Metabolic Improvement via Enhancing Thermogenic Fat-Mediated Non-shivering Thermogenesis: From Rodents to Humans

Activated brown adipose tissue and its relationship to adiposity and metabolic markers: an exploratory study

(2020) Malini Soundarrajan et al.   Adipocyte

Functional characterization of human brown adipose tissue metabolism

(2020) Marie Anne Richard et al.   BIOCHEMICAL JOURNAL

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

(2020) Brian S. Finlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

(2020) Alana E. O’Mara et al.   JOURNAL OF CLINICAL INVESTIGATION

Combating Obesity With Thermogenic Fat: Current Challenges and Advancements

(2020) Ruping Pan et al.   Frontiers in Endocrinology

Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis

(2019) Xing Zeng et al.   NATURE

Brown Adipose Tissue: Multimodality Evaluation by PET, MRI, Infrared Thermography, and Whole‐Body Calorimetry (TACTICAL‐II)

(2019) Lijuan Sun et al.   Obesity

An optimal condition for the evaluation of human brown adipose tissue by infrared thermography

(2019) Shinsuke Nirengi et al.   PLoS One

Association of circulating exosomal miR-122 levels with BAT activity in healthy humans

(2019) Yuko Okamatsu-Ogura et al.   Scientific Reports

Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

(2018) Mueez U Din et al.   Cell Metabolism

Non-adrenergic control of lipolysis and thermogenesis in adipose tissues

(2018) Katharina Braun et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Capsaicin in Metabolic Syndrome

(2018) Sunil Panchal et al.   Nutrients

Mineralocorticoid Antagonism Enhances Brown Adipose Tissue Function In Humans: A Randomized Placebo-controlled Cross-over Study

(2018) Moe Thuzar et al.   DIABETES OBESITY & METABOLISM

Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT

(2018) Minna Lahesmaa et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Cardiovascular risk profile in individuals initiating treatment for overactive bladder – Challenges and learnings for comparative analysis using linked claims and electronic medical record databases

(2018) E. Vonesh et al.   PLoS One

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

(2018) Yongguo Li et al.   CELL

Vibegron: First Global Approval

(2018) Susan J. Keam   DRUGS

Thermal stress induces glycolytic beige fat formation via a myogenic state

(2018) Yong Chen et al.   NATURE

Vibegron (RVT-901/MK-4618/KRP-114V) Administered Once Daily as Monotherapy or Concomitantly with Tolterodine in Patients with an Overactive Bladder: A Multicenter, Phase IIb, Randomized, Double-blind, Controlled Trial

(2018) Henry D. Mitcheson et al.   EUROPEAN UROLOGY

Four-week cold acclimation in adult humans shifts uncoupling thermogenesis from skeletal muscles to brown adipose tissue

(2017) Denis P. Blondin et al.   JOURNAL OF PHYSIOLOGY-LONDON

LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men

(2017) Mariëtte R. Boon et al.   Metabolomics

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

(2017) Denis P. Blondin et al.   Nature Communications

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice

(2016) Lavanya Vishvanath et al.   Cell Metabolism

Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus

(2016) Mueez u Din et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

(2016) Yong Chen et al.   Nature Communications

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Genetic and functional characterization of clonally derived adult human brown adipocytes

(2015) Kosaku Shinoda et al.   NATURE MEDICINE

Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat

(2015) Jean Z. Lin et al.   Cell Reports

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

(2014) Andrea Armani et al.   FASEB JOURNAL

The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality

(2014) Margalit Goldgof et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans

(2014) Denis P. Blondin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

(2014) Thorsten Gnad et al.   NATURE

Brown adipose tissue activity after a high-calorie meal in humans

(2013) Maarten J Vosselman et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma

(2013) Andrea Frontini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

(2013) Yun-Hee Lee et al.   Cell Metabolism

Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans

(2013) M Matsushita et al.   INTERNATIONAL JOURNAL OF OBESITY

Hyperthyroidism Increases Brown Fat Metabolism in Humans

(2013) Minna Lahesmaa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat

(2013) O. Muzik et al.   JOURNAL OF NUCLEAR MEDICINE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Assessment of Oxidative Metabolism in Brown Fat Using PET Imaging

(2012) Otto Muzik et al.   Frontiers in Endocrinology

Challenges in β3-adrenoceptor agonist drug development

(2011) Jonathan R. S. Arch   Therapeutic Advances in Endocrinology and Metabolism

β3 Receptors: role in cardiometabolic disorders

(2011) Shraddha V. Bhadada et al.   Therapeutic Advances in Endocrinology and Metabolism

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Brown Fat and the Myth of Diet-Induced Thermogenesis

(2010) Leslie P. Kozak   Cell Metabolism

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE