Specific and direct modulation of the interaction between adhesion GPCR GPR56/ADGRG1 and tissue transglutaminase 2 using synthetic ligands

GPR56/ADGRG1 is associated with response to antidepressant treatment

(2020) Raoul Belzeaux et al.   Nature Communications

Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56

(2019) Tomoya Kitakaze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

GAIN domain–mediated cleavage is required for activation of G protein–coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist

(2019) Beika Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia

(2019) Abdelrahman H. Elsayed et al.   LEUKEMIA

The role of transglutaminase 2 in mediating glial cell function and pathophysiology in the central nervous system

(2019) Jacob Rudlong et al.   ANALYTICAL BIOCHEMISTRY

Adhesion G Protein–Coupled Receptors as Drug Targets

(2018) Ryan H. Purcell et al.   Annual Review of Pharmacology and Toxicology

Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse

(2018) Jingxian Li et al.   CELL

The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function

(2018) Oladapo E. Olaniru et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

(2018) Stefanie Giera et al.   eLife

The Adhesion G-Protein-Coupled Receptor, GPR56/ADGRG1, Inhibits Cell–Extracellular Matrix Signaling to Prevent Metastatic Melanoma Growth

(2018) Michelle W. Millar et al.   Frontiers in Oncology

Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV)

(2018) James S. Lawson et al.   Frontiers in Oncology

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling

(2017) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region

(2017) Gabriel S. Salzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular and preclinical comparison of the PD-1–targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab

(2017) Petros Fessas et al.   SEMINARS IN ONCOLOGY

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

(2016) C. Pabst et al.   BLOOD

Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility

(2016) Nien-Yi Chiang et al.   JOURNAL OF CELL SCIENCE

Adhesion G Protein-Coupled Receptor G1 (ADGRG1/GPR56) and Pancreatic β-Cell Function

(2016) Pontus Dunér et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adhesion G protein-coupled receptors in nervous system development and disease

(2016) Tobias Langenhan et al.   NATURE REVIEWS NEUROSCIENCE

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells

(2016) Gin-Wen Chang et al.   Cell Reports

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

(2015) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

(2015) Yue C. Lu et al.   STRUCTURE

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

(2015) Stefanie Giera et al.   Nature Communications

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA

(2015) Sarah D. Ackerman et al.   Nature Communications

Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis

(2014) N. Ozlu et al.   EMBO JOURNAL

Transglutaminase Regulation of Cell Function

(2014) Richard L. Eckert et al.   PHYSIOLOGICAL REVIEWS

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

(2014) J. P. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

GPR56 Inhibits Melanoma Growth by Internalizing and Degrading Its Ligand TG2

(2013) L. Yang et al.   CANCER RESEARCH

Pertuzumab: Optimizing HER2 Blockade

(2013) O. Metzger-Filho et al.   CLINICAL CANCER RESEARCH

G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle developmentin vivo

(2013) Melissa P. Wu et al.   FEBS Journal

ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function

(2013) Gershon Celniker et al.   ISRAEL JOURNAL OF CHEMISTRY

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins

(2013) Simone Prömel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

TG2, a novel extracellular protein with multiple functions

(2011) Zhuo Wang et al.   AMINO ACIDS

GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression

(2011) L. Yang et al.   CANCER RESEARCH

The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity

(2011) Kevin J. Paavola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific expression of GPR56 by human cytotoxic lymphocytes

(2011) Yen-Ming Peng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins

(2011) M. F. Bolliger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacology of TNF blockade in rheumatoid arthritis and other chronic inflammatory diseases

(2010) Peter C Taylor   CURRENT OPINION IN PHARMACOLOGY

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

(2010) H. Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation

(2010) Dorothy Beckett et al.   PROTEIN SCIENCE

Adhesion-GPCRs: emerging roles for novel receptors

(2008) Simon Yona et al.   TRENDS IN BIOCHEMICAL SCIENCES