Analysis of spatial osteochondral heterogeneity in advanced knee osteoarthritis exposes influence of joint alignment

Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells

(2019) Stephanie Morscheid et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Topographic modeling of early human osteoarthritis in sheep

(2019) Tamás Oláh et al.   Science Translational Medicine

Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis

(2019) Marc C. Hochberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Relationships between in vivo dynamic knee joint loading, static alignment and tibial subchondral bone microarchitecture in end-stage knee osteoarthritis

(2018) B.C. Roberts et al.   OSTEOARTHRITIS AND CARTILAGE

Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces

(2018) Tamás Oláh et al.   Scientific Reports

Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment

(2018) Jagadeesh Venkatesan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis

(2017) Yan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Subregional laminar cartilage MR spin–spin relaxation times (T2) in osteoarthritic knees with and without medial femorotibial cartilage loss – data from the Osteoarthritis Initiative (OAI)

(2017) W. Wirth et al.   OSTEOARTHRITIS AND CARTILAGE

Attenuation of subchondral bone abnormal changes in osteoarthritis by inhibition of SDF-1 signaling

(2017) Y. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Location-independent analysis of structural progression of osteoarthritis—Taking it all apart, and putting the puzzle back together makes the difference

(2017) Felix Eckstein et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Longitudinal Changes in Magnetic Resonance Imaging-Based Measures of Femorotibial Cartilage Thickness as a Function of Alignment and Obesity: Data From the Osteoarthritis Initiative

(2017) Rebecca Moyer et al.   ARTHRITIS CARE & RESEARCH

Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients

(2017) Yan Chen et al.   Bone Research

Histopathological assessment of primary osteoarthritic knees in large patient cohort reveal the possibility of several potential patterns of osteoarthritis initiation

(2017) V.P. Mantripragada et al.   Current Research in Translational Medicine

Systematic mapping of the subchondral bone 3D microarchitecture in the human tibial plateau: Variations with joint alignment

(2016) Bryant C. Roberts et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment: data from the Osteoarthritis Initiative

(2016) R. Moyer et al.   OSTEOARTHRITIS AND CARTILAGE

A novel algorithm for a precise analysis of subchondral bone alterations

(2016) Liang Gao et al.   Scientific Reports

What Are the Prognostic Factors for Radiographic Progression of Knee Osteoarthritis? A Meta-analysis

(2015) Alex N. Bastick et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Relationship Between Medial Meniscal Extrusion and Cartilage Loss in Specific Femorotibial Subregions: Data From the Osteoarthritis Initiative

(2015) K. Bloecker et al.   ARTHRITIS CARE & RESEARCH

Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part III: analysis of the microstructure of the subchondral bone and correlations with the articular cartilage and meniscus

(2014) Raphaela Ziegler et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis

(2014) P. Orth et al.   OSTEOARTHRITIS AND CARTILAGE

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

(2014) E. Thijssen et al.   RHEUMATOLOGY

Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

(2014) L. Stefan Lohmander et al.   Arthritis & Rheumatology

Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

(2013) Ashish Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Estimating the Burden of Total Knee Replacement in the United States

(2013) Alexander M Weinstein et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part II: standard and overcorrection do not cause articular cartilage degeneration

(2013) Raphaela Ziegler et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Reduction of Sample Size Requirements by Bilateral Versus Unilateral Research Designs in Animal Models for Cartilage Tissue Engineering

(2013) Patrick Orth et al.   TISSUE ENGINEERING PART C-METHODS

Genome-wide expression profiles of subchondral bone in osteoarthritis

(2013) Ching-Heng Chou et al.   ARTHRITIS RESEARCH & THERAPY

Effect of Subchondral Drilling on the Microarchitecture of Subchondral Bone

(2012) Patrick Orth et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study

(2012) Leena Sharma et al.   ANNALS OF THE RHEUMATIC DISEASES

Meniscus pathology, osteoarthritis and the treatment controversy

(2012) Martin Englund et al.   Nature Reviews Rheumatology

Temporal and spatial migration pattern of the subchondral bone plate in a rabbit osteochondral defect model

(2012) P. Orth et al.   OSTEOARTHRITIS AND CARTILAGE

Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans

(2012) Barton L. Wise et al.   ARTHRITIS CARE & RESEARCH

Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study

(2011) F. Intema et al.   ANNALS OF THE RHEUMATIC DISEASES

Varus-valgus alignment: Reduced risk of subsequent cartilage loss in the less loaded compartment

(2011) Kirsten Moisio et al.   ARTHRITIS AND RHEUMATISM

Definition and classification of early osteoarthritis of the knee

(2011) Frank P. Luyten et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Body mass index and alignment and their interaction as risk factors for progression of knees with radiographic signs of osteoarthritis

(2011) E. Yusuf et al.   OSTEOARTHRITIS AND CARTILAGE

The Basic Science of Human Knee Menisci

(2011) Alice J. S. Fox et al.   Sports Health-A Multidisciplinary Approach

Varus and valgus alignment and incident and progressive knee osteoarthritis

(2010) L. Sharma et al.   ANNALS OF THE RHEUMATIC DISEASES

The direct examination of three-dimensional bone architecture in vitro by computed tomography

(2010) Lee A. Feldkamp et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Alignment, body mass and their interaction on dynamic knee joint load in patients with knee osteoarthritis

(2010) R.F. Moyer et al.   OSTEOARTHRITIS AND CARTILAGE

Patterns of femorotibial cartilage loss in knees with neutral, varus, and valgus alignment

(2008) Felix Eckstein et al.   ARTHRITIS AND RHEUMATISM

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: An in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

(2008) Marta Kot et al.   BIOCHEMICAL PHARMACOLOGY