Article
Plant Sciences
Qiumei Fan, Xiaowei Liang, Zhipeng Xu, Siyuan Li, Shan Han, Yuntian Xiao, Qiongming Xu, Renyikun Yuan, Shilin Yang, Hongwei Gao
Summary: In this study, it was found that Pedunculoside (PE), a triterpene saponin extracted from Ilex rotunda Thunb., can reverse NSCLC metastasis and improve Gefitinib resistance through the MAPK and Nrf(2) pathways, subsequently suppressing lung metastasis in B16-F10 lung metastatic mice model. These findings suggest that PE has potential use in inhibiting NSCLC metastasis and improving Gefitinib resistance.
Article
Chemistry, Multidisciplinary
Xing-mei Liang, Qiong Qin, Bo-ning Liu, Xiao-qing Li, Li-li Zeng, Jing Wang, Ling-ping Kong, Dian-sheng Zhong, Lin-lin Sun
Summary: The study reveals that DNA damage repair capacity is compromised in osimertinib-resistant cells, and inhibiting DNA-PK can increase sensitivity to osimertinib. Combination of osimertinib with DNA-PK inhibitors synergistically suppresses proliferation of resistant cells.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Hui Guo, Yan Qin Tan, Xiaoming Huang, Shuwei Zhang, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie
Summary: This study investigated the efficacy of a small molecule inhibitor of TFF3 (AMPC) in enhancing sensitivity and mitigating acquired resistance to tamoxifen in ER+ mammary carcinoma cells. AMPC restored the sensitivity to tamoxifen and enhanced the efficacy of Taxanes in tamoxifen-resistant ER+MC. Pharmacological inhibition of TFF3 may serve as an effective combinatorial therapeutic strategy for the treatment of tamoxifen-resistant ER+MC.
Article
Pharmacology & Pharmacy
Xueting Cai, Jing Miao, Rongwei Sun, Sainan Wang, Miguel Angel Molina-Vila, Imane Chaib, Rafael Rosell, Peng Cao
Summary: Osimertinib-resistant EGFR-mutant NSCLC cell lines showed increased heme levels, while plasma heme levels were also elevated in patients treated with osimertinib. The antimalarial drug DHA was found to reverse osimertinib resistance by enhancing ROS levels and impairing heme metabolism. Combination treatment of osimertinib and DHA inhibited tumor growth and downregulated RTKs in a xenograft mouse model.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biology
Xiaolong Tang, Lizhi Cheng, Guo Li, Yong-Ming Yan, Fengting Su, Dan-Ling Huang, Shuping Zhang, Zuojun Liu, Minxian Qian, Ji Li, Yong-Xian Cheng, Baohua Liu
Summary: The small molecule compound D6 demonstrates promising efficacy in treating EGFR-TKI resistant NSCLC by targeting the protein-protein interaction between HSP90 and T790M-EGFR, offering a potential alternative strategy to overcome drug resistance.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tae Woo Kim, Hee Gu Lee
Summary: In women, ovarian cancer ranks fifth in terms of mortality worldwide. Cancer therapies like surgery, radiotherapy, and chemotherapy have various issues, including resistance, toxicity, and side effects. Natural herbal medicine could be a potential option for cancer therapy due to its low toxicity, minimal side effects, and high success rates. This study investigates the anti-cancer effects of 6-shogaol in ovarian cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Miso Kim, Soyeon Kim, Jeemin Yim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Dae Seog Heo
Summary: This study demonstrated that high expression of CD73 adversely affects the survival of patients with EGFR-mutant NSCLC. Inhibiting CD73 in EGFR-TKI-resistant cell lines resulted in increased apoptosis and cell cycle arrest, overcoming the acquired resistance to first-generation EGFR-TKIs. Further research is needed to determine whether blocking CD73 plays a therapeutic role in EGFR-TKI-resistant patients with EGFR-mutant NSCLC.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Pharmacology & Pharmacy
Jinling Cui, Shuang Zhao, Hui Chen, Yuhan Fu, Kai Han, Shutao Yin, Chong Zhao, Lihong Fan, Hongbo Hu
Summary: Acquired resistance to EGFR TKI therapy compromises its efficacy in NSCLC. MET activation is a key strategy for cancer cells to acquire a refractory phenotype. The dysregulated amino acid metabolisms, including elevated expression of ASCT2, SLC7A11, and ASNS, contribute to the survival advantage of gefitinib-resistant cells. MSeA effectively suppresses tumor growth and inactivates the MET-TOPK signaling axis in gefitinib-resistant NSCLC.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Chenchen Guo, Ruijie Wan, Yayi He, Shu-Hai Lin, Jiayu Cao, Ying Qiu, Tengfei Zhang, Qiqi Zhao, Yujia Niu, Yujuan Jin, Hsin-Yi Huang, Xue Wang, Li Tan, Roman K. Thomas, Hua Zhang, Luonan Chen, Kwok-Kin Wong, Liang Hu, Hongbin Ji
Summary: The study demonstrates that the metabolic reprogramming in SCLC leads to chemotherapy resistance, and highlights the mevalonate pathway as a target for overcoming chemoresistance using statins.
Article
Biochemistry & Molecular Biology
Wenli Hu, Yurong Ma, Chong Zhao, Shutao Yin, Hongbo Hu
Summary: This study demonstrated that MSeA can effectively attenuate cisplatin-induced PD-L1 expression, enhance its cytotoxicity, and improve tumor sensitivity to chemotherapy drugs. Additionally, MSeA also inhibits IFN-gamma-induced tumor PD-L1 expression, enhances T-cell immunity, and improves the efficacy of chemotherapy drugs.
MOLECULAR CARCINOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Koujun Zhu, Jun Zhu, Jichun Geng, Yongjian Zhang, Yan Qin, Fudong Wang, Yuan Weng
Summary: This study investigated the role of circSNX6 in drug resistance of NSCLC exposed to cisplatin, revealing its influence on cell viability, proliferation, and apoptosis by regulating miR-137 and CXCL12. These findings provide solid groundings for further understanding of NSCLC pathogenesis and therapeutic development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Jicheng Han, Cheng Cheng, Jinxin Zhang, Jinbo Fang, Wei Yao, Yilong Zhu, Zhiru Xiu, Ningyi Jin, Huijun Lu, Xiao Li, Yiquan Li
Summary: In this study, it was found that myricetin inhibits the activation of pyroptosis in lung cancer cells by cleaving GSDME. It was also found that myricetin induces endoplasmic reticulum stress and increases reactive oxygen species levels, leading to the inhibition of pyroptosis. In vivo experiments showed that myricetin reduces tumor volume and increases pyroptosis-related protein levels in tumor tissues.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Luwei Han, Xiaomeng Zhang, Zhiqiang Wang, Xian Zhang, Liwen Zhao, Wei Fu, Xiaobo Liang, Zhibo Zhang, Yong Wang
Summary: SH-1028 is a new third-generation EGFR inhibitor that shows potent activity against EGFR sensitive and resistant (T790M) mutations. In mouse xenograft models, oral administration of SH-1028 at a daily dose of 5 mg/kg significantly inhibited proliferation of tumor cells with EGFR sensitive and resistant mutation for consecutive 14 days, with no TKI-induced weight loss. The main metabolite of SH-1028, Imp3, showed no wild-type EGFR inhibition or off-target effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xi Chen, Hangshuo Zhang, Yuzhu Pan, Ning Zhu, Lisha Zhou, Guang Chen, Jiabing Wang
Summary: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of all cases. Nimbolide (NB), a compound derived from the neem tree, has been shown to exhibit anti-cancer properties in various types of cancer cells. In this study, the researchers investigated the effect of NB on A549 human NSCLC cells and found that NB treatment inhibited the colony formation of these cells in a dose-dependent manner. The mechanism behind this anti-cancer effect was found to involve the induction of cellular reactive oxygen species (ROS), resulting in endoplasmic reticulum (ER) stress, DNA damage, and ultimately apoptosis in the NSCLC cells.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Ping Cui, Fanfan Chen, Guoxu Ma, Wenlan Liu, Lei Chen, Sicen Wang, Weiping Li, Zongyang Li, Guodong Huang
Summary: This study identified a compound called OLB as having potent antiglioma activity against TMZ-resistant GBM cells and GBM organoid models, unveiling its apoptosis-inducing mechanism and action.
Article
Cell Biology
Tae Woo Kim, Seon Young Lee, Mia Kim, Chunhoo Cheon, Bo-Hyoung Jang, Yong Cheol Shin, Seong-Gyu Ko
CELL DEATH & DISEASE
(2018)
Article
Oncology
Tae Woo Kim, Seung Ro Han, Jong-Tae Kim, Seung-Min Yoo, Myung-Shin Lee, Seung-Hoon Lee, Yun Hee Kang, Hee Gu Lee
Article
Oncology
Tae Woo Kim, Da-Won Hong, Joung Whan Park, Sung Hee Hong
BRITISH JOURNAL OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Tae Woo Kim, Da-Won Hong, Chang-Mo Kang, Sung Hee Hong
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Article
Cell Biology
Tae Woo Kim, Chunhoo Cheon, Seong-Gyu Ko
CELL DEATH & DISEASE
(2020)
Article
Chemistry, Multidisciplinary
Tae Woo Kim
Summary: CA induces cell death in gastric cancer cells through ER stress and Ca2+ release, and inhibiting ER stress can mitigate the cytotoxicity of CA. CA also triggers autophagic cell death by inhibiting G9a and activating LC3B.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Multidisciplinary Sciences
Tae Woo Kim, Da-Won Hong, Sung Hee Hong
Summary: In this study, a novel benzothiazole derivative PB01 was shown to have antitumor effects in radiation-resistant human NSCLC cells by inducing cell death and inhibiting epithelial-to-mesenchymal transition. The mechanism involved induction of reactive oxygen species, ER stress, and activation of the ATR axis, suggesting that PB01 treatment could overcome radio-resistance during NSCLC radiotherapy.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Tae Woo Kim, Hee Gu Lee
Summary: The study found that APG can treat gastric cancer by promoting autophagic cell death, increasing levels of ATG5, LC3-II, and phosphorylation of AMPK and ULK1, while down-regulating p-mTOR and p62. Additionally, APG induces autophagic cell death through the activation of the PERK signaling, indicating an endoplasmic reticulum stress response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Taewoo Kim, Seong-Gyu Ko
Summary: JI017 is a potent anti-cancer drug for ovarian cancer treatment, mediating endoplasmic reticulum stress and apoptosis through the Nox4-PERK-CHOP signaling pathway. Combination treatment with radiation can overcome radioresistance in ovarian cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tae Woo Kim, Seong-Gyu Ko
Summary: The study presents a novel herbal extract, JI017, that induces cell death and ER stress in breast cancer cells, and overcomes paclitaxel resistance by blocking EMT processes. These findings suggest that JI017 may serve as a powerful anti-cancer agent in breast cancer and a potential therapy for paclitaxel-resistant breast cancer.
Article
Biochemistry & Molecular Biology
Tae Woo Kim, Hee Gu Lee
Summary: In women, ovarian cancer ranks fifth in terms of mortality worldwide. Cancer therapies like surgery, radiotherapy, and chemotherapy have various issues, including resistance, toxicity, and side effects. Natural herbal medicine could be a potential option for cancer therapy due to its low toxicity, minimal side effects, and high success rates. This study investigates the anti-cancer effects of 6-shogaol in ovarian cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tae Woo Kim
Summary: This study examines the anti-inflammatory and anti-cancer effects of fisetin, a natural flavonoid. The results show that fisetin can reduce inflammation and induce cancer cell death through ER stress. It also overcomes radiation resistance and induces cell death in liver cancer cells. Therefore, fisetin combined with radiation may be a powerful immunotherapy strategy to overcome resistance in an inflammatory tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tae Woo Kim
Summary: Angelica gigas has a potent anti-tumor and anti-cancer effect. This study focused on the bioactive compound nodakenin and its effects on breast cancer. Nodakenin was found to inhibit breast cancer cell viability, decrease tumor volume in mice, and induce apoptosis. It also affected signaling pathways and calcium release. Additionally, nodakenin combined with radiation overcame radioresistance in breast cancer cells. These findings suggest nodakenin as a potential therapeutic strategy for breast cancer.
Article
Biochemistry & Molecular Biology
Seon-Jin Lee, Tae Woo Kim, Gyeong Lim Park, Yo Sep Hwang, Hee Jun Cho, Jong-Tae Kim, Hee Gu Lee