Article
Gastroenterology & Hepatology
Arthur Mortha, Romain Remark, Diane Marie Del Valle, Ling-Shiang Chuang, Zhi Chai, Ines Alves, Catarina Azevedo, Joana Gaifem, Jerome Martin, Francesca Petralia, Kevin Tuballes, Vanessa Barcessat, Siu Ling Tai, Hsin-Hui Huang, Ilaria Laface, Yeray Arteaga Jerez, Gilles Boschetti, Nicole Villaverde, Mona D. Wang, Ujunwa M. Korie, Joseph Murray, Rok-Seon Choung, Takahiro Sato, Renee M. Laird, Scott Plevy, Adeeb Rahman, Joana Torres, Chad Porter, Mark S. Riddle, Ephraim Kenigsberg, Salome S. Pinho, Judy H. Cho, Miriam Merad, Jean-Frederic Colombel, Sacha Gnjatic
Summary: This study found that anti-granulocyte macrophage-colony stimulating factor autoantibodies (aGMAbs) can predict the diagnosis of complicated Crohn's disease (CD) long before the actual diagnosis. These antibodies recognize uniquely glycosylated epitopes, and their presence is associated with impaired immune balance and altered myeloid cell and innate lymphoid cell function.
Article
Microbiology
Gloria Griffante, Weronika Hewelt-Belka, Camilla Albano, Francesca Gugliesi, Selina Pasquero, Sergio Fernando Castillo Pacheco, Greta Bajetto, Paolo Ettore Porporato, Erica Mina, Marta Vallino, Christian Krapp, Martin Roelsgaard Jakobsen, John Purdy, Jens von Einem, Santo Landolfo, Valentina Dell'Oste, Matteo Biolatti
Summary: Human cytomegalovirus (HCMV) utilizes host cell resources for new virion assembly, including inducing cellular metabolism changes to favor virion production. However, the host defense factor IFI16 can counteract HCMV-induced metabolic reprogramming, limiting virion infectivity by downregulating glucose transporter 4 and reducing lipogenic enzyme transcription. This discovery unveils a potential target for novel antiviral therapies.
Article
Nutrition & Dietetics
Martyna Szczubelek, Karolina Pomorska, Monika Korolczyk-Kowalczyk, Konrad Lewandowski, Magdalena Kaniewska, Grazyna Rydzewska
Summary: Exclusive enteral nutrition (EEN) and Crohn's disease exclusion diet (CDED) are both effective in inducing remission in pediatric CD patients. The study demonstrates that CDED is equally effective in adult CD patients, with 76.7% achieving clinical remission after 6 weeks.
Review
Gastroenterology & Hepatology
Raja Atreya, Britta Siegmund
Summary: Crohn's disease can affect any part of the gastrointestinal tract, and research has shown distinct differences between ileal and colonic Crohn's disease. Colonic Crohn's disease behavior overlaps with ulcerative colitis, highlighting the need for a more comprehensive understanding of inflammatory bowel diseases. Location and shared pathophysiology subtypes play an important role in the classification of these diseases.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Immunology
Xue Fang, Le Kang, Yi-Fan Qiu, Zhao-Shen Li, Yu Bai
Summary: There is increasing focus on the roles of gut microbes in physiological and pathological processes. Crohn's disease (CD) is a chronic, relapsing, inflammatory disease of the gastrointestinal tract with unknown causes. Gastrointestinal infection, particularly Yersinia enterocolitica, has been suggested as a possible trigger for CD, although its specific role is still debated. This review discusses the current understanding of how Y. enterocolitica and its compounds may be involved in the development of CD, as well as potential interventions for diagnosis and treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Yu-Qing Lu, Jing Wu, Xiang-Ji Wu, Hui Ma, Yan-Xiu Ma, Rong Zhang, Meng-Nan Su, Nan Wu, Gong-Yin Chen, Hong-Song Chen, Xiao-Ben Pan
Summary: Research shows that IFI16 plays a role in sensing HBV infection and early changes in IFI16 mRNA in PBMCs can predict HBeAg seroconversion. Additionally, interferons can influence IFI16 degradation and subcellular location.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Rheumatology
Lihi Eder, Karen Tu, Cheryl F. Rosen, Raed Alhusayen, Stephanie Y. Cheng, Jacqueline Young, Willemina Campbell, Sasha Bernatsky, Dafna D. Gladman, J. Michael Paterson, Jessica Widdifield
Summary: The study found that health care utilization related to musculoskeletal issues increased significantly in PsA patients during the 5-year period prior to diagnosis. This suggests the existence of a prodromal phase in PsA characterized by nonspecific musculoskeletal symptoms, indicating the potential for earlier diagnosis.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Immunology
Yosuke Mai, Kentaro Izumi, Shoko Mai, Hideyuki Ujiie
Summary: Bullous pemphigoid (BP) is a common autoimmune blistering disease, and autoantibodies targeting BP180 and BP230 play a crucial role in BP pathogenesis. The detection of BP autoantibodies is important for diagnosis and disease monitoring. However, the detection of preclinical BP autoantibodies is still challenging. Previous studies have found that preclinical BP autoantibodies may be a potential risk factor for developing BP.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Giacomo Caio, Lisa Lungaro, Fabio Caputo, Eleonora Zoli, Fiorella Giancola, Giuseppe Chiarioni, Roberto De Giorgio, Giorgio Zoli
Summary: Crohn's disease is a chronic inflammatory bowel disease that can cause malnutrition in a significant percentage of patients, highlighting the importance of diet in managing the condition. This review aims to cover recent findings in nutrition for CD treatment, including established diets, new nutritional theories, and advancements in areas like nutrigenomics.
Article
Rheumatology
Yubin Luo, Yanli Tong, Liang Wu, Haitao Niu, Yanhong Li, Lin Chong Su, Yuxi Wu, Aline Bozec, Mario M. Zaiss, Pingying Qing, Hua Zhao, Chunyu Tan, Qiuping Zhang, Yi Zhao, Huairong Tang, Yi Liu
Summary: This study aims to investigate the gut microbiome and serum metabolic characteristics of individuals at high risk for rheumatoid arthritis (RA) and the causative effect of gut microbiome on the mucosal immune system and its involvement in the pathogenesis of arthritis. The results showed that the gut microbial composition differed between healthy controls and high-risk RA individuals, and there were significant differences in serum metabolites between the two groups. Fecal microbiota transplantation (FMT) from high-risk RA individuals triggered intestinal barrier dysfunction and changes in mucosal immunity, contributing to the development of arthritis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Congcong Liu, Ling Li, Gang Hou, Ying Lu, Meng Gao, Lianwen Zhang
Summary: This study identifies the abnormal expression of HERC5 in breast cancer cells and reveals its carcinogenic role through the HERC5/IFI16/p53 signaling pathway. The findings provide potential diagnostic and therapeutic biomarkers for breast cancer.
Article
Endocrinology & Metabolism
Christian Lundtoft, Daniel Eriksson, Matteo Bianchi, Maribel Aranda-Guillen, Nils Landegren, Solbritt Rantapaa-Dahlqvist, Peter Soderkvist, Jeniffer R. S. Meadows, DISSECT Consortium, Immunoarray Consortium, Swedish Addison Registry Study Grp, Gerli Rosengren Pielberg, Sophie Bensing, Gerli Rosengren Pielberg, Kerstin Lindblad-Toh, Lars Ronnblom, Olle Kampe
Summary: Autoantibodies against the adrenal enzyme 21-hydroxylase are a hallmark manifestation in autoimmune Addison's disease (AAD). This study identified strong associations between copy number variants in the CYP21 region and the risk of AAD, most likely due to linkage disequilibrium with disease-associated HLA class II alleles.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Gastroenterology & Hepatology
Giorgos Bamias, Fabio Cominelli
Summary: The development of Crohn's disease is characterized by a breakdown in the immune-bacterial communication, leading to a failure in mucosal defense mechanisms. This can result in a compromised epithelial barrier and dysregulated immune responses, ultimately causing chronic inflammation in the intestinal tissue. Understanding these cellular and molecular mechanisms may lead to targeted therapeutic approaches for treating CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adrian Martyniak, Andrzej Wedrychowicz, Przemyslaw J. Tomasik
Summary: Caring for patients with Crohn's disease is a serious challenge, and new methods of diagnosis and therapy are needed. Endogenous opioids, such as β-endorphin and proenkephalin (A), may have beneficial effects on the disease. This study found that the concentrations of these endo-opioids were reduced in CD patients, suggesting modulation of the endogenous opioid system as a promising future treatment for CD.
Editorial Material
Gastroenterology & Hepatology
Kim Isaacs, Sunanda Kane
Summary: With the increasing number of mechanisms of action for biologics in treating Crohn's disease, it can be challenging to compare agents without head-to-head trials. However, a comparative effectiveness methodology allows for indirect comparisons based on the outcome of interest, such as mucosal healing, to determine the best treatment for individual patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Dermatology
Cinzia Borgogna, Licia Martuscelli, Carlotta Olivero, Irene Lo Cigno, Marco De Andrea, Valeria Caneparo, Renzo Boldorini, Girish Patel, Marisa Gariglio
Summary: The combination of HPV infection, immune defects, and UVB exposure promotes skin cancer development.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Endocrinology & Metabolism
F. Prodam, M. Caputo, M. Romanisio, S. Brasili, M. Zavattaro, M. T. Sama, A. Ferrero, S. Costelli, F. R. Lenzi, A. Petri, E. Basso, S. Bellone, G. Aimaretti
Summary: This study evaluated the clinical and epidemiological characteristics of outpatients transitioning from Pediatric Endocrine Department to Adult Endocrine Department in a tertiary center, as well as the features of the transition process and predictors of drop-out. The findings showed that the patients were heterogeneous, with different ages, follow-up durations, and types of endocrine diseases. The number of visits was associated with the number and type of endocrine diseases, and adherence to follow-up was predicted by thyroid disorders and multiple comorbidities. A study exploring a specific transition plan for chronic endocrine diseases.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Pediatrics
Valentina Mancioppi, Valentina Antoniotti, Arianna Solito, Elisabetta Mingoia, Alice Monzani, Giulia Genoni, Ivana Rabbone, Flavia Prodam, Simonetta Bellone
Summary: This study investigated subclinical hypothyroidism in newborns and observed the changes in thyroid hormone levels over time until four years of age. The results showed that more than half of the newborns did not require treatment and had either normal or slightly increased thyroid function. The study also suggested the importance of long-term follow-up to monitor thyroid hormone levels.
Article
Dermatology
Angelo Valerio V. Marzano, Chiara Moltrasio, Giovanni Genovese, Marco De Andrea, Valeria Caneparo, Pamela Vezzoli, Denise Morotti, Paolo Sena, Marina Venturini, Simonetta Battocchio, Valentina Caputo, Nathalie Rizzo, Carlo Alberto Maronese, Luigia Venegoni, Francesca Laura Boggio, Franco Rongioletti, Piergiacomo Calzavara-Pinton, Emilio Berti
Summary: This study aimed to investigate the relationship between COVID-19 and skin manifestations, and found that SARS-CoV-2 was detected in only 38% of patients' skin samples. The research suggests that the occurrence of skin lesions mainly depends on the activation of the immune system, rather than a specific cutaneous phenotype.
Article
Gastroenterology & Hepatology
Marietta Iacucci, Tommaso Lorenzo Parigi, Rocio Del Amor, Pablo Meseguer, Giulio Mandelli, Anna Bozzola, Alina Bazarova, Pradeep Bhandari, Raf Bisschops, Silvio Danese, Gert De Hertogh, Jose G. Ferraz, Martin Goetz, Enrico Grisan, Xianyong Gui, Bu Hayee, Ralf Kiesslich, Mark Lazarey, Remo Panaccione, Adolfo Parra-Blanco, Luca Pastorelli, Timo Rath, Elin S. Royset, Gian Eugenio Tontini, Michael Vieth, Davide Zardo, Subrata Ghosh, Valery Naranjo, Vincenzo Villanacci
Summary: An artificial intelligence computer-aided diagnosis system was developed and validated to evaluate UC biopsies and predict prognosis. The system showed high accuracy and sensitivity in assessing biopsy results and predicting outcomes.
Article
Endocrinology & Metabolism
Cristina Partenope, Quincy Pedranzini, Antonella Petri, Ivana Rabbone, Flavia Prodam, Simonetta Bellone
Summary: The report presents a case of a 16-year-old boy who developed polyuria, polydipsia, and weight loss after receiving the COVID-19 vaccine. Diagnosis revealed neuroinfundibulohypophysitis, a rare disorder characterized by inflammation of the pituitary gland and stalk. Further studies are needed to explore the possible causal link between the COVID-19 vaccine and AVP deficiency.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Laura Francesca Pisani, Isabella Teani, Maurizio Vecchi, Luca Pastorelli
Summary: Accumulating evidence suggests that Interleukin-33 (IL-33) plays crucial roles in various aspects, including tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. It has been found to contribute to tumorigenesis and regulate angiogenesis and cancer progression in different types of human cancers. This review focuses on the basic biology and release mechanisms of IL-33 protein, as well as its involvement in the onset and progression of gastrointestinal cancer.
Article
Gastroenterology & Hepatology
Cristina Bezzio, Marta Vernero, Stefania Costa, Alessandro Armuzzi, Gionata Fiorino, Sandro Ardizzone, Jenny Roselli, Sonia Carparelli, Ambrogio Orlando, Flavio Andrea Caprioli, Fabiana Castiglione, Chiara Vigano, Davide Ribaldone, Fabiana Zingone, Rita Monterubbianesi, Nicola Imperatore, Stefano Festa, Marco Daperno, Ludovica Scucchi, Antonio Ferronato, Luca Pastorelli, Eleonora Alimenti, Paola Balestrieri, Chiara Ricci, Maria Cappello, Carla Felice, Francesca Coppini, Patrizia Alvisi, Imma Di Luna, Viviana Gerardi, Angela Variola, Silvia Mazzuoli, Marco Vincenzo Lenti, Simone Saibeni
Summary: This study compared the characteristics and outcomes of inflammatory bowel disease (IBD) patients with SARS-CoV-2 infection between the two pandemic waves in Italy. The patients in the first wave were older, more likely to have ulcerative colitis and comorbidities, and resided more frequently in Northern Italy. The rates of negative outcomes, such as pneumonia, hospital admission, ventilatory support, and death, were significantly higher in the first wave compared to the second wave.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Chiara Vigano, Andrea Palermo, Giacomo Mulinacci, Lorena Pirola, Alessandra Losco, Gianmichele Meucci, Simone Saibeni, Luca Pastorelli, Arnaldo Amato, Mario Gatti, Claudio Cortelezzi, Antonio Di Sabatino, Daniela Morganti, Francesca Boni, Gianalberto Grasso, Giovanni Casella, Valentina Casini, Flavio Andrea Caprioli, Maurizio Vecchi, Cristina Bezzio, Irene Bergna, Franco Radaelli, Caterina Mengoli, Sara Massironi
Summary: Disease-related malnutrition (DRM) is prevalent in inflammatory bowel disease (IBD) patients, with a rate of 23% and no significant difference between Crohn's disease and ulcerative colitis. DRM is associated with higher hospitalization rate, more frequent use of systemic steroids, lower levels of hemoglobin, albumin, prealbumin, and higher levels of C-reactive protein. Low BMI, current hospitalization, and hospitalization in the previous month are significantly associated with DRM.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Endocrinology & Metabolism
M. Caputo, T. Daffara, A. Ferrero, M. Romanisio, E. Monti, C. Mele, M. Zavattaro, S. Tricca, A. Siani, A. Clemente, C. Palumbo, S. De Cilla, A. Carriero, A. Volpe, P. Marzullo, G. Aimaretti, F. Prodam
Summary: The aim of this study was to identify risk factors for morphological changes in adrenal incidentalomas (AIs) during follow-up. High body weight, dehydroepiandrosterone sulfate (DHEAS), and direct renin concentration (DRC) were found to be associated with tumor enlargement, while aldosterone levels were lower in these cases. Additionally, glaucoma and dysglycemia had a higher prevalence in patients with tumor enlargement and were identified as independent predictors.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Martina Romanisio, Rosa Pitino, Alice Ferrero, Francesca Pizzolitto, Samuele Costelli, Valentina Antoniotti, Paolo Marzullo, Gianluca Aimaretti, Flavia Prodam, Marina Caputo
Summary: This study evaluated metabolic comorbidities in surgically treated acromegalic patients and found that the discrepancy between GH and IGF-1 levels does not appear to be a risk factor for their presence or persistence. Further extended studies are needed to confirm these results in the long term.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Valentina Mancioppi, Tommaso Daffara, Martina Romanisio, Giovanni Ceccarini, Caterina Pelosini, Ferruccio Santini, Simonetta Bellone, Simona Mellone, Alessio Baricich, Ivana Rabbone, Gianluca Aimaretti, Baris Akinci, Mara Giordano, Flavia Prodam
Summary: This article describes a rare lipodystrophy syndrome called congenital generalized lipodystrophy type 4 (CGL4), which is caused by mutations in the PTRF gene. Two early childhood patients presented with features such as reduced subcutaneous fat, muscular hypertrophy, distinctive facial features, myopathy, and atlantoaxial instability. Blood tests showed elevated CK and triglyceride levels, and undetectable leptin and adiponectin concentrations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Edda Cava, Daniele Spadaccini, Gianluca Aimaretti, Paolo Marzullo, Beatrice Cavigiolo, Deborah Farinelli, Alessandra Gennari, Chiara Saggia, Maria Grazia Carbonelli, Sergio Riso, Flavia Prodam
Summary: This retrospective observational cohort study aimed to assess the impact of a Mediterranean diet on weight and anthropometric changes in women completing active breast cancer treatment. The study found that implementing a Mediterranean diet can lead to weight and anthropometric improvements in breast cancer survivors. However, further research is necessary to explore the long-term effects of weight loss on these individuals and consider specific predictors of dropout.
Meeting Abstract
Gastroenterology & Hepatology
L. F. Pisani, G. Crespi, M. Mellai, C. Flavio, M. L. Annunziata, M. Manfredi, P. Luca, C. Porta
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Medicine, General & Internal
Guglielmo Albertini Petroni, Laura Francesca Pisani, Edoardo Borsotti, Maria Doria, Maria Laura Annunziata
Summary: This report describes the clinical efficacy and safety of vedolizumab in a patient with severe ulcerative colitis on haemodialysis. The patient had a severe flare-up of the disease and developed steroid dependence. Vedolizumab was used as maintenance therapy and was well tolerated without any adverse events.
SAGE OPEN MEDICAL CASE REPORTS
(2023)
