Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

(2020) Hikari Tanaka et al.   Nature Communications

Dendrobium nobile Lindl Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity

(2020) Ling-Li Lv et al.   JOURNAL OF ALZHEIMERS DISEASE

Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway

(2019) Shiyu Gao et al.   Drug Design Development and Therapy

Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying mechanism

(2019) Sara Chavoshinezhad et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Distinct disease‐sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients

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Elevating acetyl-CoA levels reduces aspects of brain aging

(2019) Antonio Currais et al.   eLife

Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus

(2019) Fangyuan Yang et al.   Journal of Immunology Research

Is Alzheimer’s disease an inflammasomopathy?

(2019) Claudia F. Pereira et al.   AGEING RESEARCH REVIEWS

Honey is cytotoxic towards prostate cancer cells but interacts with the MTT reagent: Considerations for the choice of cell viability assay

(2018) Sean D.A. Abel et al.   FOOD CHEMISTRY

TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer's disease

(2018) Malihe Aminzadeh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury

(2018) Saifudeen Ismael et al.   JOURNAL OF NEUROTRAUMA

Dendritic Spine Abnormalities in Hippocampal CA1 Pyramidal Neurons Underlying Memory Deficits in the SAMP8 Mouse Model of Alzheimer's Disease

(2018) Jaume del Valle et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

(2017) Xinchun Ye et al.   EXPERIMENTAL NEUROLOGY

Factors underlying cognitive decline in old age and Alzheimer’s disease: the role of the hippocampus

(2017) Wafa Jaroudi et al.   REVIEWS IN THE NEUROSCIENCES

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction

(2017) Yi Zhang et al.   Cell Death & Disease

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

(2017) Annalisa Nobili et al.   Nature Communications

Early Amyloid Accumulation in the Hippocampus of SAMP8 Mice

(2017) Jaume del Valle et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons

(2016) Kumar Krishna et al.   JOURNAL OF ALZHEIMERS DISEASE

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals

(2016) Timothy M. Tucey et al.   mSphere

Gasdermin D: the long-awaited executioner of pyroptosis

(2015) Si Ming Man et al.   CELL RESEARCH

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability

(2015) Y. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Riluzole is a Promising Pharmacological Inhibitor of Bilirubin-Induced Excitotoxicity in the Ventral Cochlear Nucleus

(2014) Guo-Ying Han et al.   CNS Neuroscience & Therapeutics

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

(2013) Kumpei Tanisawa et al.   BMC GENOMICS

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

The Inflammasomes

(2010) Kate Schroder et al.   CELL

When neurogenesis encounters aging and disease

(2010) Orly Lazarov et al.   TRENDS IN NEUROSCIENCES

Amyloid Reduction by Amyloid-  Vaccination Also Reduces Mouse Tau Pathology and Protects from Neuron Loss in Two Mouse Models of Alzheimer's Disease

(2009) D. M. Wilcock et al.   JOURNAL OF NEUROSCIENCE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Cell death recognition model for the immune system

(2007) Erwei Sun   MEDICAL HYPOTHESES