Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

Receptor-mediated cell entry of paramyxoviruses: Mechanisms, and consequences for tropism and pathogenesis

(2020) Chanakha K. Navaratnarajah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

An Infectious cDNA Clone of SARS-CoV-2

(2020) Xuping Xie et al.   Cell Host & Microbe

Could the D614 G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?

(2020) Muthukrishnan Eaaswarkhanth et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity

(2020) Yuanmei Zhu et al.   JOURNAL OF VIROLOGY

Therapeutic efficacy and resistance selection of a lipopeptide fusion inhibitor in simian immunodeficiency virus (SIV)-infected rhesus macaques

(2020) Danwei Yu et al.   JOURNAL OF VIROLOGY

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

(2020) Timothy P. Sheahan et al.   Science Translational Medicine

A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?

(2020) Sung-Jae Kim et al.   Vaccines

Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment

(2020) Takahiko Koyama et al.   Pathogens

Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility

(2020) Arindam Maitra et al.   JOURNAL OF BIOSCIENCES

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

(2020) Na Zhu et al.   Nature Communications

Monotherapy with a low-dose lipopeptide HIV fusion inhibitor maintains long-term viral suppression in rhesus macaques

(2019) Huihui Chong et al.   PLoS Pathogens

Inhibiting Human Parainfluenza Virus Infection by Preactivating the Cell Entry Mechanism

(2019) S. F. Bottom-Tanzer et al.   mBio

A Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life

(2019) Shan Su et al.   MOLECULES

Design and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity

(2019) Yuanmei Zhu et al.   JOURNAL OF VIROLOGY

Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route

(2019) Cyrille Mathieu et al.   JOURNAL OF VIROLOGY

Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids

(2019) M. Porotto et al.   mBio

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

(2019) Shuai Xia et al.   Science Advances

Dual Inhibition of Human Parainfluenza Type 3 and Respiratory Syncytial Virus Infectivity with a Single Agent

(2019) Victor K. Outlaw et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma

(2018) K. Looi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Design of Novel HIV-1/2 Fusion Inhibitors with Efficient Therapeutic Efficacy in Rhesus Monkey Models

(2018) Huihui Chong et al.   JOURNAL OF VIROLOGY

Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation

(2018) Sho Iketani et al.   mBio

Structure–Stability–Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles

(2018) Tiago N. Figueira et al.   ACS Nano

Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane

(2018) T. N. Figueira et al.   BIOCONJUGATE CHEMISTRY

Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition

(2017) Xiaohui Ding et al.   JOURNAL OF VIROLOGY

A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly Potent In Vitro , Ex Vivo , and In Vivo Antiviral Activity

(2017) Huihui Chong et al.   JOURNAL OF VIROLOGY

cAMP-dependent activation of protein kinase A attenuates respiratory syncytial virus-induced human airway epithelial barrier disruption

(2017) Fariba Rezaee et al.   PLoS One

Lipidation increases antiviral activities of coronavirus fusion-inhibiting peptides

(2017) Jung-Eun Park et al.   VIROLOGY

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides

(2017) Cyrille Mathieu et al.   Scientific Reports

Rapid Metagenomic Next-Generation Sequencing during an Investigation of Hospital-Acquired Human Parainfluenza Virus 3 Infections

(2016) Alexander L. Greninger et al.   JOURNAL OF CLINICAL MICROBIOLOGY

In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence

(2016) T. N. Figueira et al.   JOURNAL OF VIROLOGY

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

(2015) Rudragouda Channappanavar et al.   JOURNAL OF INFECTIOUS DISEASES

Cigarette Smoke–Induced Disruption of Bronchial Epithelial Tight Junctions Is Prevented by Transforming Growth Factor-β

(2014) Andrea C. Schamberger et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Circulating Clinical Strains of Human Parainfluenza Virus Reveal Viral Entry Requirements for In Vivo Infection

(2014) S. G. Palmer et al.   JOURNAL OF VIROLOGY

Prevention of Measles Virus Infection by Intranasal Delivery of Fusion Inhibitor Peptides

(2014) C. Mathieu et al.   JOURNAL OF VIROLOGY

Human bocavirus 1 infects commercially available primary human airway epithelium cultures productively

(2013) Xuefeng Deng et al.   JOURNAL OF VIROLOGICAL METHODS

Fatal Measles Virus Infection Prevented by Brain-Penetrant Fusion Inhibitors

(2013) J. C. Welsch et al.   JOURNAL OF VIROLOGY

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

A General Strategy to Endow Natural Fusion-protein-Derived Peptides with Potent Antiviral Activity

(2012) Antonello Pessi et al.   PLoS One

Capturing a Fusion Intermediate of Influenza Hemagglutinin with a Cholesterol-conjugated Peptide, a New Antiviral Strategy for Influenza Virus

(2011) Kelly K. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Recombinant Sialidase Fusion Protein Effectively Inhibits Human Parainfluenza Viral Infection In Vitro and In Vivo

(2010) Anne Moscona et al.   JOURNAL OF INFECTIOUS DISEASES

Viral Entry Inhibitors Targeted to the Membrane Site of Action

(2010) M. Porotto et al.   JOURNAL OF VIROLOGY

Inhibition of Nipah Virus Infection In Vivo: Targeting an Early Stage of Paramyxovirus Fusion Activation during Viral Entry

(2010) Matteo Porotto et al.   PLoS Pathogens

Human Parainfluenza Virus Infection of the Airway Epithelium: Viral Hemagglutinin-Neuraminidase Regulates Fusion Protein Activation and Modulates Infectivity

(2009) L. M. Palermo et al.   JOURNAL OF VIROLOGY

Global Transmission of Oseltamivir-Resistant Influenza

(2009) Anne Moscona   NEW ENGLAND JOURNAL OF MEDICINE

Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

(2008) Judith M. White et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Viral membrane fusion

(2008) Stephen C Harrison   NATURE STRUCTURAL & MOLECULAR BIOLOGY