Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury

Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss

(2018) Alina Wiesemann et al.   ANTIOXIDANTS & REDOX SIGNALING

The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment

(2018) Natasha C. Chang et al.   Cell Stem Cell

New mechanisms driving muscle stem cell regenerative decline with aging

(2018) Pedro Sousa-Victor et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: Correlation with blood monocyte counts.

(2018) David Linehan et al.   JOURNAL OF CLINICAL ONCOLOGY

The dual CCR2/CCR5 chemokine receptor antagonist Cenicriviroc reduces macrophage infiltration and disease severity in Duchenne muscular dystrophy (Dmdmdx-4Cv) mice

(2018) Feng Liang et al.   PLoS One

CCR2 deficiency does not provide sustained improvement of muscular dystrophy in mdx5cv mice

(2017) Wanming Zhao et al.   FASEB JOURNAL

CCR2− and CCR2+ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion

(2017) J Liu et al.   Mucosal Immunology

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Control of muscle formation by the fusogenic micropeptide myomixer

(2017) Pengpeng Bi et al.   SCIENCE

Ccl2/Ccr2 signalling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing

(2017) Mathieu Castela et al.   Nature Communications

Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development

(2017) Malgorzata E. Quinn et al.   Nature Communications

Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells

(2016) Hye Jin Jin et al.   ANTIOXIDANTS & REDOX SIGNALING

p38δ MAPKHighlights

(2016) Kristiina Rajamäki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration

(2016) David W. Melton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling

(2016) Michael J. Moravan et al.   Journal of Neuroinflammation

Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability

(2016) Erik J. Groessl et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

Regenerative decline of stem cells in sarcopenia

(2016) Pedro Sousa-Victor et al.   MOLECULAR ASPECTS OF MEDICINE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

(2015) Dario R Lemos et al.   NATURE MEDICINE

The central role of muscle stem cells in regenerative failure with aging

(2015) Helen M Blau et al.   NATURE MEDICINE

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial

(2015) Dick de Zeeuw et al.   Lancet Diabetes & Endocrinology

Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state

(2014) J. V. Chakkalakal et al.   DEVELOPMENT

Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2

(2014) K. Mojumdar et al.   EMBO Molecular Medicine

CCR2 Deficiency Impairs Macrophage Infiltration and Improves Cognitive Function after Traumatic Brain Injury

(2014) Christine L. Hsieh et al.   JOURNAL OF NEUROTRAUMA

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

(2014) Benjamin D Cosgrove et al.   NATURE MEDICINE

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis

(2013) D. E. Sanford et al.   CLINICAL CANCER RESEARCH

Cellular dynamics in the muscle satellite cell niche

(2013) C Florian Bentzinger et al.   EMBO REPORTS

Myomaker is a membrane activator of myoblast fusion and muscle formation

(2013) Douglas P. Millay et al.   NATURE

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

(2012) Monika Julia Wolf et al.   CANCER CELL

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

The aged niche disrupts muscle stem cell quiescence

(2012) Joe V. Chakkalakal et al.   NATURE

Effect of CC Chemokine Receptor 2 CCR2 Blockade on Serum C-Reactive Protein in Individuals at Atherosclerotic Risk and With a Single Nucleotide Polymorphism of the Monocyte Chemoattractant Protein-1 Promoter Region

(2011) Jim Gilbert et al.   AMERICAN JOURNAL OF CARDIOLOGY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment

(2010) Carlo O. Martinez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

FGF2 Induces ERK Phosphorylation Through Grb2 and PKC during Quiescent Myogenic Cell Activation

(2010) Yosuke Nagata et al.   CELL STRUCTURE AND FUNCTION

Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury

(2010) Haiyan Lu et al.   FASEB JOURNAL

Chemokines and chemokine receptors: new insights into cancer-related inflammation

(2010) Gwendal Lazennec et al.   TRENDS IN MOLECULAR MEDICINE

p38-γ–dependent gene silencing restricts entry into the myogenic differentiation program

(2009) Mark A. Gillespie et al.   JOURNAL OF CELL BIOLOGY

CC family chemokines directly regulate myoblast responses to skeletal muscle injury

(2008) Linda Yahiaoui et al.   JOURNAL OF PHYSIOLOGY-LONDON