Article
Pediatrics
Tereza Lerchova, Ondrej Hradsky, Michal Kulich, Gabor Veres, Jorge Amil Dias, Malgorzata Sladek, Sanja Kolacek, Stephanie Van Biervliet, Jan Melek, Daniela E. Serban, Katrine Winther, Tim de Meij, Jan Schwarz, Kaija-Leena Kolho, Johanna C. Escher, Jiri Bronsky
Summary: This study developed a predictive model based on six baseline parameters to potentially predict early azathioprine treatment failure in pediatric CD patients. A web-based tool has been created to estimate individual relapse risk in pediatric CD patients on a particular therapeutic regimen.
PEDIATRIC RESEARCH
(2023)
Article
Health Care Sciences & Services
Sarahi Valdez-Acosta, Pablo Zubiaur, Miguel Angel Casado, Jesus Novalbos, Ana Casajus, Diana Campodonico, Itziar Oyaguez, Francisco Abad-Santos
Summary: A cost analysis of thiopurine treatment in 257 patients showed that preemptive genotyping and physician adherence to genotype-informed therapeutic recommendations significantly reduced healthcare costs and prevented myelotoxicity. Patients retrospectively genotyped had higher healthcare costs compared to preemptively genotyped patients. Intermediate metabolizers had significantly higher healthcare costs compared to normal metabolizers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
M. Effenberger, S. Reider, S. Waschina, C. Bronowski, B. Enrich, T. E. Adolph, R. Koch, A. R. Moschen, P. Rosenstiel, K. Aden, H. Tilg
Summary: Longitudinal microbiome changes in IBD patients undergoing therapy with either azathioprine or anti-TNF antibodies showed significant alterations in microbial community composition under specific therapies, with a notable increase in butyrate production capacity in patients in remission.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, General & Internal
Gerard Grau, Eduard Brunet-Mas, Laura Patricia Llovet, Patricia Pedregal, Albert Villoria, Luigi Melcarne, Anna Puy, Belen Garcia-Sague, Luis Enrique Frisancho, Maria Jose Ramirez-Lazaro, Sergio Lario, Xavier Calvet
Summary: Thiopurines are a safe and effective treatment for maintaining remission in inflammatory bowel disease, with minimal adverse effects, especially after the first few months of treatment. This study suggests that regular analytic follow-up may not be necessary after the initial period of treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Keita Kawakado, Kazuhisa Nakashima, Hiroshi Tobita, Mamiko Nagase, Ken Yoshihara, Mika Horie, Megumi Hamaguchi, Tamio Okimoto, Yukari Tsubata, Takeshi Isobe
Summary: An 82-year-old man with malignant pleural mesothelioma was treated with ipilimumab and nivolumab. Despite previous treatment with prednisolone for immune-related adverse event hepatitis, his liver function worsened. After trying different medications, a combination of mercaptopurine and prednisolone improved his liver function and allowed for the gradual reduction of prednisolone dose. This case highlights the potential effectiveness of thiopurine-based immunosuppressants for steroid-refractory hepatitis.
Article
Gastroenterology & Hepatology
Cumali Efe, Craig Lammert, Koray Tascilar, Renumathy Dhanasekaran, Berat Ebik, Fatima Higuera-de la Tijera, Ali R. Caliskan, Mirta Peralta, Alessio Gerussi, Hatef Massoumi, Andreea M. Catana, Tugrul Purnak, Cristina Rigamonti, Andres J. G. Aldana, Nidah Khakoo, Leyla Nazal, Shalom Frager, Nurhan Demir, Kader Irak, Zeynep Melekoglu-Ellik, Huseyin Kacmaz, Yasemin Balaban, Kadri Atay, Fatih Eren, Mario R. Alvares-da-Silva, Laura Cristoferi, Alvaro Urzua, Tugce Eskazan, Bianca Magro, Romee Snijders, Sezgin Barutcu, Ellina Lytvyak, Godolfino M. Zazueta, Aylin Demirezer-Bolat, Mesut Aydin, Alexandra Heurgue-Berlot, Eleonora De Martin, Nazim Ekin, Sumeyra Yildirim, Ahmet Yavuz, Murat Biyik, Graciela C. Narro, Murat Kiyici, Murat Akyildiz, Evrim Kahramanoglu-Aksoy, Maria Vincent, Rotonya M. Carr, Fulya Gunsar, Eira C. Reyes, Murat Harputluoglu, Costica Aloman, Nikolaos K. Gatselis, Yucel Ustundag, Javier Brahm, Nataly C. E. Vargas, Fatih Guzelbulut, Sandro R. Garcia, Jonathan Aguirre, Margarita Anders, Natalia Ratusnu, Ibrahim Hatemi, Manuel Mendizabal, Annarosa Floreani, Stefano Fagiuoli, Marcelo Silva, Ramazan Idilman, Sanjaya K. Satapathy, Marina Silveira, Joost P. H. Drenth, George N. Dalekos, David N. Assis, Einar Bjornsson, James L. Boyer, Eric M. Yoshida, Pietro Invernizzi, Cynthia Levy, Aldo J. Montano-Loza, Thomas D. Schiano, Ezequiel Ridruejo, Staffan Wahlin
Summary: The study found that AIH patients who were on systemic glucocorticoids or thiopurines before the onset of COVID-19 had significantly worse severity of the disease, while those on baseline treatment with mycophenolate mofetil or tacrolimus also experienced more severe COVID-19 courses in a smaller subset of treated patients.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Daniel Rehling, Si Min Zhang, Ann-Sofie Jemth, Tobias Koolmeister, Adam Throup, Olov Wallner, Emma Scaletti, Takaya Moriyama, Rina Nishii, Jonathan Davies, Matthieu Desroses, Sean G. Rudd, Martin Scobie, Evert Homan, Ulrika Warpman Berglund, Jun J. Yang, Thomas Helleday, Pal Stenmark
Summary: The newly discovered NUDT15 inhibitor TH7755 has shown improved potency and specificity compared to TH1760, enhancing the effects of thiopurines without causing cytotoxicity. This potent inhibitor also stabilized NUDT15, allowing for analysis by X-ray crystallography to provide insights into the structural basis for thiopurine intolerance in patients with pharmacogenetic variants.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Abhinav Vasudevan, Danny Con, Peter De Cruz, Miles P. Sparrow, Antony B. Friedman, Mayur Garg, Soleiman Kashkooli, Peter R. Gibson, Daniel R. van Langenberg
Summary: This study compared the use of thiopurine-allopurinol combination therapy with standard thiopurine therapy in IBD. The results showed that the thiopurine-allopurinol group had better outcomes in the primary efficacy assessment, fewer adverse events, and less frequent thiopurine dose adjustments.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Vilja Koskensalo, Pasi Aronen, Martti Farkkila, Leena Kylanpaa, Outi Lindstrom, Mia Rainio, Marianne Udd, Kalle Jokelainen, Andrea Tenca
Summary: The study did not find that prior or current use of thiopurines increases the risk of post-ERCP pancreatitis in patients with PSC.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Medical Laboratory Technology
Sofia A. W. van Moorsel, Debbie S. Deben, Rob H. Creemers, Bjorn Winkens, Paul Bus, Marieke J. Pierik, Melek Simsek, Nanne K. H. de Boer, Adriaan A. van Bodegraven, Dennis R. Wong
Summary: This study aimed to validate and optimize predictive algorithms for thiopurine-associated hepatotoxicity, but found limited accuracy in predicting liver toxicity. Factors contributing to this outcome included changes in prescription behavior over time and lower dosages of MP being prescribed.
THERAPEUTIC DRUG MONITORING
(2022)
Article
Gastroenterology & Hepatology
C. Jorissen, B. Verstockt, N. Schils, J. Sabino, M. Ferrante, S. Vermeire
Summary: Discontinuation of thiopurines in elderly IBD patients in clinical and/or endoscopic remission results in sustained clinical remission in two-thirds of patients. Patients who flare can mostly be rescued with biologicals although one-third necessitate surgery. A significant proportion of patients developed malignancies under but also after thiopurines discontinuation, indicating that these patients necessitate a continued close follow-up. Decision-making in this vulnerable subgroup of patients remains difficult.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Patrick Chan, Susan Connor, Vivian Huang, Neda Karimi, Astrid-Jane Williams
Summary: This article is connected to the paper by Zisman-Ilani et al. The paper can be viewed by visiting the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Maia Kayal, Alexa Riggs, Michael Plietz, Sergey Khaitov, Patricia Sylla, Alexander J. Greenstein, Noam Harpaz, Steven H. Itzkowitz, Shailja C. Shah
Summary: Thiopurine exposure for at least 12 weeks prior to TPC in patients with UC or IC does not appear to be independently associated with the risk of primary neoplasia following IPAA.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Ashkan Rezazadeh Ardabili, Steven Jeuring, Zlatan Mujagic, Liekele Oostenbrug, Marielle Romberg-Camps, Daisy Jonkers, Adriaan van Bodegraven, Marieke Pierik
Summary: In this population-based cohort study, thiopurine monotherapy was found to be an effective, safe, and durable treatment option for patients with inflammatory bowel disease (IBD), including both Crohn's disease (CD) and ulcerative colitis (UC), regardless of the era of initiation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Yang Zhang, Dandan Li, Heng Guo, Weina Wang, Xingang Li, Su Shen
Summary: This study indicated that the use of thiopurines in pregnant women with IBD does not increase the risk of congenital malformations, LBW, SGA, or spontaneous abortion, but it may be associated with an elevated risk of preterm birth when compared to IBD controls.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Medicine, General & Internal
D. A. Papachristos, M. Nikpour, C. Hair, W. M. Stevens
INTERNAL MEDICINE JOURNAL
(2015)
Article
Medicine, General & Internal
D. Q. Holt, J. F. McDonald, M. L. Murray, C. Hair, D. A. Devonshire, B. J. Strauss, G. T. Moore
INTERNAL MEDICINE JOURNAL
(2015)
Article
Gastroenterology & Hepatology
Olga Niewiadomski, Corrie Studd, Christopher Hair, Jarrad Wilson, John McNeill, Ross Knight, Emily Prewett, Paul Dabkowski, Damian Dowling, Sina Alexander, Benjamin Allen, Mark Tacey, William Connell, Paul Desmond, Sally Bell
JOURNAL OF CROHNS & COLITIS
(2015)
Article
Gastroenterology & Hepatology
Olga Niewiadomski, Corrie Studd, Chris Hair, Jarrad Wilson, Nik S. Ding, Neel Heerasing, Alvin Ting, John McNeill, Ross Knight, John Santamaria, Emily Prewett, Paul Dabkowski, Damian Dowling, Sina Alexander, Ben Allen, Benjamin Popp, William Connell, Paul Desmond, Sally Bell
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2015)
Article
Gastroenterology & Hepatology
Corrie Studd, Georgina Cameron, Lauren Beswick, Ross Knight, Christopher Hair, John McNeil, Paul Desmond, Jarrad Wilson, Wiliam Connell, Sally Bell
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2016)
Article
Medicine, General & Internal
O. Niewiadomski, C. Studd, J. Wilson, J. Williams, C. Hair, R. Knight, E. Prewett, P. Dabkowski, S. Alexander, B. Allen, D. Dowling, W. Connell, P. Desmond, S. Bell
INTERNAL MEDICINE JOURNAL
(2016)
Article
Gastroenterology & Hepatology
C. S. Hair, D. A. Devonshire
Editorial Material
Gastroenterology & Hepatology
N. S. Ding, A. Y. Ting, D. Loh, M. Leong, C. Hair
Article
Gastroenterology & Hepatology
Jarrad Wilson, Christopher Hair, Ross Knight, Anthony Catto-Smith, Sally Bell, Michael Kamm, Paul Desmond, John McNeil, William Connell
INFLAMMATORY BOWEL DISEASES
(2010)
Letter
Medicine, General & Internal
L. Beswick, A. Ting, F. Macrae, D. Dowling, C. Hair
INTERNAL MEDICINE JOURNAL
(2014)
Article
Medicine, General & Internal
J. P. Dwyer, A. Javed, C. S. Hair, G. T. Moore
INTERNAL MEDICINE JOURNAL
(2014)
Editorial Material
Gastroenterology & Hepatology
N. S. Ding, C. Hair, P. De Cruz, J. Watson
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2013)
Article
Oncology
Nik S. Ding, Sina Alexander, Michael P. Swan, Christopher Hair, Patrick Wilson, Emma Clarebrough, David Devonshire
JOURNAL OF ONCOLOGY
(2013)
Letter
Gastroenterology & Hepatology
Nikki Rae Adler, Marian Biddle, Lauren Beswick, Christopher Hair, Benjamin Allen, Stephen Graves, Aminul Islam, Jonathan P. Watson
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2013)
