Review
Pharmacology & Pharmacy
Aiping Zheng, Lei Zhang, Jiaqing Yang, Xiaomeng Yin, Tao Zhang, Xin Wu, Xuelei Ma
Summary: Exercise plays a crucial role in preventing cancer metastasis by modulating immune cell behavior, lowering the risk of recurrence and improving survival rates for cancer patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yasunari Matsuzaka, Ryu Yashiro
Summary: Self-tolerance is a process that protects against self-reactive B and T cells through negative selection, programmed cell death, and inhibition of regulatory T cells. Exosomes, small extracellular vesicles, can deliver microRNAs to modulate the immune response by regulating gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Seyedeh Alia Moosavian, Maryam Hashemi, Leila Etemad, Sara Daneshmand, Zahra Salmasi
Summary: Exosomes play a crucial role in early diagnosis and various functions related to angiogenesis, immune modulation, migration, metastasis, chemotherapy resistance, and tumor progression in melanoma. Natural exosomes have the potential to be utilized as nanocarriers and cancer vaccines for more efficient cancer treatment in the era of novel bioengineering and immunotherapy approaches.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Virology
Shupeng Dong, Maggie Z. X. Xiao, Qiming Liang
Summary: This review summarizes the functions of 10 proteins encoded by ZIKV and their roles in virus replication and pathogenesis based on studies published in the past 6 years.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Yue Zhang, Yan Yan, Jingjing Meng, Mohit Girotra, Sundaram Ramakrishnan, Sabita Roy
Summary: Extracellular vesicles (EVs) serve as effective mediators of intercellular communication between enterocytes and immune cells, modulating inflammatory responses through microRNA, especially Let-7. Studies using in vitro and murine models demonstrated that EVs derived from intestinal organoids can reduce inflammation and alleviate colitis symptoms, with opioid use exacerbating immune responses in inflammatory diseases.
MUCOSAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Haile Liu, Yonghui Li, Si Sun, Qi Xin, Shuhu Liu, Xiaoyu Mu, Xun Yuan, Ke Chen, Hao Wang, Kalman Varga, Wenbo Mi, Jiang Yang, Xiao-Dong Zhang
Summary: Clusterzymes based on Au-25 clusters exhibit high catalytic activity and selectivity in enzyme-mimicking reactions, such as GPx-like, CAT-like, and SOD-like activities. They can effectively decrease oxidative stress and inflammation in injured brain, showing promise in mitigating neuroinflammation.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Natalia Diaz-Garrido, Josefa Badia, Laura Baldoma
Summary: This study aimed to understand the mechanisms of extracellular vesicles (BEVs) in driving specific immune responses. The production of cytokines and exosomes by dendritic cells (DCs) challenged with BEVs from different strains of E. coli was analyzed. The results showed that the strains had differential effects on the production of specific cytokines and the composition of immune-related miRNA in the exosomes.
Article
Hematology
Wenjing Miao, Baoquan Song, Bingyu Shi, Qi Wan, Quansheng Lv, Hanqing Chen, Mingqing Zhu, Leisheng Zhang, Yue Han, Depei Wu
Summary: Reduced megakaryocyte apoptosis and insufficient platelet production are key factors in immune thrombocytopenia (ITP). Plasma-derived exosomes from ITP patients contribute to decreased platelet count. ITP-Exo reduces megakaryocyte apoptosis and platelet production through Bcl-xL/caspase signaling, unveiling new mechanisms for reduced platelet count in ITP.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Ilona Mihaela Liliac, Bogdan Silviu Ungureanu, Claudiu Margaritescu, Victor Mihai Sacerdotianu, Adrian Saftoiu, Laurentiu Mogoanta, Emil Moraru, Daniel Pirici
Summary: This study investigates the expression and regulation mechanism of E-cadherin in gastric cancer tissue. The findings suggest that E-cadherin is more abundantly synthesized than eliminated via lysosomes/exosomes in less differentiated tumors, leading to a significant decrease in its expression on the membrane. Moreover, this study provides the first evidence of the trafficking of Lysosome-associated membrane glycoprotein 1 (LAMP1)-positive exosomes/multivesicular bodies across the membranes of tumor cells.
Article
Biochemical Research Methods
Katherine E. Rogers, Okhil K. Nag, Kimihiro Susumu, Eunkeu Oh, James B. Delehanty
Summary: In mammalian cells, the plasma membrane potential is controlled by a network of membrane-resident ion channels. Previous work has utilized spherical gold nanoparticles (AuNS) to induce membrane depolarization. In this study, new anisotropic-shaped gold nanoflowers (AuNFs) with absorption in the near-infrared range were used to effectively depolarize cells.
BIOCONJUGATE CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Mahrou Vahabi, Annalisa Comandatore, Marika A. Franczak, Ryszard T. Smolenski, Godefridus J. Peters, Luca Morelli, Elisa Giovannetti
Summary: Exosomes play a crucial role in intercellular communication and can influence cancer cell behavior and response to treatment. They can transport glycolytic enzymes, leading to altered glucose metabolism and increased tumor progression, survival, immune evasion, and drug resistance. Understanding exosome-mediated cell-to-cell communication may open new therapeutic avenues and facilitate biomarker development, and combining exosome-based-targeted therapies with existing treatments holds promise in overcoming resistance and improving cancer treatment outcomes.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Immunology
Qingkun Liu, Siamak K. Sorooshyari
Summary: The article investigates the cellular dynamics of immune responses in the central nervous system and periphery post stroke, highlighting correlations between different cell types in the brain and spleen following stroke. Findings suggest a synergistic effect between infiltrated macrophages and neutrophils in the ischemic hemisphere, as well as a positive correlation between neutrophils and T cells. Furthermore, the correlation between neurological deficits and immune cells indicates that microglia and splenic adaptive immune cells are protective, while infiltrating peripheral myeloid cells exacerbate stroke outcomes. Understanding these immune responses is crucial for predicting stroke outcomes and identifying therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Yuka Li, Eisuke Kanao, Tomoyoshi Yamano, Yasushi Ishihama, Koshi Imami
Summary: Researchers developed a system to track the uptake of extracellular vesicles (EVs) by recipient cells, and identified 456 recipient proteins involved in EV uptake. This study provides an important tool for understanding the mechanism of EV uptake.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ellen Poot, Ander Maguregui, Valerie G. Brunton, Dirk Sieger, Alison N. Hulme
Summary: This review explores the combination of particle delivery systems and immunotherapy for the effective treatment of glioblastoma multiforme (GBM) over the past three years.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Environmental Sciences
Yuehua Li, Baohong Jiang, Lijun Zeng, Yuanbin Tang, Xiaowen Qi, Zhixing Wan, Wenjie Feng, Liming Xie, Rongfang He, Hongbo Zhu, Yimou Wu
Summary: Obesity is strongly associated with adverse prognosis in TNBC. Adipose-secreted exo-circCRIM1 promotes TNBC progression by inhibiting miR-503-5p and activating the OGA/FBP1 signaling pathway.
ENVIRONMENTAL RESEARCH
(2023)
