Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema

Pro-permeability Factors in Diabetic Macular Edema; the Diabetic Macular Edema Treated With Ozurdex Trial

(2016) Peter A. Campochiaro et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Anti–Vascular Endothelial Growth Factor Agents in the Treatment of Retinal Disease

(2016) Peter A. Campochiaro et al.   OPHTHALMOLOGY

Enhanced Benefit in Diabetic Macular Edema from AKB-9778 Tie2 Activation Combined with Vascular Endothelial Growth Factor Suppression

(2016) Peter A. Campochiaro et al.   OPHTHALMOLOGY

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

(2015) Maike Frye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment of Diabetic Macular Edema with an Inhibitor of Vascular Endothelial-Protein Tyrosine Phosphatase That Activates Tie2

(2015) Peter A. Campochiaro et al.   OPHTHALMOLOGY

Molecular pathogenesis of retinal and choroidal vascular diseases

(2015) Peter A. Campochiaro   PROGRESS IN RETINAL AND EYE RESEARCH

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

(2014) Jikui Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy

(2012) Sirpa Loukovaara et al.   ACTA OPHTHALMOLOGICA

Long-term Effects of Ranibizumab on Diabetic Retinopathy Severity and Progression

(2012) Michael S. Ip   ARCHIVES OF OPHTHALMOLOGY

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

(2012) J. W. Y. Yau et al.   DIABETES CARE

COMP-Angiopoietin-1 Recovers Molecular Biomarkers of Neuropathy and Improves Vascularisation in Sciatic Nerve of ob/ob Mice

(2012) Joanna Kosacka et al.   PLoS One

Angiopoietin-1 Requires IQ Domain GTPase-Activating Protein 1 to Activate Rac1 and Promote Endothelial Barrier Defense

(2011) Sascha David et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study

(2011) Sazan Rasul et al.   Cardiovascular Diabetology

Intracavernous Delivery of a Designed Angiopoietin-1 Variant Rescues Erectile Function by Enhancing Endothelial Regeneration in the Streptozotocin-Induced Diabetic Mouse

(2011) Hai-Rong Jin et al.   DIABETES

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

(2011) Marie Jeansson et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical and Genetic Correlates of Circulating Angiopoietin-2 and Soluble Tie-2 in the Community

(2010) Wolfgang Lieb et al.   Circulation-Cardiovascular Genetics

Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells

(2009) Orisha K. Yacyshyn et al.   ANGIOGENESIS

Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes

(2009) K Kinnunen et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study–74)

(2009) Sathish Anuradha et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases

(2009) Takeru Yoshimura et al.   PLoS One

Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis

(2008) Qin-hui Tuo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Disruption of Ang-1/Tie-2 Signaling Contributes to the Impaired Myocardial Vascular Maturation and Angiogenesis in Type II Diabetic Mice

(2008) Jian-Xiong Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor

(2008) Jung-Sun Lee et al.   CARDIOVASCULAR RESEARCH

Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression

(2008) Alessandra Bitto et al.   CLINICAL SCIENCE

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1  (HIF-1 )-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1  Expression, and Normalizes Immature Vasculature in db/db Mice

(2008) J.-X. Chen et al.   DIABETES

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY