Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer

MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism

(2020) Appolinaire A. Olou et al.   ONCOGENE

Anlotinib inhibits synovial sarcoma by targeting GINS1: a novel downstream target oncogene in progression of synovial sarcoma

(2019) L. Tang et al.   Clinical & Translational Oncology

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

China National Medical Products Administration approval summary: anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy

(2019) Ming Zhou et al.   Cancer Communications

Validated Nomogram Predicting 6-Month Survival in Pancreatic Cancer Patients Receiving First-Line 5-Fluorouracil, Oxaliplatin, and Irinotecan

(2019) Lorenzo Fornaro et al.   Clinical Colorectal Cancer

Variants in oxidative stress-related genes affect the chemosensitivity through Nrf2-mediated signaling pathway in biliary tract cancer

(2019) Ming Zhan et al.   EBioMedicine

Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer

(2019) Yong-Jiang Li et al.   Acta Biomaterialia

Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species

(2018) Chen-chun Zhong et al.   ACTA PHARMACOLOGICA SINICA

Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer

(2018) Xi Cheng et al.   CANCER LETTERS

Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor

(2018) Chengying Xie et al.   CANCER SCIENCE

Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients With Refractory Metastatic Soft Tissue Sarcoma

(2018) Yihebali Chi et al.   CLINICAL CANCER RESEARCH

Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells

(2018) Yu-Huei Liu et al.   PHYTOMEDICINE

Anlotinib induces hepatocellular carcinoma apoptosis and inhibits proliferation via Erk and Akt pathway

(2018) Chao He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Antitumor effects of anlotinib in thyroid cancer

(2018) Xianhui Ruan et al.   ENDOCRINE-RELATED CANCER

Combined inhibition of autophagy and Nrf2 signaling augments bortezomib-induced apoptosis by increasing ROS production and ER stress in pancreatic cancer cells

(2018) Xu Li et al.   International Journal of Biological Sciences

Results from a Monocentric Long‐Term Analysis of 23 Patients with Ovarian Sertoli‐Leydig Cell Tumors

(2018) Sebastien Gouy et al.   ONCOLOGIST

Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

(2018) Jen-Yang Tang et al.   SEMINARS IN CANCER BIOLOGY

Anlotinib for Refractory Advanced Non–Small Cell Lung Cancer in China

(2018) Xin-Zu Chen   JAMA Oncology

FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib

(2017) Lixia Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy

(2017) Iris C. Salaroglio et al.   Molecular Cancer

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

Polypeptide from Chlamys farreri suppresses ultraviolet-B irradiation-induced apoptosis through restoring ER redox homeostasis, scavenging ROS generation, and suppressing the PERK-eIF2a-CHOP pathway in HaCaT cells

(2015) Feng Zhong et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Addressing the challenges of pancreatic cancer: Future directions for improving outcomes

(2015) Manuel Hidalgo et al.   PANCREATOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells

(2012) Xiaohan Zhai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE