Thiopurines in Pediatric Inflammatory Bowel Disease: Current and Future Place
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Thiopurines in Pediatric Inflammatory Bowel Disease: Current and Future Place
Authors
Keywords
-
Journal
PEDIATRIC DRUGS
Volume 22, Issue 5, Pages 449-461
Publisher
Springer Science and Business Media LLC
Online
2020-08-14
DOI
10.1007/s40272-020-00411-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Efficacy, pharmacokinetics and immunogenicity is not affected by switching from infliximab originator to a biosimilar in pediatric patients with inflammatory bowel disease.
- (2019) Karen van Hoeve et al. THERAPEUTIC DRUG MONITORING
- Long-term outcome of immunomodulator use in pediatric patients with inflammatory bowel disease
- (2019) Karen van Hoeve et al. DIGESTIVE AND LIVER DISEASE
- Vaccinations and Immunization Status in Pediatric Inflammatory Bowel Disease: A Multicenter Study From the Pediatric IBD Porto Group of the ESPGHAN
- (2019) Massimo Martinelli et al. INFLAMMATORY BOWEL DISEASES
- The Role of Thiopurines in Pediatric Inflammatory Bowel Diseases
- (2019) Ohad Atia et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Combination Therapy of Adalimumab With an Immunomodulator Is Not More Effective Than Adalimumab Monotherapy in Children With Crohn’s Disease: A Post Hoc Analysis of the PAILOT Randomized Controlled Trial
- (2019) Manar Matar et al. INFLAMMATORY BOWEL DISEASES
- Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN
- (2018) M. E. Joosse et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Does Azathioprine induce endoscopic and histologic healing in pediatric inflammatory bowel disease? A prospective, observational study
- (2018) Francesca Paola Giugliano et al. DIGESTIVE AND LIVER DISEASE
- Accelerated Step-Up Infliximab Use Is Associated with Sustained Primary Response in Pediatric Crohn’s Disease
- (2018) J. Ling et al. DIGESTIVE DISEASES AND SCIENCES
- Frequency and type of drug-related side effects necessitating treatment discontinuation in the Swiss Inflammatory Bowel Disease Cohort
- (2018) Sébastien Godat et al. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
- The Impact of Thiopurine Metabolite Monitoring on the Durability of Thiopurine Monotherapy in Pediatric IBD
- (2018) Elizabeth Spencer et al. INFLAMMATORY BOWEL DISEASES
- Management of Paediatric Ulcerative Colitis, Part 2
- (2018) Dan Turner et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Management of Paediatric Ulcerative Colitis, Part 1
- (2018) Dan Turner et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Thiopurine Optimization Through Combination With Allopurinol in Children With Inflammatory Bowel Diseases
- (2018) Mark R. Serpico et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Current global trends in the incidence of pediatric-onset inflammatory bowel disease
- (2018) Josef Sýkora et al. WORLD JOURNAL OF GASTROENTEROLOGY
- The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World
- (2018) Peter C. Church et al. Canadian Journal of Gastroenterology and Hepatology
- The effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in paediatric patients with Crohn’s disease: a post hoc analysis
- (2018) Jeffrey S. Hyams et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Exclusive enteral nutrition with concomitant early thiopurine use was effective in maintaining steroid-free remission in a Southeast Asian cohort of children with Crohn’s disease
- (2018) Christina Ong et al. BMC GASTROENTEROLOGY
- Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update
- (2018) Mary V. Relling et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Therapeutic drug monitoring of anti-TNF therapy in children with inflammatory bowel disease
- (2017) Karen van Hoeve et al. Expert Opinion On Drug Safety
- Infliximab Is Not Associated With Increased Risk of Malignancy or Hemophagocytic Lymphohistiocytosis in Pediatric Patients With Inflammatory Bowel Disease
- (2017) Jeffrey S. Hyams et al. GASTROENTEROLOGY
- Multicentric Case–Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease
- (2017) Gabriele Stocco et al. INFLAMMATORY BOWEL DISEASES
- Higher Thioguanine Nucleotide Metabolite Levels are Associated With Better Long-term Outcomes in Patients With Inflammatory Bowel Diseases
- (2017) Andres J. Yarur et al. JOURNAL OF CLINICAL GASTROENTEROLOGY
- Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives
- (2017) Nanne K H de Boer et al. Journal of Crohns & Colitis
- Less Anti-infliximab Antibody Formation in Paediatric Crohn Patients on Concomitant Immunomodulators
- (2017) Hannah M. Kansen et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study
- (2017) Subra Kugathasan et al. LANCET
- Therapeutic Drug Monitoring in Inflammatory Bowel Disease
- (2017) Elizabeth A. Spencer et al. PEDIATRIC CLINICS OF NORTH AMERICA
- Treatment of perianal Crohn’s disease
- (2017) Jill M. Zalieckas Seminars in Pediatric Surgery
- Analytical Pitfalls of Therapeutic Drug Monitoring of Thiopurines in Patients With Inflammatory Bowel Disease
- (2017) Melek Simsek et al. THERAPEUTIC DRUG MONITORING
- Novel Targeted Therapies for Inflammatory Bowel Disease
- (2017) Mehmet Coskun et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease
- (2016) X. Zhu et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Pharmacokinetic Features and Presence of Antidrug Antibodies Associate With Response to Infliximab Induction Therapy in Patients With Moderate to Severe Ulcerative Colitis
- (2016) Johannan F. Brandse et al. Clinical Gastroenterology and Hepatology
- Effect of Early Versus Late Azathioprine Therapy in Pediatric Ulcerative Colitis
- (2016) Marina Aloi et al. INFLAMMATORY BOWEL DISEASES
- Adalimumab Monotherapy and a Combination with Azathioprine for Crohn’s Disease: A Prospective, Randomized Trial
- (2016) Takayuki Matsumoto et al. Journal of Crohns & Colitis
- Mucosal Healing in Paediatric Patients with Moderate-to-Severe Luminal Crohn’s Disease Under Combined Immunosuppression: Escalation versus Early Treatment
- (2016) Ben Kang et al. Journal of Crohns & Colitis
- Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease
- (2016) Dennis R. Wong et al. Journal of Crohns & Colitis
- Thiopurine metabolite testing in inflammatory bowel disease
- (2016) Rimma Goldberg et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- EBV Status and Thiopurine Use in Pediatric IBD
- (2016) Julia Gordon et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
- (2016) Takaya Moriyama et al. NATURE GENETICS
- Impact of early thiopurines on surgery in 2770 children and young people diagnosed with inflammatory bowel disease: a national population-based study
- (2015) V. Chhaya et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target
- (2015) L Peyrin-Biroulet et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Withdrawal of Immunomodulators After Co-treatment Does Not Reduce Trough Level of Infliximab in Patients With Crohn’s Disease
- (2015) David Drobne et al. Clinical Gastroenterology and Hepatology
- Seroprevalence of Epstein–Barr Virus, Cytomegalovirus, and Polyomaviruses in Children with Inflammatory Bowel Disease
- (2015) Ondrej Hradsky et al. DIGESTIVE DISEASES AND SCIENCES
- Antibodies to Infliximab Are Associated with Lower Infliximab Levels and Increased Likelihood of Surgery in Pediatric IBD
- (2015) Naamah L. Zitomersky et al. INFLAMMATORY BOWEL DISEASES
- InheritedNUDT15Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia
- (2015) Jun J. Yang et al. JOURNAL OF CLINICAL ONCOLOGY
- Successful Mercaptopurine Usage despite Azathioprine-Induced Pancreatitis in Paediatric Crohn’s Disease
- (2015) Silvia Gallego-Gutiérrez et al. Journal of Crohns & Colitis
- Inflammatory Bowel Disease and Pancreatitis: A Review
- (2015) Lídia Roque Ramos et al. Journal of Crohns & Colitis
- Safety Profile of Thiopurines in Crohn Disease
- (2015) Yun Qiu et al. MEDICINE
- Epidemiology and risk factors for IBD
- (2015) Ashwin N. Ananthakrishnan Nature Reviews Gastroenterology & Hepatology
- Letter: azathioprine-induced pancreatitis and subsequent tolerance of mercaptopurine
- (2014) L. Beswick et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Thiopurine monitoring in children with inflammatory bowel disease: a systematic review
- (2014) Anastasia Konidari et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Catching the Therapeutic Window of Opportunity in Early Crohn’s Disease
- (2014) Silvio Danese et al. CURRENT DRUG TARGETS
- Early Use of Thiopurines or Methotrexate Reduces Major Abdominal and Perianal Surgery in Crohnʼs Disease
- (2014) Viraj C. Kariyawasam et al. INFLAMMATORY BOWEL DISEASES
- Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease
- (2014) F.M. Ruemmele et al. Journal of Crohns & Colitis
- Thiopurine Metabolite Ratios for Monitoring Therapy in Pediatric Crohn Disease
- (2014) U. Kopylov et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia
- (2014) Suk-Kyun Yang et al. NATURE GENETICS
- Early anti-TNF treatment in pediatric Crohn’s disease. Predictors of clinical outcome in a population-based cohort of newly diagnosed patients
- (2014) Christine Olbjørn et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Randomised clinical trial: individualised vs. weight-based dosing of azathioprine in Crohn's disease
- (2013) T. Dassopoulos et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Implementation of TPMT testing
- (2013) Lynne Lennard BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation
- (2013) Martin Mynarek et al. Clinical & Developmental Immunology
- Increased Effectiveness of Early Therapy With Anti-Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease
- (2013) Thomas D. Walters et al. GASTROENTEROLOGY
- Exploring Associations of 6-Thioguanine Nucleotide Levels and Other Predictive Factors with Therapeutic Response to Azathioprine in Pediatric Patients with IBD Using Multilevel Analysis
- (2013) Thi-Van-Anh Nguyen et al. INFLAMMATORY BOWEL DISEASES
- Safety of Thiopurine Therapy in Inflammatory Bowel Disease
- (2013) María Chaparro et al. INFLAMMATORY BOWEL DISEASES
- Usefulness of Thiopurine Metabolites in Predicting Azathioprine Resistance in Pediatric IBD Patients
- (2013) Thi-Van-Anh Nguyen et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Are Thiopurines Always Contraindicated After Thiopurine-Induced Pancreatitis in Inflammatory Bowel Disease?
- (2013) Oren D. Ledder et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Nomenclature for alleles of the thiopurine methyltransferase gene
- (2013) Malin L. Appell et al. Pharmacogenetics and Genomics
- Use of thiopurines in inflammatory bowel disease
- (2013) Pascal Frei WORLD JOURNAL OF GASTROENTEROLOGY
- Letter: successful mercaptopurine therapy after azathioprine-related pancreatitis in patients with IBD
- (2012) L. Beswick et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism
- (2012) D. Q. Shih et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- The impact of introducing thioguanine nucleotide monitoring into an inflammatory bowel disease clinic
- (2012) M. Smith et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine
- (2011) L. Armstrong et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- The changing pattern of Crohn’s disease incidence in northern France: a continuing increase in the 10- to 19-year-old age bracket (1988-2007)
- (2011) V. Chouraki et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Outcome Following Thiopurine Use in Children With Ulcerative Colitis: A Prospective Multicenter Registry Study
- (2011) Jeffrey S Hyams et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Tolerance and efficacy of azathioprine in pediatric Crohnʼs disease
- (2011) Laura Riello et al. INFLAMMATORY BOWEL DISEASES
- Pediatric inflammatory bowel disease: Increasing incidence, decreasing surgery rate, and compromised nutritional status: A prospective population-based cohort study 2007–2009
- (2011) Christian Jakobsen et al. INFLAMMATORY BOWEL DISEASES
- Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function
- (2011) Ulf Hindorf et al. Journal of Crohns & Colitis
- Thiopurine treatment in inflammatory bowel disease: Response predictors, safety, and withdrawal in follow-up
- (2011) Giuseppe Costantino et al. Journal of Crohns & Colitis
- Do Children With IBD Really Respond Better Than Adults to Thiopurines?
- (2011) JR Goodhand et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Genetics and pathogenesis of inflammatory bowel disease
- (2011) Bernard Khor et al. NATURE
- Infliximab therapy in children with Crohn’s disease: a one-year evaluation of efficacy comparing ‘top-down’ and ‘step-up’ strategies
- (2010) Mi Jin Kim et al. ACTA PAEDIATRICA
- Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy
- (2010) P de Graaf et al. BRITISH JOURNAL OF PHARMACOLOGY
- Severe Pediatric Ulcerative Colitis: A Prospective Multicenter Study of Outcomes and Predictors of Response
- (2010) Dan Turner et al. GASTROENTEROLOGY
- Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts
- (2010) B. Jharap et al. INFLAMMATORY BOWEL DISEASES
- Steroid dependency and pediatric inflammatory bowel disease in the era of immunomodulators—A population-based study
- (2010) Christian Jakobsen et al. INFLAMMATORY BOWEL DISEASES
- Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends
- (2010) Eric I. Benchimol et al. INFLAMMATORY BOWEL DISEASES
- Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come
- (2010) L. T. Ford et al. JOURNAL OF CLINICAL PATHOLOGY
- A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine
- (2010) Mark E. Gerich et al. Journal of Crohns & Colitis
- Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease
- (2010) Jean Frédéric Colombel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutagenicity and Potential Carcinogenicity of Thiopurine Treatment in Patients with Inflammatory Bowel Disease
- (2009) T. Nguyen et al. CANCER RESEARCH
- Azathioprine induced pneumonitis in a patient with ulcerative colitis
- (2009) Alexander G.L. Bodelier et al. Journal of Crohns & Colitis
- Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
- (2009) Laurent Beaugerie et al. LANCET
- Evolving Inflammatory Bowel Disease Treatment Paradigms: Top-Down Versus Step-Up
- (2009) Shane M. Devlin et al. MEDICAL CLINICS OF NORTH AMERICA
- Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease
- (2008) U. HINDORF et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Thiopurine-Induced Myelotoxicity in Patients With Inflammatory Bowel Disease: A Review
- (2008) Javier P. Gisbert et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Withdrawal of Immunosuppression in Crohn's Disease Treated With Scheduled Infliximab Maintenance: A Randomized Trial
- (2008) Gert Van Assche et al. GASTROENTEROLOGY
- Effect of early immunomodulator use in moderate to severe pediatric Crohn disease
- (2008) Jaya Punati et al. INFLAMMATORY BOWEL DISEASES
- Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease
- (2008) Riad M. Rahhal et al. INFLAMMATORY BOWEL DISEASES
- Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger
- (2008) Andrew B. Grossman et al. INFLAMMATORY BOWEL DISEASES
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started