Article
Medicine, General & Internal
Ning-Yi Hsia, Chun-Ju Lin, Huan-Sheng Chen, Cheng-Hsien Chang, Henry Bair, Chun-Ting Lai, Jane-Ming Lin, Wen-Lu Chen, Peng-Tai Tien, Wen-Chuan Wu, Yi-Yu Tsai
Summary: Switching to DEX implants for refractory DME patients after ranibizumab treatment showed improvements in BCVA and CRT, with good tolerability. Patients with higher baseline CRT and worse BCVA had better therapeutic responses.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mauricio Pinto, Thibaud Mathis, Pascale Massin, Jad Akesbi, Theo Lereuil, Nicolas Voirin, Frederic Matonti, Franck Fajnkuchen, John Conrath, Solange Milazzo, Jean-Francois Korobelnik, Stephanie Baillif, Philippe Denis, Catherine Creuzot-Garcher, Mayer Srour, Benedicte Dupas, Aditya Sudhalkar, Alper Bilgic, Ramin Tadayoni, Eric H. Souied, Corinne Dot, Laurent Kodjikian
Summary: Based on the NAVDEX study, patients with drug-naive diabetic macular edema can be divided into two groups based on baseline visual acuity, and ellipsoid zone alterations or disorganization of retinal inner layers negatively impact final vision. The study shows that despite a low baseline visual acuity, treatment with dexamethasone implant can lead to significant visual gains.
Article
Ophthalmology
Thibaud Mathis, Alessio Cerquaglia, Michel Weber, Rebecca Guillarme-Sallit, Ariane Malcles, Nicolas Voirin, Marion Servant, Aditya Sudhalkar, Alper Bilgic, Philippe Denis, Pascal Seve, Bahram Bodaghi, Laurent Kodjikian
Summary: The study confirms the efficacy and safety of the dexamethasone implant in noninfectious uveitis, showing improvements in visual acuity and reduction in symptoms like edema and vitreous haze. However, ocular hypertension and cataract occurred in a significant percentage of patients, which requires timely management and intervention.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Silvia N. W. Hertzberg, Morten Carstens Moe, Oystein Kalsnes Jorstad, Beata Eva Petrovski, Emily Burger, Goran Petrovski
Summary: This study aimed to estimate the 1-year costs of treating diabetic macular oedema (DME) patients using anti-vascular endothelial growth factor (anti-VEGF) biologics and the dexamethasone implant. The study found that using dexamethasone as a first-line treatment may increase economic costs, while treating resistant DME with dexamethasone may reduce costs and treatment burden.
ACTA OPHTHALMOLOGICA
(2022)
Article
Multidisciplinary Sciences
Huiling Tan, Xin Wang, Kaiyou Ye, Jianmin Lin, E. Song, Lihua Gong
Summary: This study investigated the prevalence and risk factors of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes mellitus (T2DM) in Qingpu, Shanghai. The prevalence of DR was 10.1%, with non-proliferative DR being more common. Higher fasting plasma glucose and glycated hemoglobinA1c were identified as known risk factors for DR, while no association was found between lipid indicators and DR. Additionally, higher levels of urea nitrogen and urinary albumin were associated with an increased risk of DR.
Article
Multidisciplinary Sciences
Svenja Deuchler, Ralf Schubert, Pankaj Singh, Adonis Chedid, Natallia Brui, Ninel Kenikstul, Thomas Kohnen, Hanns Ackermann, Frank Koch
Summary: This study aimed to sample vitreous fluid from patients with diabetic retinopathy (DR) to assess the expression of growth and inflammatory factors (GIF). The results showed that the expression of CD54, IL-8, and PIGF was significantly higher in patients with proliferative DR compared to those with non-proliferative DR, suggesting their potential importance in defining and monitoring the effectiveness of patient therapy.
Article
Ophthalmology
John R. O'Fee, Joseph Juliano, Andrew A. Moshfeghi
Summary: This study identified factors associated with diabetic macular edema (DME) and characterized the types of DME in eyes with proliferative diabetic retinopathy (PDR). The presence of younger age and epiretinal membrane (ERM) were found to be significantly associated with center-involving DME (CI-DME).
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Pichai Jirarattanasopa, Sakunjanut Jiranoppasakdawong, Mansing Ratanasukon, Patama Bhurayanontachai, Wantanee Dangboon
Summary: This retrospective study evaluated the efficacy of intravitreal dexamethasone implants for treating macular edema associated with retinal vascular diseases. The results showed improvements in visual acuity and central retinal thickness over a 6-month period. Reinjection may be associated with a higher baseline retinal thickness.
Article
Endocrinology & Metabolism
Dariusz Tarasewicz, Carol Conell, Lisa K. Gilliam, Ronald B. Melles
Summary: The study aimed to determine the importance of blood sugar control, blood pressure, and other systemic factors on the risk of diabetic retinopathy progression. The findings confirmed that glucose control, as measured by HbA1c, was the most important modifiable risk factor, followed by blood pressure control and total cholesterol. Non-white patients generally had a higher risk of progression to diabetic retinopathy, while Asian patients were less likely to develop diabetic macular edema.
ACTA DIABETOLOGICA
(2023)
Article
Ophthalmology
Dilsher S. Dhoot, Hadi Moini, Kimberly Reed, Weiming Du, Robert Vitti, Alyson J. Berliner, Rishi P. Singh
Summary: This study aimed to assess the time to, cumulative incidence of, and functional benefit of achieving sustained improvement in diabetic macular oedema (DMO) in terms of the Diabetic Retinopathy Severity Scale (DRSS). The results showed that patients treated with intravitreal aflibercept injections achieved sustained improvement in DRSS earlier and more frequently compared to laser treatment, and this improvement was associated with greater improvement in visual acuity, independent of central subfield thickness reduction.
Article
Biology
Daniel Duck-Jin Hwang
Summary: This study explored the use of spectral-domain optical coherence tomography (OCT) biomarkers to predict short-term anatomical improvement in diabetic macular edema (DME) patients who did not respond to anti-vascular endothelial growth factor (anti-VEGF) treatment and received dexamethasone (DEX) injections. The results showed that OCT parameters such as optical density (ODN) and optical density ratio (ODR) of the outer nuclear layer (ONL) cysts were correlated with changes in central macular thickness (CMT) after DEX injection, suggesting that these biomarkers could be useful in predicting short-term CMT responses after DEX injection in anti-VEGF non-responders.
Article
Multidisciplinary Sciences
Xi Yao, Xiaoting Pei, Yingrui Yang, Hongmei Zhang, Mengting Xia, Ranran Huang, Yuming Wang, Zhijie Li
Summary: The study found that different age, region, disease duration, and DR severity could affect the prevalence and association rules of eye diseases in diabetic patients. Patients in rural areas and older age groups are more likely to develop eye diseases, and those with multiple eye diseases concurrently have a higher risk.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Takuya Utsumi, Hidetaka Noma, Kanako Yasuda, Hiroshi Goto, Masahiko Shimura
Summary: The study aimed to investigate changes in the aqueous humor levels of growth factors and inflammatory mediators in patients with diabetic macular edema after intravitreal ranibizumab injection. The findings suggest that these changes may not only be anatomical responses but also potential therapeutic targets for DME treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: This study examined the relationship between diabetic retinopathy (DR) and systemic factors in 261 patients with type 2 diabetes. Logistic regression analyses revealed that the duration of diabetes, average and highest HbA1c levels, and grade of diabetic nephropathy (DN) significantly correlated with the development of DR. Additionally, the severity of DR was significantly correlated with the duration of diabetes, average HbA1c level, and severity of DN. Logistic regression analyses also showed a significant correlation between the development of diabetic macular edema (DME) and the grade of DN. DN grade is associated with the development of DR and DME, and decreased renal function predicts the onset of DR.
Article
Ophthalmology
Noemi Lois, Christina Campbell, Norman Waugh, Augusto Azuara-Blanco, Mandy Maredza, Hema Mistry, Danny McAuley, Nachiketa Acharya, Tariq M. Aslam, Clare Bailey, Victor Chong, Louise Downey, Haralabos Eleftheriadis, Samia Fatum, Sheena George, Faruque Ghanchi, Markus Groppe, Robin Hamilton, Geeta Menon, Ahmed Saad, Sobha Sivaprasad, Marianne Shiew, David H. Steel, James Stephen Talks, Paul Doherty, Cliona McDowell, Mike Clarke
Summary: The purpose of this study was to compare the clinical effectiveness, safety, and cost-effectiveness of subthreshold micropulse laser (SML) and standard laser (SL) for diabetic macular edema (DME) with central retinal thickness (CRT) < 400 μm. The results showed that SML therapy was equivalent to SL therapy and required slightly more laser treatments.
Article
Ophthalmology
Giselle Lynch, Adrienne W. Scott, Marguerite O. Linz, Ian Han, Jorge S. Romo, Rachel E. Linderman, Joseph Carroll, Richard B. Rosen, Toco Y. Chui
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Sally S. Ong, Marguerite O. Linz, Ximin Li, T. Y. Alvin Liu, Ian C. Han, Adrienne W. Scott
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Razek G. Coussa, Elaine M. Binkley, Mark E. Wilkinson, Jeaneen L. Andorf, Budd A. Tucker, Robert F. Mullins, Elliott H. Sohn, Lawrence A. Yannuzzi, Edwin M. Stone, Ian C. Han
Summary: Patients with AD-BVMD are predominantly hyperopic, whereas those with Stargardt disease are predominantly myopic. The findings provide further evidence of a role for BEST1 in ocular growth and development.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Cell Biology
Andrew E. Pouw, Mark A. Greiner, Razek G. Coussa, Chunhua Jiao, Ian C. Han, Jessica M. Skeie, John H. Fingert, Robert F. Mullins, Elliott H. Sohn
Summary: This review highlights the crucial role of the extracellular matrix (ECM) in maintaining normal physiologic functions and regulating processes such as angiogenesis and intraocular pressure in the eye. Various pathways and key factors related to ECM in the eye are discussed, along with alterations contributing to disease states like wound healing, diabetes-related complications, and age-related macular degeneration.
Article
Ophthalmology
Timothy M. Boyce, S. Scott Whitmore, Katayoun Varzavand, Stephen R. Russell, Elliott H. Sohn, James C. Folk, Edwin M. Stone, Ian C. Han
Summary: Patients with ADNIV have a high lifetime risk of severe vision loss, with tractional retinal detachment being an important risk factor for poor vision.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Endocrinology & Metabolism
Jonathan F. Russell, Ian C. Han
Summary: Recent studies have shown the utility of wide field swept-source OCTA for detecting all relevant features of diabetic retinopathy. An updated staging system leveraging the advantages of WF SS-OCTA has been proposed, allowing for detailed correlation of vascular and structural pathology over time. The technology has great potential for evaluating DR patients, and a new WF SS-OCTA-based staging system may be beneficial in both clinical practice and trials.
CURRENT DIABETES REPORTS
(2021)
Article
Ophthalmology
Rion J. Wendland, Chunhua Jiao, Stephen R. Russell, Ian C. Han, Luke A. Wiley, Budd A. Tucker, Elliott H. Sohn, Kristan S. Worthington
Summary: The study investigated the effects of scaffold modulus on surgical handling using photocrosslinked poly(ethylene glycol) dimethacrylate as a model polymer. It found that scaffolds with shear modulus above 35 kPa performed satisfactorily in handling, while those below this limit were too fragile for reliable transplantation. Moreover, there was increased variability in surgical handling performance in samples with shear moduli above 800 kPa.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Razek G. Coussa, Christopher R. Fortenbach, D. Brice Critser, Malia M. Collins, Budd A. Tucker, Robert F. Mullins, Elliott H. Sohn, Edwin M. Stone, Ian C. Han
Summary: The study found that the presence of subretinal pillar, focal choroidal excavation, or atrophy in patients with best vitelliform macular dystrophy is associated with poor BCVA, while eyes with Gass lesion type 1 have good BCVA, and those with type 5 have poor BCVA. OCT can identify these structural features, which are prognostically significant for BCVA.
BMJ OPEN OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Eli A. Perez, David A. Ramirez, Jared D. Peterson, Elaine M. Binkley, H. Culver Boldt, Karen M. Gehrs, Ian C. Han, Stephen R. Russell, Elliott H. Sohn, Scott A. Larson, Jonathan F. Russell
Summary: This study aimed to compare visual outcomes after open-globe injury (OGI) with those predicted by the Ocular Trauma Score (OTS), and to investigate the effect of treatment with pars plana vitrectomy (PPV). The study found that severe OGI had better visual outcomes than predicted by the OTS, and secondary PPV surgery significantly improved visual acuity despite poor prognostic predictions.
OPHTHALMOLOGY RETINA
(2023)
Editorial Material
Ophthalmology
Ian C. Han
OPHTHALMOLOGY RETINA
(2022)
Article
Ophthalmology
Ian C. Han, Razek Georges Coussa, Mahsaw Mansoor, D. Brice Critser, Elliott H. Sohn, Jonathan F. Russell, Edwin M. Stone
Summary: This study used OCT angiography to evaluate the prevalence of choroidal neovascularization (CNV) in Best vitelliform macular dystrophy (BVMD) and identify associated structural features. The presence of CNV in the early stages of BVMD suggests that it may accelerate the evolution of vitelliform lesions.
OPHTHALMOLOGY RETINA
(2023)
Article
Multidisciplinary Sciences
S. Scott Whitmore, Adam P. DeLuca, Jeaneen L. Andorf, Justine L. Cheng, Mahsaw Mansoor, Christopher R. Fortenbach, D. Brice Critser, Jonathan F. Russell, Edwin M. Stone, Ian C. Han
Summary: Many retinal diseases lead to the loss of light-sensing photoreceptor cells (rods and cones), and characterizing the degree and pattern of this loss can help understand the pathology and prognosis of these diseases. While current technology like adaptive optics can visualize individual photoreceptors, it has limitations and is not widely used. In contrast, optical coherence tomography (OCT) is commonly used for retinal structure visualization but cannot distinguish between rod and cone loss. This study presents a computational model that can estimate rod and cone loss using OCT data alone, providing a powerful tool for research and clinical care.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Elliott H. Sohn, Ian C. Han, Benjamin R. Roos, Benjamin Faga, Meagan A. Luse, Elaine M. Binkley, H. Culver Boldt, James C. Folk, Stephen R. Russell, Robert F. Mullins, John H. Fingert, Edwin M. Stone, Todd E. Scheetz
Summary: The study confirmed the association between the MMP9 locus and exudative AMD, indicating a potential role for extracellular matrix abnormalities in choroidal neovascularization.
OPHTHALMOLOGY SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Aaron Ricca, Ian C. Han, Jeremy Hoffman, Edwin M. Stone, Elliott H. Sohn
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Ophthalmology
Elliott H. Sohn, Razek Coussa, Ian C. Han, Chunhua Jiao, Jessica Thompson, Kristan Worthington, Robert F. Mullins, Edwin M. Stone, Budd Tucker, Stephen R. Russell
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)