Colonic treatments and targets: issues and opportunities

Mucoadhesion and the Gastrointestinal Tract

(2012) Felipe J. O. Varum et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Probiotics and Irritable Bowel Syndrome

(2010) Michael Camilleri   JOURNAL OF CLINICAL GASTROENTEROLOGY

Oral, colonic-release low-molecular-weight heparin: an initial open study of Parnaparin-MMX for the treatment of mild-to-moderate left-sided ulcerative colitis

(2008) L. PASTORELLI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A new concept in colonic drug targeting: a combined pH-responsive and bacterially-triggered drug delivery technology

(2008) V. C. IBEKWE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effect of Different Doses of Thalidomide in Experimentally Induced Inflammatory Bowel Disease in Rats

(2008) Om Prakash et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

(2008) G Stocco et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Efficacy of Intracolonic Administration of Low-Molecular-Weight Heparin CB-01-05, Compared to Other Low-Molecular-Weight Heparins and Unfractionated Heparin, in Experimentally Induced Colitis in Rat

(2008) Giuseppe Celasco et al.   DIGESTIVE DISEASES AND SCIENCES

Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines

(2008) A. Nakamura et al.   DRUG METABOLISM AND DISPOSITION

Modelling placebo response in depression trials using a longitudinal model with informative dropout

(2008) Roberto Gomeni et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Target-specific drug release to the colon

(2008) Sanjay K Jain et al.   Expert Opinion on Drug Delivery

Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease

(2008) M D Bhavsar et al.   GENE THERAPY

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

(2008) T Piche et al.   GUT

Local application of tacrolimus in distal colitis: Feasible and safe

(2008) Jolanda M. van Dieren et al.   INFLAMMATORY BOWEL DISEASES

Impairment of the in vitro drug release behaviour of oral modified release preparations in the presence of alcohol

(2008) Hala M. Fadda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: Ex vivo and in vivo studies

(2008) Akbar Bayat et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The gastrointestinal microbiota as a site for the biotransformation of drugs

(2008) Tiago Sousa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Gut instincts: Explorations in intestinal physiology and drug delivery

(2008) Emma L. McConnell et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man

(2008) Emma L. McConnell et al.   JOURNAL OF CONTROLLED RELEASE

A novel concept in enteric coating: A double-coating system providing rapid drug release in the proximal small intestine

(2008) Fang Liu et al.   JOURNAL OF CONTROLLED RELEASE

Microbiota-triggered colonic delivery: Robustness of the polysaccharide approach in the fed state in man

(2008) Abdul W. Basit et al.   JOURNAL OF DRUG TARGETING

The Molecular Interactions That Influence the Plasticizer Dependent Dissolution of Acrylic Polymer Films

(2008) Hala M. Fadda et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

An Investigation into the Digestion of Chitosan (Noncrosslinked and Crosslinked) by Human Colonic Bacteria

(2008) Emma L. McConnell et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

N,N′-Bis(5-aminosalicyl)-L-Cystine is a Potential Colon-specific 5-aminosalicylic Acid Prodrug with Dual Therapeutic Effects in Experimental Colitis

(2008) Heejung Kim et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial

(2008) Marc GH Besselink et al.   LANCET

Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial

(2008) Frank Buttgereit et al.   LANCET

Long-Term Safety and Impact on Infection Rates of Postnatal Probiotic and Prebiotic (Synbiotic) Treatment: Randomized, Double-Blind, Placebo-Controlled Trial

(2008) K. Kukkonen et al.   PEDIATRICS

Pharmacokinetics of the CYP 3A Substrate Simvastatin following Administration of Delayed Versus Immediate Release Oral Dosage Forms

(2008) Marija Tubic-Grozdanis et al.   PHARMACEUTICAL RESEARCH

Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems

(2008) Valentine C. Ibekwe et al.   PHARMACEUTICAL RESEARCH

Meal-Induced Acceleration of Tablet Transit Through the Human Small Intestine

(2008) Hala M. Fadda et al.   PHARMACEUTICAL RESEARCH

Polyethylene Glycol 400 Enhances the Bioavailability of a BCS Class III Drug (Ranitidine) in Male Subjects but Not Females

(2008) Diane A. I. Ashiru et al.   PHARMACEUTICAL RESEARCH

Rectal administration of d-alpha tocopherol for active ulcerative colitis: A preliminary report

(2008) Seyed Amir Mirbagheri et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Nicotine Enemas for Active Crohn's Colitis: An Open Pilot Study

(2008) J. R. Ingram et al.   Gastroenterology Research and Practice

Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update

(2007) Natalie L. Trevaskis et al.   ADVANCED DRUG DELIVERY REVIEWS

Circadian rhythms in arthritis: Hormonal effects on the immune/inflammatory reaction

(2007) Maurizio Cutolo et al.   AUTOIMMUNITY REVIEWS

Colonic antigen administration induces significantly higher humoral levels of colonic and vaginal IgA, and serum IgG compared to oral administration

(2007) Emma L. McConnell et al.   VACCINE