Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 20, Pages 5439-5442Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.09.023
Keywords
allosteric; agonist; TBPB; muscarinic receptor
Categories
Funding
- NIH
- NIMH [1RO1MH082867-01]
- Vanderbilt Institute of Chemical Biology Pilot Project
- Alzheimer's Association [IIRG-07-57131]
- ITTD [T90-DA022873]
- National Research Service [1FM32 MH079678-01]
Ask authors/readers for more resources
This Letter describes the first account of the synthesis and SAR, developed through an iterative analogue library approach, of analogues of the highly selective M1 allosteric agonist TBPB. With slight structural changes, mAChR selectivity was maintained, but the degree of partial M1 agonism varied considerably. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available