Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

(2019) Ying Jiang et al.   NATURE

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

(2019) Luca Cassetta et al.   CANCER CELL

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

(2019) Mark A. Eckert et al.   NATURE

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

(2019) Antonio Sica et al.   Cell Metabolism

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury

(2019) Tomoyuki Miyauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

The metabolic regulator Lamtor5 suppresses inflammatory signaling via regulating mTOR-mediated TLR4 degradation

(2019) Wei Zhang et al.   Cellular & Molecular Immunology

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

(2019) Liangliang Ji et al.   IMMUNITY

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Aerobic glycolysis is a metabolic requirement to maintain the M2-like polarization of tumor-associated macrophages

(2019) Natália M. de-Brito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

(2018) Wei Li et al.   Cell Metabolism

TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy

(2018) Lan Huang et al.   Cellular & Molecular Immunology

Metabolic Modulation in Macrophage Effector Function

(2018) Ciana Diskin et al.   Frontiers in Immunology

Four Key Steps Control Glycolytic Flux in Mammalian Cells

(2018) Lukas Bahati Tanner et al.   Cell Systems

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

(2018) Feilong Wang et al.   Cell Metabolism

FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma

(2018) Sangwoon Chung et al.   ALLERGY

Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

(2018) Jan Van den Bossche et al.   Cell Metabolism

Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1

(2018) Hui Yan et al.   DIABETES

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

FoxO1 is a regulator of MHC-II expression and anti-tumor effect of tumor-associated macrophages

(2017) Jing-Bo Yang et al.   ONCOGENE

Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1

(2017) Federica Raggi et al.   Frontiers in Immunology

Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

(2016) G. Jiang et al.   Cancer Prevention Research

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Forkhead Box O1 Regulates Macrophage Polarization Following Staphylococcus aureus Infection: Experimental Murine Data and Review of the Literature

(2016) Yu-Chen Wang et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer

(2016) Joanna M. Poczobutt et al.   JOURNAL OF IMMUNOLOGY

CAFs and TAMs: maestros of the tumour microenvironment

(2016) Yoshihiro Komohara et al.   JOURNAL OF PATHOLOGY

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

High-Content Screening for Quantitative Cell Biology

(2016) Mojca Mattiazzi Usaj et al.   TRENDS IN CELL BIOLOGY

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Inhibition of Cyclin-Dependent Kinase Phosphorylation of FOXO1 and Prostate Cancer Cell Growth by a Peptide Derived from FOXO1

(2015) Huarui Lu et al.   NEOPLASIA

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: implication in hyperglycemia

(2014) Sangwoon Chung et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Inhibition of FoxO1 nuclear exclusion prevents metastasis of Glioblastoma

(2014) Jin Chen et al.   TUMOR BIOLOGY

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

(2013) F. O. Martinez et al.   BLOOD

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Homozygosity for an Allele Encoding Deacetylated FoxO1 Protects Macrophages From Cholesterol-Induced Inflammation Without Increasing Apoptosis

(2011) Kyoichiro Tsuchiya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

(2011) Utpal B Pajvani et al.   NATURE MEDICINE

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

(2010) WuQiang Fan et al.   EMBO JOURNAL

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The variation in cytoplasmic distribution of mouse peritoneal macrophage during phagocytosis modulated by mangiferin, an immunomodulator

(2008) Atasi De et al.   IMMUNOBIOLOGY

Quality control by the ribosome following peptide bond formation

(2008) Hani S. Zaher et al.   NATURE

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY