Review
Biochemistry & Molecular Biology
Verena Moosbrugger-Martinz, Corinne Leprince, Marie-Claire Mechin, Michel Simon, Stefan Blunder, Robert Gruber, Sandrine Dubrac
Summary: The discovery of loss-of-function mutations in the filaggrin gene has shed new light on the understanding of skin conditions such as ichthyosis vulgaris and atopic dermatitis. However, there is still much to learn about how filaggrin deficiency contributes to atopic dermatitis and the factors that lead to reduced filaggrin levels. This review re-evaluates the roles of filaggrin in the epidermis and atopic dermatitis, providing insights into its importance for keratinocyte alignment, maintenance of epidermal texture, and cellular abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Allergy
Haengdueng Jeong, Nakyum Lee, Chanyang Uhm, Kyungrae Cho, Heeju Oh, Yeseul Oh, KeLun Zhang, Hye Li Kim, James R. Goldenring, Kyung-Min Lim, Chang Ook Park, Ki Taek Nam
Summary: Rab-25 plays an important role in maintaining skin barrier function and keratinization in atopic dermatitis (AD).
Article
Allergy
Anna Maria Andersson, Julie Solberg, Anders Koch, Lone Skov, Ivone Jakasa, Sanja Kezic, Jacob Pontoppidan Thyssen
Summary: This study analyzed biomarkers in children with atopic dermatitis using tape strips and skin biopsies, finding that cytokine profiles in lesional skin were associated with disease severity, food allergy, and filaggrin gene mutations. Levels of TARC, CTACK, IL-8, and IL-18 in tape strips correlated significantly with AD severity, while skin biopsy data did not show significant correlations. Sampling the stratum corneum with non-invasive tape strips may be useful for identifying biomarkers associated with disease severity, food allergy, and filaggrin mutations.
Article
Medicine, General & Internal
Annalisa Astolfi, Francesca Cipriani, Daria Messelodi, Matilde De Luca, Valentina Indio, Costanza Di Chiara, Arianna Giannetti, Lorenza Ricci, Iria Neri, Annalisa Patrizi, Giampaolo Ricci, Andrea Pession
Summary: This study revealed that children with atopic dermatitis carrying FLG mutations are at higher risk of developing severe food allergies, such as anaphylaxis. Peanut and hazelnut were identified as high-risk foods for patients with FLG mutations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias, Sandrine Dubrac
Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Bum Soo Lee, Ye-Ryeong Cho, Minju Jeong, Yoon Seo Jang, Jin-Chul Kim, Sanguine Byun, Ki Hyun Kim
Summary: This study investigated the inhibitory effects of Cornus walteri on atopic dermatitis (AD). The results showed that Cornus walteri reduced the secretion of AD-related chemokines and upregulated filaggrin. Phytochemical analysis led to the identification of six potential bioactive constituents in Cornus walteri, and three of them significantly inhibited the expression of eotaxin-3. These findings suggest that Cornus walteri and its active compounds have potential as therapeutic agents for treating AD.
APPLIED SCIENCES-BASEL
(2022)
Article
Allergy
Tammy Gonzalez, Mariana L. Stevens, Asel Baatyrbek Kyzy, Rosario Alarcon, Hua He, John W. Kroner, Daniel Spagna, Brittany Grashel, Elaine Sidler, Lisa J. Martin, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey, Andrew B. Herr
Summary: In the first US early-life cohort of children with atopic dermatitis, the presence of staphylococcal biofilms on skin lesions was found to be associated with increased disease severity, suggesting a pathogenic role forS aureus biofilms in atopic dermatitis development. Additionally, the balance between S epidermidis and S aureus, as well as their biofilm propensity, may have important implications for atopic dermatitis.
Article
Biochemistry & Molecular Biology
Nahoko Zeze, Makiko Kido-Nakahara, Gaku Tsuji, Eriko Maehara, Yuki Sato, Sawako Sakai, Kei Fujishima, Akiko Hashimoto-Hachiya, Masutaka Furue, Takeshi Nakahara
Summary: Atopic dermatitis is a skin disorder characterized by inflammation, barrier disruption, and intense itch. This study investigates the involvement of the extracellular signal-regulated kinase (ERK) pathway in the pathogenesis of atopic dermatitis. The results suggest that the ERK pathway plays a role in the development of atopic dermatitis and may be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Hila Emmert, Hansjoerg Baurecht, Frederieke Thielking, Dora Stoelzl, Elke Rodriguez, Inken Harder, Ehrhardt Proksch, Stephan Weidinger
Summary: This study revealed significant differences in lipid composition between body sites and between AD patients and healthy individuals, as well as correlations between skin microbiome and skin lipid alterations in AD.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Veterinary Sciences
Rosanna Marsella, Kim Ahrens, Rachel Wilkes
Summary: Skin barrier dysfunction is important in atopic dermatitis and may be related to differences in cell growth behavior rather than tight junction protein differences. Atopic keratinocytes have lower TEER than normal keratinocytes, indicating higher epithelial permeability.
VETERINARY SCIENCES
(2022)
Review
Dermatology
Thomas Luger, Masayuki Amagai, Brigitte Dreno, Marie-Ange Dagnelie, Wilson Liao, Kenji Kabashima, Tamara Schikowski, Ehrhardt Proksch, Peter M. Elias, Michel Simon, Eric Simpson, Erin Grinich, Matthias Schmuth
Summary: AD is a chronic inflammatory skin disorder characterized by eczematous and pruritic skin lesions, with increasing prevalence worldwide in recent decades. Studies have shown that genetic defects affecting structural proteins of the skin barrier, as well as exposure to environmental allergens and pollutants, contribute to the development of AD. Research on epidermal barrier function, inflammation, lipid metabolism, and bacterial communities is crucial for understanding the complex etiology of AD and developing new therapies.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Immunology
Hyang Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong, Ji-Sook Lee, Yujin Hong, Beom Seok Park, Eun Ju Yang, In Sik Kim
Summary: Atopic dermatitis is a chronic disease characterized by skin inflammation and barrier dysfunction, with house dust mites being key allergens. A study on Der p 38, a novel mite allergen, has shown that it triggers atopic dermatitis by reducing skin barrier proteins and increasing inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tubanur Cetinarslan, Lisa Kuemper, Regina Foelster-Holst
Summary: Atopic dermatitis is a common and chronic inflammatory skin disease with various clinical presentations. The etiopathogenesis of AD involves structural and immunological epidermal barrier defect, imbalance of the skin microbiome, genetic background, and environmental factors. Therapeutic options targeting these pathways, such as topical steroids and biological therapies, have gained importance in the treatment of AD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Immunology
Natalija Novak, Leticia Tordesillas, Beatriz Cabanillas
Summary: The development of vaccines for COVID-19 began at the start of the pandemic and four vaccines have been authorized by international agencies. These vaccines have shown a significant decrease in infections and deaths, but rare adverse events have also been reported.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2022)
Editorial Material
Allergy
Beatriz Cabanillas, Natalija Novak, Cezmi A. Akdis
Review
Immunology
Natalija Novak, Leticia Tordesillas, Beatriz Cabanillas
Summary: T cells in the skin play a crucial role in immune surveillance and maintaining tissue homeostasis. Different subsets of T cells, including memory regulatory T cells, contribute to immune responses and skin pathologies. Non-classical T cells have also been shown to have a role in skin homeostasis, response to pathogens, as well as allergic skin inflammation and allergen sensitization.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Editorial Material
Allergy
Beatriz Cabanillas, Rafael Valdelvira, Cezmi A. Akdis
Editorial Material
Dermatology
Natalija Novak, Beatriz Cabanillas
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Dermatology
Beatriz Cabanillas
Summary: Dupilumab is the first approved targeted biological therapy for moderate-to-severe atopic dermatitis (AD), and it functions by blocking the downstream signaling of interleukin-4 and interleukin-13 receptors. The clinical improvements induced by dupilumab are associated with remission of dysregulated immune mechanisms and improved epidermal barrier defects in AD. This review provides an overview of the development of dupilumab, clinical trials in different age groups, outcomes, and reported adverse effects, as well as summarizing the current knowledge on its molecular and cellular mechanisms.
Article
Plant Sciences
Rafael Valdelvira, Guadalupe Garcia-Medina, Jesus F. Crespo, Beatriz Cabanillas
Summary: There is a growing interest in using legumes like lentil as healthy ingredients in gluten-free products. However, lentils are known to induce severe allergic reactions, and it is unclear whether lentil-based pasta retains the same allergenic potential as lentil seeds. This study found that alimentary lentil pasta has a significant allergenic content similar to lentil seeds. Boiling process also leads to the transfer of allergens from the food to boiling water. These findings highlight the importance of analyzing the allergenic content of new foods and ingredients introduced in traditional food products.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Review
Allergy
Beatriz Cabanillas, Giuseppe Murdaca, Amir Guemari, Maria Jose Torres, Ahmet Kursat Azkur, Emel Aksoy, Joana Vitte, Leticia de las Vecillas, Mattia Giovannini, Ruben Fernandez-Santamaria, Riccardo Castagnoli, Andrea Orsi, Rosa Amato, Irene Giberti, Alba Catala, Dominika Ambrozej, Bianca Schaub, Gerdien A. A. Tramper-Stranders, Natalija Novak, Kari C. C. Nadeau, Ioana Agache, Mubeccel Akdis, Cezmi A. A. Akdis
Summary: The current monkeypox disease outbreak is a new and significant threat to society, with over 55,000 confirmed cases in 103 countries. It is the largest and most serious outbreak since the initial diagnosis in 1970. While monkeypox is usually self-limiting, severe clinical manifestations and complications have been observed, particularly in vulnerable populations. The extensive spread of the current outbreak raises important questions that require investigation to better understand and prevent such threats in the future. A review addressing 50 questions about monkeypox virus and the current outbreak aims to provide up-to-date scientific information and explore the potential causes and consequences of this public health emergency.
Editorial Material
Allergy
Celine Galleani, Rafael Valdelvira, M. Carmen Dieguez, Jesus F. Crespo, Beatriz Cabanillas
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Letter
Allergy
Rafael Valdelvira, Guadalupe Garcia-Medina, Celine Galleani, Vera Kralova, Jesus F. F. Crespo, Beatriz Cabanillas
Review
Chemistry, Applied
Jesus F. Crespo, Beatriz Cabanillas
Summary: Food allergy is a growing public health issue, and recent research has shed light on the molecular and cellular mechanisms behind IgE-mediated food allergy. These discoveries have highlighted the important roles of specific cell types, such as T follicular helper cells, in the production of high-affinity IgE. Additionally, it has been found that not only mast cells and basophils, but also other cell types like neutrophils and macrophages, contribute to food anaphylaxis. Understanding the mechanisms of sensitization through organs like the skin is crucial for comprehending the dual exposure hypothesis and uncovering new approaches to anaphylaxis pathophysiology.
Article
Food Science & Technology
Carmen Cuadrado, Africa Sanchiz, Claudia Arribas, Mercedes M. Pedrosa, Pedro Gamboa, Diana Betancor, Carlos Blanco, Beatriz Cabanillas, Rosario Linacero
Summary: This study evaluates the allergenic features of peanuts after being subjected to heat, pressure, and enzymatic digestion. The combination of pressured heating treatments and enzymatic hydrolysis was found to be the most efficient method in reducing the allergenic potential of peanuts. These findings are important for patients who may undergo allergy treatment using processed peanuts, as well as for the food industry and regulatory agencies.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Allergy
Laura Marin, Beatriz Moya, Maria Jose Penalver, Beatriz Cabanillas, Ruth Barranco, Ismael Garcia-Moguel, Ruth Mielgo, Jesus Fernandez-Crespo
Summary: This study demonstrates that bedside meropenem allergy assessment in hospitalized patients with a labeled 'penicillin allergy' who require a broad-spectrum antibiotic for empiric coverage is a safe and effective procedure, avoiding the use of second-line antimicrobial agents.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Allergy
Christina M. Kronfel, Hsiaopo Cheng, Jane K. McBride, Jacqueline B. Nesbit, Rebecca Krouse, Preston Burns, Beatriz Cabanillas, Jesus F. Crespo, Robert Ryan, Reyna J. Simon, Soheila J. Maleki, Barry K. Hurlburt
Summary: The goal of this study is to determine the differences in allergic reactions between the US and Spain. It found that certain regions of Ara h 9, Jug r 3, and Pru p 3 are recognized more frequently by peanut-allergic individuals in the US, indicating potential cross-reactivity. These findings are important for the development of diagnostic and therapeutic tools for food allergies.
FRONTIERS IN ALLERGY
(2023)
Article
Chemistry, Applied
Rafael Valdelvira, Joana Costa, Jesus F. Crespo, Beatriz Cabanillas
Summary: This study investigated the impact of hydration on the release of major and minor allergens from peanut kernels. The results showed that hydration played a crucial role in the release of peanut allergens, with major allergen Ara h 1 being quickly released and minor allergens Ara h 8 and Ara h 9 diffusing into the water. The ratio of peanut to water and stirring had a significant impact on allergen release.
