Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

Cyclin-dependent kinase 4 and 6 inhibitors for hormone receptor-positive breast cancer: past, present, and future

(2020) Laura M Spring et al.   LANCET

A UNIQUE CDK4/6 INHIBITOR: CURRENT AND FUTURE THERAPEUTIC STRATEGIES OF ABEMACICLIB

(2020) Qing-Yun Chong et al.   PHARMACOLOGICAL RESEARCH

Development of CDK2 and CDK5 Dual Degrader TMX‐2172

(2020) Nathanael Schiander Gray et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

(2020) Nadia Hégarat et al.   EMBO JOURNAL

Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis

(2020) Linda Viol et al.   JOURNAL OF CELL BIOLOGY

Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint

(2020) Mark Jackman et al.   JOURNAL OF CELL BIOLOGY

Separase-triggered apoptosis enforces minimal length of mitosis

(2020) Susanne Hellmuth et al.   NATURE

Temporal integration of mitogen history in mother cells controls proliferation of daughter cells

(2020) Mingwei Min et al.   SCIENCE

Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

(2019) Mingwei Min et al.   PLOS BIOLOGY

Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence

(2019) Jacob Peter Matson et al.   JOURNAL OF CELL BIOLOGY

Author Correction: An efficient auxin-inducible degron system with low basal degradation in human cells

(2019) Shiqian Li et al.   NATURE METHODS

Development of selective mono or dual PROTAC degrader probe of CDK isoforms

(2019) Fei Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

(2019) Keelan Z. Guiley et al.   SCIENCE

Surprising regulation of cell cycle entry

(2019) Charles J. Sherr   SCIENCE

Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

(2018) Miriam Bracha Ginzberg et al.   eLife

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation

(2018) Yumi Uetake et al.   MOLECULAR BIOLOGY OF THE CELL

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle

(2018) Steven D. Cappell et al.   NATURE

Control of the Restriction Point by Rb and p21

(2018) Justin Moser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway in KRAS-mutant non-small cell lung cancer

(2018) Eric Haines et al.   Oncotarget

Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway

(2018) Zhiqiang Li et al.   CANCER CELL

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

(2018) Scott Rata et al.   CURRENT BIOLOGY

Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle

(2017) Asako Sakaue-Sawano et al.   MOLECULAR CELL

Exit from quiescence displays a memory of cell growth and division

(2017) Xia Wang et al.   Nature Communications

Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

(2017) Tony Ly et al.   eLife

Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer

(2016) Maria Teresa Herrera-Abreu et al.   CANCER RESEARCH

Irreversible APC Cdh1 Inactivation Underlies the Point of No Return for Cell-Cycle Entry

(2016) Steven D. Cappell et al.   CELL

The ubiquitin ligase CRL2 ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage

(2016) Riju S. Balachandran et al.   JOURNAL OF CELL BIOLOGY

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

(2016) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

(2016) Franz Meitinger et al.   JOURNAL OF CELL BIOLOGY

Identification and Characterization of an Irreversible Inhibitor of CDK2

(2015) Elizabeth Anscombe et al.   CHEMISTRY & BIOLOGY

Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6

(2015) E. K. Ziemke et al.   CLINICAL CANCER RESEARCH

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

Brk/Protein Tyrosine Kinase 6 Phosphorylates p27KIP1, Regulating the Activity of Cyclin D–Cyclin-Dependent Kinase 4

(2015) Priyank Patel et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting CDK4 and CDK6: From Discovery to Therapy

(2015) C. J. Sherr et al.   Cancer Discovery

Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells

(2015) Tony Ly et al.   eLife

Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS

(2015) Barbie Taylor-Harding et al.   Oncotarget

A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells

(2014) Tony Ly et al.   eLife

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

(2014) Anil M Narasimha et al.   eLife

The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit

(2013) Sabrina L. Spencer et al.   CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell Cycle-Based Therapies Move Forward

(2012) Marcos Malumbres   CANCER CELL

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation

(2011) Karl A. Merrick et al.   MOLECULAR CELL

Quantitative Proteomics Reveals the Basis for the Biochemical Specificity of the Cell-Cycle Machinery

(2011) Felicia Walton Pagliuca et al.   MOLECULAR CELL

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

A Bifunctional Regulatory Element in Human Somatic Wee1 Mediates Cyclin A/Cdk2 Binding and Crm1-Dependent Nuclear Export

(2009) C. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Phosphorylation of p27Kip1 Regulates Assembly and Activation of Cyclin D1-Cdk4

(2008) M. D. Larrea et al.   MOLECULAR AND CELLULAR BIOLOGY