Biomarkers of Activation and Inflammation to Track Disparity in Chronological and Physiological Age of People Living With HIV on Combination Antiretroviral Therapy

SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction

(2020) Jennifer Gorwood et al.   Cells

Upregulation of circulating inflammatory biomarkers under the influence of periodontal disease in rheumatoid arthritis patients

(2020) Jeneen Panezai et al.   CYTOKINE

Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV + Individuals: Implications for Atherogenesis

(2019) Meera V Singh et al.   CIRCULATION

Protein damage, ageing and age-related diseases

(2019) Anita Krisko et al.   Open Biology

Circulating (1→3)-β-D-Glucan is associated with immune activation during HIV infection

(2019) Vikram Mehraj et al.   CLINICAL INFECTIOUS DISEASES

Effects of comorbidity burden and Age on brain integrity in HIV

(2019) Rowan Saloner et al.   AIDS

Inflammation-related genes are associated with epigenetic aging in HIV

(2019) Erin E. Sundermann et al.   JOURNAL OF NEUROVIROLOGY

S100B and its association with HIV-associated neurocognitive disorders

(2019) Nath Limpruttidham et al.   JOURNAL OF NEUROVIROLOGY

Limited correlation between systemic biomarkers and neurocognitive performance before and during HIV treatment

(2019) Kevin Robertson et al.   JOURNAL OF NEUROVIROLOGY

Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy

(2019) Hemalatha Babu et al.   Frontiers in Immunology

Plasma inflammatory biomarkers link to diffusion tensor imaging metrics in virally suppressed HIV-infected individuals

(2019) Kevin Chang et al.   AIDS

Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice

(2019) Parag Kundu et al.   Science Translational Medicine

ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy

(2019) Juan Zhao et al.   Frontiers in Immunology

Circulating levels of ATP is a biomarker of HIV cognitive impairment

(2019) Stephani Velasquez et al.   EBioMedicine

Achieving the fourth 90

(2018) Tiffany G. Harris et al.   AIDS

High complement levels in astrocyte-derived exosomes of Alzheimer disease

(2018) Edward J. Goetzl et al.   ANNALS OF NEUROLOGY

Developing TRAIL/TRAIL death receptor-based cancer therapies

(2018) Xun Yuan et al.   CANCER AND METASTASIS REVIEWS

DNA damage, metabolism and aging in pro-inflammatory T cells

(2018) Yinyin Li et al.   EXPERIMENTAL GERONTOLOGY

Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities

(2018) Michelle L D’Antoni et al.   JOURNAL OF INFECTIOUS DISEASES

CCL23: a new CC chemokine involved in human brain damage

(2018) A. Simats et al.   JOURNAL OF INTERNAL MEDICINE

Altered White Matter Integrity in Human Immunodeficiency Virus-Associated Neurocognitive Disorder: A Tract-Based Spatial Statistics Study

(2018) Se Won Oh et al.   KOREAN JOURNAL OF RADIOLOGY

HIV and aging

(2018) Seema N. Desai et al.   Current Opinion in HIV and AIDS

Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy

(2018) Sukrutha Chettimada et al.   Scientific Reports

CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres

(2018) Dorota Piekna-Przybylska et al.   CELL CYCLE

Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice

(2018) Stephanie M. Matt et al.   Frontiers in Immunology

Atrophic brain signatures of mild forms of neurocognitive impairment in virally suppressed HIV infection

(2018) Madeleine J. Nichols et al.   AIDS

Inflammation Relates to Poorer Complex Motor Performance Among Adults Living With HIV on Suppressive Antiretroviral Therapy

(2018) Jessica L. Montoya et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

White matter damage, neuroinflammation, and neuronal integrity in HAND

(2018) Aljoharah Alakkas et al.   JOURNAL OF NEUROVIROLOGY

Global and regional trends of people living with HIV aged 50 and over: Estimates and projections for 2000–2020

(2018) Christine S. Autenrieth et al.   PLoS One

An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men

(2018) Abigail J. S. Armstrong et al.   Microbiome

Elevated interferon-γ–induced protein 10 and its receptor CXCR3 impair NK cell function during HIV infection

(2017) Zhuo Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration

(2017) Lucette A. Cysique et al.   JOURNAL OF NEUROVIROLOGY

Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

(2017) Hong-Yi Zheng et al.   Scientific Reports

Inflammation, Immune Activation, and Antiretroviral Therapy in HIV

(2017) Corrilynn O. Hileman et al.   Current HIV/AIDS Reports

Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?

(2017) Shyam Sushama Jose et al.   Frontiers in Immunology

T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection

(2017) Suresh Pallikkuth et al.   Frontiers in Immunology

Premature aging and immune senescence in HIV-infected children

(2016) Ketty Gianesin et al.   AIDS

Mechanisms of HIV Neuropathogenesis: Role of Cellular Communication Systems

(2016) Shaily Malik et al.   CURRENT HIV RESEARCH

HIV-associated changes in the enteric microbial community

(2016) David B. Gootenberg et al.   CURRENT OPINION IN INFECTIOUS DISEASES

CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population

(2016) Tanawan Riangwiwat et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment

(2016) Viviana Cobos Jiménez et al.   JOURNAL OF INFECTIOUS DISEASES

Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1–Infected Individuals

(2016) Troels Bygum Knudsen et al.   JOURNAL OF INFECTIOUS DISEASES

Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA

(2016) Andrew M. Gross et al.   MOLECULAR CELL

Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment

(2016) Arvid Edén et al.   PLoS One

Plasma CXCL10, sCD163 and sCD14 Levels Have Distinct Associations with Antiretroviral Treatment and Cardiovascular Disease Risk Factors

(2016) Alison Castley et al.   PLoS One

Shocking HIV out of hiding

(2016) Thomas A. Rasmussen et al.   Current Opinion in HIV and AIDS

Human adipose tissue as a reservoir for memory CD4+ T cells and HIV

(2015) Jacob Couturier et al.   AIDS

Soluble CD14 is a nonspecific marker of monocyte activation

(2015) Carey L. Shive et al.   AIDS

Associations of Soluble CD14 and Endotoxin with Mortality, Cardiovascular Disease, and Progression of Kidney Disease among Patients with CKD

(2015) R. Poesen et al.   Clinical Journal of the American Society of Nephrology

Modulation of Cellular Function Through Immune-Activated Exosomes

(2015) Lynn Pulliam et al.   DNA AND CELL BIOLOGY

Immune activation in the course of HIV-1 infection: Causes, phenotypes and persistence under therapy

(2015) M Younas et al.   HIV MEDICINE

Soluble biomarkers of immune activation and inflammation in HIV infection: impact of 2 years of effective first-line combination antiretroviral therapy

(2015) S Hattab et al.   HIV MEDICINE

Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA

(2015) Gavin C. Sampey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Infection Accelerates Age According to the Epigenetic Clock

(2015) Steve Horvath et al.   JOURNAL OF INFECTIOUS DISEASES

Effect of Probiotic Supplement on Cytokine Levels in HIV-Infected Individuals: A Preliminary Study

(2015) Katia Falasca et al.   Nutrients

Circulating HIV DNA Correlates With Neurocognitive Impairment in Older HIV-infected Adults on Suppressive ART

(2015) Michelli Faria de Oliveira et al.   Scientific Reports

Neuropathogenesis of HIV: From Initial Neuroinvasion to HIV-Associated Neurocognitive Disorder (HAND)

(2015) Zaina Zayyad et al.   Current HIV/AIDS Reports

Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the “Probio-HIV” Clinical Trial

(2015) Gabriella d’Ettorre et al.   PLoS One

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Gut Epithelial Barrier Dysfunction and Innate Immune Activation Predict Mortality in Treated HIV Infection

(2014) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART

(2014) L. A. Ramirez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Elevated Plasma Soluble CD14 and Skewed CD16+ Monocyte Distribution Persist despite Normalisation of Soluble CD163 and CXCL10 by Effective HIV Therapy: A Changing Paradigm for Routine HIV Laboratory Monitoring?

(2014) Alison Castley et al.   PLoS One

Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection

(2013) Tricia H. Burdo et al.   AIDS

The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults

(2013) Talía Sainz et al.   AIDS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Protein oxidation in aging and the removal of oxidized proteins

(2013) Annika Höhn et al.   Journal of Proteomics

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter

(2013) K. J. Kallianpur et al.   NEUROLOGY

Increased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases

(2013) Johanna Gaiottino et al.   PLoS One

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

NTRK3 Is a Potential Tumor Suppressor Gene Commonly Inactivated by Epigenetic Mechanisms in Colorectal Cancer

(2013) Yanxin Luo et al.   PLoS Genetics

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Markers of microbial translocation and risk of AIDS-related lymphoma

(2012) Morgan A. Marks et al.   AIDS

Cognitive disorders in HIV-infected patients

(2012) Fabrice Bonnet et al.   AIDS

CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects

(2012) Anders Etzerodt et al.   ANTIOXIDANTS & REDOX SIGNALING

Independent Effects of HIV, Aging, and HAART on Brain Volumetric Measures

(2012) Beau M. Ances et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study

(2012) Tong Zhu et al.   JOURNAL OF NEUROVIROLOGY

A diffusion tensor imaging and neuropsychological study of prospective memory impairment in South African HIV positive individuals

(2012) Hoare Jacqueline et al.   METABOLIC BRAIN DISEASE

Microbial translocation in HIV infection: causes, consequences and treatment opportunities

(2012) Netanya G. Sandler et al.   NATURE REVIEWS MICROBIOLOGY

A comparative evaluation of quantitative neuroimaging measurements of brain status in HIV infection

(2012) Hongyan Du et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients

(2011) Victor Appay et al.   AIDS

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

(2011) Jarek Harezlak et al.   AIDS

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Plasma sCD14 Is a Biomarker Associated With Impaired Neurocognitive Test Performance in Attention and Learning Domains in HIV Infection

(2011) Jennifer L Lyons et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Protein changes in CSF of HIV-infected patients: evidence for loss of neuroprotection

(2011) Rick B. Meeker et al.   JOURNAL OF NEUROVIROLOGY

Factors affecting brain structure in men with HIV disease in the post-HAART era

(2011) James T. Becker et al.   NEURORADIOLOGY

S100B protein in the gut: The evidence for enteroglial-sustained intestinal inflammation

(2011) Carla Cirillo   WORLD JOURNAL OF GASTROENTEROLOGY

HIV-associated neurocognitive disorders: is there a hidden epidemic?

(2010) Justin C McArthur et al.   AIDS

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Selective increase of activation antigens HLA-DR and CD38 on CD45RO+ T lymphocytes during HIV-1 infection

(2010) L. KESTENS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immune Exhaustion Occurs Concomitantly With Immune Activation and Decrease in Regulatory T Cells in Viremic Chronically HIV-1–Infected Patients

(2010) Meenakshi Sachdeva et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Serum Levels of the Immune Activation Marker Neopterin Change With Age and Gender and Are Modified by Race, BMI, and Percentage of Body Fat

(2010) M. E. Spencer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Brain metabolism and cognitive impairment in HIV infection: a 3-T magnetic resonance spectroscopy study

(2010) Mona A. Mohamed et al.   MAGNETIC RESONANCE IMAGING

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton

(2010) P. U. Cameron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage signaling in HIV-1 infection

(2010) Georges Herbein et al.   Retrovirology

Histone deacetylase inhibitors and HIV latency

(2010) David M Margolis   Current Opinion in HIV and AIDS

Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection

(2010) Lars Hagberg et al.   AIDS Research and Therapy

Frontostriatal fiber bundle compromise in HIV infection without dementia

(2009) Adolf Pfefferbaum et al.   AIDS

Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties

(2009) Jason A. Luther et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

(2009) A. R. Stacey et al.   JOURNAL OF VIROLOGY

CKβ8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKCδ/NF-κB and is involved in inflammatory responses

(2009) Jeonghan Kim et al.   LIFE SCIENCES

White matter abnormalities revealed by diffusion tensor imaging in non-demented and demented HIV+ patients

(2009) Yasheng Chen et al.   NEUROIMAGE

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor α, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor

(2008) Inmaculada Rioja et al.   ARTHRITIS AND RHEUMATISM

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

(2008) B. D. Lehmann et al.   CANCER RESEARCH

Relative sensitivity of magnetic resonance spectroscopy and quantitative magnetic resonance imaging to cognitive function among nondemented individuals infected with HIV

(2008) ROBERT H. PAUL et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies

(2008)   LANCET

Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: Application to proton MR Spectroscopy (MRS) in HIV-related neurological injury

(2007) Constantin T. Yiannoutsos et al.   NEUROIMAGE