenine Dinucleotide Metabolism and CD38 in Inflammatory Bowel Disease

(2019) LongGui Ning et al.   Biomed Research International

Overall and comparative safety of biologic and immunosuppressive therapy in inflammatory bowel diseases

(2019) Ariela Holmer et al.   Expert Review of Clinical Immunology

Targeting immune cell circuits and trafficking in inflammatory bowel disease

(2019) Markus F. Neurath   NATURE IMMUNOLOGY

Imbalance of the renin–angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

(2019) Mayur Garg et al.   GUT

Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis

(2019) Bruce E. Sands et al.   NEW ENGLAND JOURNAL OF MEDICINE

An open-label phase 1 clinical trial of the anti-α4β7 monoclonal antibody vedolizumab in HIV-infected individuals

(2019) Michael C. Sneller et al.   Science Translational Medicine

TNF activity and T cells

(2018) Amit K. Mehta et al.   CYTOKINE

IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting

(2018) Alexander R. Moschen et al.   Nature Reviews Gastroenterology & Hepatology

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals

(2018) Mathieu Uzzan et al.   Science Translational Medicine

Randomised trial and open-label extension study of an anti-interleukin-6 antibody in Crohn’s disease (ANDANTE I and II)

(2017) Silvio Danese et al.   GUT

MAS1 Receptor Trafficking Involves ERK1/2 Activation Through a β-Arrestin2–Dependent PathwayNovelty and Significance

(2017) Flavia M. Cerniello et al.   HYPERTENSION

The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohnʼs Disease Effector T Cells In Vivo

(2017) Sebastian Zundler et al.   INFLAMMATORY BOWEL DISEASES

Human T cell immunosenescence and inflammation in aging

(2017) Arsun Bektas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

(2016) Bita Shakoory et al.   CRITICAL CARE MEDICINE

Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease

(2016) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sustained virologic control in SIV+ macaques after antiretroviral and  4 7 antibody therapy

(2016) S. N. Byrareddy et al.   SCIENCE

Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo

(2016) Eitan Wong et al.   Scientific Reports

Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation

(2016) Masayuki Shimoda et al.   EBioMedicine

Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis

(2016) Maitham A. Khajah et al.   PLoS One

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

(2015) Anika Fischer et al.   GUT

A Phase 2 Study of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients With Crohn’s Disease

(2014) William J. Sandborn et al.   Clinical Gastroenterology and Hepatology

Anti-TNF-α therapy for patients with sepsis: a systematic meta-analysis

(2014) S. Lv et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Upregulation of circulating components of the alternative renin-angiotensin system in inflammatory bowel disease: A pilot study

(2014) Mayur Garg et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

(2014) Raja Atreya et al.   NATURE MEDICINE

Adult haemophagocytic syndrome

(2013) Manuel Ramos-Casals et al.   LANCET

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-23: One cytokine in control of autoimmunity

(2012) Andrew L. Croxford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting IL-23 and Th17-Cytokines in Inflammatory Bowel Diseases

(2010) Daniela De Nitto et al.   CURRENT PHARMACEUTICAL DESIGN

Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

(2010) Jean Frédéric Colombel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2

(2009) Jan Wysocki et al.   HYPERTENSION

Effects of the ACE2 inhibitor GL1001 on acute dextran sodium sulfate-induced colitis in mice

(2009) John J. Byrnes et al.   INFLAMMATION RESEARCH

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY